CDH1 gene methylation and E-cadherin in salivary malignant pleomorphic adenoma

doi:10.19438/j.cjoms.2018.02.005

Abstract

Abstract: PURPOSE: To analyze the correlation between CDH1 promoter methylation and E-cadherin expression in MPA, evaluate the role of CDH1 promoter methylation in E-cadherin silencing, explore the correlation between CDH1 methylation and clinicopathological parameters of MPA, and assess its potential prognostic value. METHODS: Immunohistochemistry and BSP were used to detect the expression of E-cadherin and the degree of CDH1 promoter methylation in MPA samples, and correlation analysis was performed. The data of patients were collected and followed up, and the correlation between CDH1 methylation and clinical pathological parameters and survival rate was analyzed. SPSS16.0 software package was used for statistical analysis. RESULTS: CDH1 hypermethylation was positively correlated with E-cadherin silencing expression. The degree of CDH1 methylation was significantly correlated with gender, tumor differentiation, histological grade, lymph node metastasis and TNM staging. The survival rate of patients with CDH1 hypermethylation was poor. Lymph node metastasis was an independent predictor of prognosis in patients with MPA. CONCLUSIONS: CDH1 gene hypermethylation is one of the important regulatory mechanisms of E-cadherin silencing in MPA. CDH1 methylation may be one of the predictors for clinical prognosis in patients with MPA.

Key words: E-cadherin, DNA methylation, Malignant pleomorphic adenoma

CLC Number:

R739.8

XIA Liang, HU Yu-hua, WANG li-zhen, GU Ting, LI Jiang, TIAN Zhen. CDH1 gene methylation and E-cadherin in salivary malignant pleomorphic adenoma[J]. China Journal of Oral and Maxillofacial Surgery, 2018, 16(2): 120-125.

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