China Journal of Oral and Maxillofacial Surgery ›› 2023, Vol. 21 ›› Issue (5): 472-478.doi: 10.19438/j.cjoms.2023.05.008

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Clinical and radiographic analysis of 20 patients of congenital infiltrating lipomatosis of the face

XU Gui-song1, YANG Gong-xin2, YOU Yuan-he1, TIAN Zhuo-wei1, XIAO Meng1, DU Zhong1, WANG Yan-an1   

  1. 1. Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai Center of Head and Neck Oncology Clinical and Translational Science. Shanghai 200011;
    2. Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China
  • Received:2023-04-12 Revised:2023-05-12 Online:2023-09-20 Published:2023-10-11

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Abstract: PURPOSE: To summarize and analyze the clinical and radiographic characteristics of congenital infiltrating lipomatosis of the face (CILF). METHODS: Clinical and radiographic data of patients diagnosed with CILF were collected and retrospectively analyzed. Statistical analysis of characteristic radiographic changes was performed using GraphPad Prism 5.0 software package. RESULTS: Twenty patients diagnosed with CILF were included in the study(male to female ratio was 1:1). All suffered from hemifacial hypertrophy since birth, and showed features of hemifacial fatty infiltration thickening(cheek, temporal region, palatal mucosa, masseter space, etc.), deformity of maxillary tuberosity, abnormal mandibular density, etc. Compared with the healthy side, there were significant differences in soft tissue thickening and bone density(P<0.05). According to the distribution pattern of the trigeminal nerve, the frontal branch-related region was rarely affected, while the superior (80%-100%) and mandibular(25%-100%) branches had strong potential correspondence with CILF. CONCLUSIONS: CILFs have unique clinical and imaging features which are of great significance for early diagnosis and follow-up. Furthermore, CILFs are closely related to the controlled area of the superior and mandibular branches of the trigeminal nerve, suggesting that CILF may be related to early neural development.

Key words: Congenital infiltrating lipomatosis of the face, Radiographic characteristic, Trigeminal nerve

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