An experimental study of pathogenesis similarity between traumatic temporomandibular joint ankylosis and heterotopic ossification

doi:10.19438/j.cjoms.2023.05.006

Abstract

Abstract: PURPOSE: To investigate whether the pathogenesis of heterotopic ossification(HO) was similar to traumatic temporomandibular joint ankylosis(TMJA), and to provide new ideas for the prevention and treatment of TMJA. METHODS: Thirty cases of elbow, hip and knee joint HO and 30 cases of traumatic TMJA were selected. The bone samples of joint area and surrounding area were collected and preserved as experimental group A (group A) and experimental group B (group B) respectively. Five normal and complete coracoids were collected as the control group(group C). Structural forms of bone specimens were detected by H-E staining and expressions of BMP-2, BMP-4, CD34⁺ in the three groups were detected by immunohistochemical assay. Imaging data were used to compare the imaging features of group A and group B. SPSS 17.0 software package was used for data analysis. RESULTS: The histological structure and imaging features of group A and group B were basically the same. Immunohistochemistry showed that the positive expressions of BMP-2, BMP-4 and CD34⁺ in group A and group B were significantly stronger than those in group C (P<0.05). CONCLUSIONS: Traumatic TMJA and HO have similar pathogenesis.

Key words: Heterotopic ossification, Traumatic temporomandibular joint ankylosis, Pathogenesis

CLC Number:

R782.6

CHEN Yun-liang, MAN Cheng, LI Xiao-yu, WU Jing, WEI Liu-qiong, LI Wen-long. An experimental study of pathogenesis similarity between traumatic temporomandibular joint ankylosis and heterotopic ossification[J]. China Journal of Oral and Maxillofacial Surgery, 2023, 21(5): 461-466.

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