The biological effect of orthodontic tooth moving into alveolar cleft bone grafting area

Abstract

Abstract: PURPOSE: To study the biological effects of orthodontic tooth movement into alveolar cleft bone graft area, and evaluate expression of Trap/Rankl/Runx2 by real-time PCR. METHODS: The model of orthodontic tooth movement into alveolar cleft bone graft area was established in 8-week-old SD rats. The animals were sacrificed before orthodontic treatment and 1, 3, 5 days after orthodontic treatment. Bone formation was evaluated by H-E staining and the expression of Trap/Rankl/Runx2 was detected by Real-time PCR. SPSS 13.0 software package was used for two sample paired t test. RESULTS: The expression of Trap increased at early and middle stage, Rankl increased at early stage and Runx2 increased at late stage. CONCLUSIONS: Orthodontic tooth movement into alveolar cleft bone graft area promoted bone remodeling of embedded bone, induced osteoclastic process and subsequent osteogenesis.

Key words: Orthodontic tooth, Alveolar cleft, Bone graft area, Real-time PCR, Bone remodel

CLC Number:

R783.5

SUN Jian, CHEN Zhen-qi. The biological effect of orthodontic tooth moving into alveolar cleft bone grafting area[J]. China Journal of Oral and Maxillofacial Surgery, 2014, 12(2): 120-124.

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