China Journal of Oral and Maxillofacial Surgery ›› 2022, Vol. 20 ›› Issue (3): 239-243.doi: 10.19438/j.cjoms.2022.03.006

• Original Articles • Previous Articles     Next Articles

Prognostic factors of primary intraosseous squamous cell carcinoma: a retrospective review of98consecutive cases

YANG Jin-gang1,2, XIA Rong-hui3, ZHU Yun1, WU Si-cheng4, DONG Ya-bing5, YANG Gong-xin6, SHI Jun-long1, CUI Ying-hui7, ZHU Ling6, ZHOU Shang-hui1   

  1. 1. Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology. Shanghai 200011;
    2. Department of Stomatology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200336;
    3. Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;
    4. Biostatistics Office of Clinical Research Unit, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;
    5. Department of Oral Surgery,Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China;
    6. Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China; 7. Department of Medical Affairs, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China
  • Received:2021-10-08 Revised:2022-01-17 Online:2022-05-20 Published:2022-05-20

PDF (PC)

164

Abstract: PURPOSE: To delineate the clinical and pathological features and determine the prognostic factors of primary intraosseous squamous cell carcinoma (PIOSCC). METHODS: The clinical, radiological, histopathological and postoperative follow-up data of patients diagnosed with PIOSCC in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from 2013 to 2017 were collected, and the prognostic factors of PIOSCC were analyzed by descriptive statistical methods. Baseline data were analyzed by univariate and multivariate survival analysis with SPSS 23.0 software package. RESULTS: A total of 98 patients with PIOSCC were enrolled, with a mean age of 56.6 years. Among them, there were 71 males and 27 females, and 33 in the maxilla, 65 in the mandible. Of the 95 patients followed up, 24 patients developed local recurrences and 10 patients developed distant metastases; furthermore, most local recurrences and distant metastasis occurred within 2 years after operation. The estimated 2-year and 5-year overall survival were 74.7% and 61.8%, respectively. Univariate analysis showed that tumor site, tumor size, positive margin, and cervical lymph node metastasis were significant prognostic factors for overall survival; facial numbness, positive margin were significant prognostic factors for local recurrences; and tumor site, cervical lymph node metastasis were significant prognostic factors for distant metastasis. Multivariate analysis showed that only positive margin and cervical lymph node metastasis remained as significant prognostic factors for overall survival. CONCLUSIONS: Recurrence, metastasis, and death occurred most frequently within 2 years after operation of PIOSCC. Positive margin and cervical lymph node metastasis were negative prognostic factors for PIOSCC.

Key words: Primary intraosseous squamous cell carcinoma, Prognostic factors, Clinicopathologic description

CLC Number: