Abstract: PURPOSE: To compare the changes of blood pressure and heart rate in patients with hypertension who took different oral medications to control hypertension before tooth extraction and to find a way to better control hypertension around tooth extraction. METHODS: Ninety patients with hypertension undergoing controlled hypotension medication were given three different drugs randomly, including diazepam, nifedipine and diazepam combined with nifedipine. Blood pressure and heart rate during extraction were recorded in detail. The data was analyzed with SPSS17.0 software package for either t test or Chi-square test. RESULTS: Changes of perioperative blood pressure and heart rate was relatively stable after controlled hypotension medication. Difficulty and time during tooth extraction were charged slightly in both diazepam group and diazepam combined with nifedipine group, but significantly in nifedipine group. There was no significant change in heart rate in all groups. CONCLUSION: Controlled hypotension by oral medication before extraction could lower the blood pressure well. Combined medications can better ensure the safety of patients with hypertension during tooth extraction.

Key words: Hypertension, Extraction, Controlled hypotension