China Journal of Oral and Maxillofacial Surgery ›› 2017, Vol. 15 ›› Issue (5): 385-387.doi: 10.19438/j.cjoms.2017.05.001

• Original Articles •     Next Articles

Spatiotemporal expression pattern of Fibulin-7 in the development process of murine mandibular first molars

OUYANG Ning-juan, LI Hong-liang, LIN Yu-heng, LU Chen-pei, DAI Jie-wen, SHEN Guo-fang.   

  1. Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine;
    Shanghai Key Laboratory of Stomatology. Shanghai 200011, China
  • Received:2016-11-15 Online:2017-08-30 Published:2017-10-27

Abstract: PURPOSE: To investigate the expression patterns of Fibulin-7 in murine tooth germs of mandibular first molars at early developmental stages. METHODS: Mandible samples of C57BL/6J mice of embryonic day 15.5, postnatal day 1 and day 7 were collected. The expressions of Fibulin-7 in murine mandibular first molar germs were detected by immunohistochemistry staining. RESULTS: The expression of Fibulin-7 was detected and gradually increased from late bell stage till maturation of tooth germs in mandibular first molars. CONCLUSIONS: Fibulin-7 was expressed at different stages through the development of tooth germs, indicating their individual functions in the process of mesenchymal cells into odontoblasts and the formation of pulp-dentin complex.

Key words: Fibulin-7, Mouse, Mandibular first molars, Spatiotemporal expression patterns

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