The effect of preemptive analgesia on postoperative pain relief and MDAS score after minimally invasive extraction of impacted teeth

doi:10.19438/j.cjoms.2024.01.008

Abstract

Abstract: PURPOSE: To investigate the effect of preemptive analgesia on postoperative pain relief after minimally invasive extraction of impacted teeth and the modified Dental Anxiety Scale (MDAS) score. METHODS: A total of 100 patients with impacted teeth admitted to Rudong Hospital of Traditional Chinese Medicine in Nantong City from July 2021 to May 2022 were selected and randomly divided into the experimental group(minimally invasive tooth extraction combined with preemptive pain relief treatment, n=50) and control group (minimally invasive tooth extraction, n=50) using a random number table method. The operation time, intraoperative blood pressure and heart rate, analgesic efficacy, postoperative visual analogue scale (VAS score) of pain, postoperative MDAS score and adverse reactions were compared between the two groups, and the data were statistically analyzed by SPSS 22.0 software package. RESULTS: The operation time of the experimental group was significantly less than that of the control group(P<0.05). VAS scores at 5 h, 10 h and 24 h in the experimental group were significantly lower than those in the control group(P<0.05). The MDAS score after treatment was lower than before treatment, and the experimental group was significantly lower than the control group(P<0.05). The incidence of adverse reactions after treatment was lower in both groups, and there was no significant difference between the two groups (P>0.05). CONCLUSIONS: Preemptive analgesia has a good analgesic effect on minimally invasive extraction of impacted teeth, which can improve the anxiety of patients, and has fewer adverse reactions. It can be widely used in clinical practice.

Key words: Preemptive analgesia, Minimally invasive tooth extraction, Lidocaine, Loxoprofen Tablets, MDAS score

CLC Number:

R782.1

ZHU Cheng-zhang, WAN Hong-kun. The effect of preemptive analgesia on postoperative pain relief and MDAS score after minimally invasive extraction of impacted teeth[J]. China Journal of Oral and Maxillofacial Surgery, 2024, 22(1): 49-52.

References

[1] Alberto PL.Surgical exposure of impacted teeth[J]. Oral Maxillofac Surg Clin North Am, 2020, 32(4): 561-570.
[2] Nogueira DGM, Leão JC, Sales PHDH, et al.Piezoelectric surgery is effective in reducing pain, swelling, and trismus after removal of impacted lower third molars: a meta-analysis[J]. J Oral Maxillofac Surg, 2023, 81(4): 483-498.
[3] Erdil A, Akbulut N, Altan A, et al.Comparison of the effect of therapeutic elastic bandage, submucosal dexamethasone, or dexketoprofen trometamol on inflammatory symptoms and quality of life following third molar surgery: a randomized clinical trial[J]. Clin Oral Investig, 2021, 25(4): 1849-1857.
[4] 朱昊臻, 孙宇. 盐酸纳布啡超前镇痛对老年口腔颌面部肿瘤手术患者的影响[J].中国口腔颌面外科杂志, 2019, 17(4): 316-318.
Zhu HZ, Sun Y.The effects of preemptive analgesia with nalbuphine on postoperative pain in elder patients undergoing surgery of oral and maxillofacial neoplasms[J]. China Journal of Oral and Maxillofacial Surgery, 2019, 17(4): 316-318.
[5] Yamada T, Sakemi H.Loxoprofen-induced bullous fixed drug eruption[J]. J Gen Fam Med, 2019, 21(2): 21-22.
[6] 张志愿. 口腔科学[M]. 9版. 北京: 人民卫生出版社, 2018.
Zhang ZY.Stomatology[M]. 9th Ed. Beijing: People’s Medical Publishing House, 2018.
[7] Larsen MK, Kofod T, Duch K, et al.Efficacy of methylprednisolone on pain, trismus and quality of life following surgical removal of mandibular third molars: a double-blind, split-mouth, randomised controlled trial[J]. Med Oral Patol Oral Cir Bucal, 2021, 26(2): e156-e163.
[8] 常忠福,姜丹丹,张世坤,等.138例牙科种植术前患者焦虑水平与STAI量表相关性分析[J].上海口腔医学, 2021, 30(6): 663-666.
Chang ZF, Jiang DD, Zhang SK, et al.Correlation analysis between anxiety level of patients before dental implantation and STAI scale in 138 consecutive patients[J].Shanghai Journal of Stomatology, 2021, 30(6): 663-666.
[9] Sarica I, Derindag G, Kurtuldu E, et al.A retrospective study: do all impacted teeth cause pathology[J]. Niger J Clin Pract, 2019, 22(4): 527-533.
[10] Synan W, Stein K.Management of impacted third molars[J]. Oral Maxillofac Surg Clin North Am, 2020,32(4): 519-559.
[11] Yuriditsky E, Mitchell OJL, Moore WH, et al.Reduced CT iodine perfusion score is associated with adverse clinical outcomes in acute pulmonary embolism[J]. Vasc Med, 2023, 28(1): 59-61.
[12] Candotto V, Oberti L, Gabrione F, et al.Complication in third molar extractions[J]. J Biol Regul Homeost Agents, 2019, 33(Suppl 1): 169-172.
[13] Shrestha R, Paudel S, Cho P, et al.Identification of sulfonyl-loxoprofen as novel phase 2 conjugate in rat[J]. Biopharm Drug Dispos, 2019, 40(7): 234-241.
[14] Ji C, Yu Y, Zhang M, et al.Loxoprofen sodium alleviates oxidative stress and apoptosis induced by angiotensin Ⅱ in human umbilical vein endothelial cells (HUVECs)[J]. Drug Des Devel Ther, 2020, 14(8): 5087-5096.
[15] Kim Y, Seo C, Oh S, et al.Retraction note to: analysis of loxoprofen in tablets, patches, and equine urine as tert-butyldimethylsilyl derivative by gas chromatography-mass spectrometry[J]. Arch Pharm Res, 2019, 42(2): 191-196.
[16] Alqarni M, Namazi NI, Alshehri S, et al.Solubility optimization of loxoprofen as a nonsteroidal anti-inflammatory drug: statistical modeling and optimization[J]. Molecules, 2022, 27(14): 4357-4370.
[17] Asano T, Hattori T, Tanaka KI, et al.Antinociception by fluoro-loxoprofen, a novel non-steroidal anti-inflammatory drug with less ulcerogenic effects, in rat models of inflammatory pain[J]. Eur J Pharmacol, 2019, 844: 253-258.
[18] Pankey AN, Chandar A, Isaacson G.Safety of ibuprofen in children with G6PD deficiency: a systematic review[J]. Laryngoscope, 2022,132(6):1300-1305.