Research progress of the relationship between COX-2 and bone formation

Abstract

Abstract: Cyclooxygenase-2 (COX-2) is the rate-limiting enzyme of arachidonic acid (AA) synthesizing prostaglandin E2 (PGE2). It has various effects on bone metabolism that stimulate both bone resorption and formation through regulation of PGE2. Meanwhile, COX-2 can work by the participation of multiple signal transduction pathways in bone formation, including Gαs signaling pathway, mitogen-activated protein kinases (MAPKs) pathway and receptor activator of nuclear factor κB ligand (RANKL) signaling pathway. COX-2 was induced by many factors, and can be inhibited by the inhibitors such as non-steroidal anti-inflammatory drugs (NSAIDs). These factors can regulate the production of COX-2 and consequently have impact on bone tissue. The main PURPOSE of the article was to introduce the relationship between COX-2 and bone formation and its potential clinical applications.

Key words: Cyclooxygenase-2, Prostaglandin, Bone formation, Osteoblast, Osteoclast

CLC Number:

Q257

MA Wu-di, XIA Lun-guo, ZHOU Yu-ning, XU Yuan-jin. Research progress of the relationship between COX-2 and bone formation[J]. China Journal of Oral and Maxillofacial Surgery, 2016, 14(1): 83-88.

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