Abstract: PURPOSE: To evaluate the effect of celecoxib in acute pain relief after extraction of impacted tooth. METHODS: In the randomized, double-blind placebo-controlled trial, 90 patients who underwent extraction of impacted mandibular third molar, were divided into 3 groups based on the use of ccelecoxib, ibuprofen and placebo. Each group had 30 patients. After 4 hours of extraction, patients were given 400 mg celecoxib in the celecoxib group, 400 mg ibuprofen in the ibuprofen group. While in the placebo group, 100 mg vitamin C was administrated. Pain and adverse events were recorded after extraction and application of 3 drugs. Chi-square test and analysis of variance were carried out for comparison between the three groups using SPSS 13.0 software package. RESULTS: There were significant differences in analgesic onset time, PID, PAR, SPID, TOPPAR and overall assessment between celecoxib group, ibuprofen and placebo group (P<0.05). Compared with celecoxib group and ibuprofen group, the analgesic effect was quite the same. 12 h after administration, only the PID of the two groups had significant difference (P<0.05). Within 24 h, there was no significant difference in time to onset of analgesia, PAR, SPID, TOPPAR, and overall assessment (P>0.05). CONCLUSIONS: Celecoxib has distinct analgesic effect in extraction of impacted teeth with acute severe pain.

Key words: Celecoxib, Impacted tooth, Extraction, Analgesia