Effects of intranasal midazolam spray as premedication on epileptiform EEG in children during induction with sevoflurane

doi:10.19438/j.cjoms.2020.03.010

Abstract

Abstract: PURPOSE: This clinical trial was performed to evaluate the effects of intranasal midazolam spray as premedication on the incidence of epileptiform EEG activity during induction with sevoflurane in children. METHODS: Eighty-six patients(0.5-6 years, ASA Ⅰ-Ⅱ) undergoing elective oral and maxillofacial surgery under general anesthesia were randomly allocated to two different premedication groups: midazolam group and normal saline group. After intranasal premedication spray in the waiting area, the patients were transferred to the operating room. The patients were anesthetized with 8% sevoflurane via face mask. EEGs during induction were continuously recorded and analyzed. Statistical analysis was performed using SPSS 25 software package. RESULTS: Twenty-three patients (53%, DSP30%, PSR37%, PED9%) in midazolam group had epileptiform EEG patterns compared to 29 patients (67%, DSP37%, PSR35%, PED19%) in normal saline group (P=0.186). The time from start of sevoflurane until loss of consciousness was shorter in midazolam group than in normal saline group, but the difference was not significant [(41.6±11.0)s vs (44.1±16.1)s,P=0.409]. CONCLUSIONS: 0.4 mg/kg midazolam intranasal spray before operation can not reduce the occurrence of epileptiform EEG in children during sevoflurane induction.

Key words: Midazolam, Sevoflurane, Epileptiform EEG

CLC Number:

R782.05

SUO Lu-lu, BAO Yong-yang, SUN Yu. Effects of intranasal midazolam spray as premedication on epileptiform EEG in children during induction with sevoflurane[J]. China Journal of Oral and Maxillofacial Surgery, 2020, 18(3): 240-244.

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