热灌注化疗对口腔颌面部恶性肿瘤患者NO及T淋巴细胞的影响

doi:10.19438/j.cjoms.2020.06.010

中国口腔颌面外科杂志 ›› 2020, Vol. 18 ›› Issue (6): 521-525.doi: 10.19438/j.cjoms.2020.06.010

热灌注化疗对口腔颌面部恶性肿瘤患者NO及T淋巴细胞的影响

刘英¹, 李晨曦², 王冰¹, 龚忠诚¹

1.新疆医科大学第一附属医院(附属口腔医院) 颌面肿瘤外科,新疆维吾尔自治区口腔医学研究所,新疆乌鲁木齐 830054;
2.汉堡大学艾本德附属医院头部及神经中心口腔颌面外科,口腔颌面部肿瘤遗传学及再生医学实验室,德国汉堡 20246

收稿日期:2020-02-11 修回日期:2020-05-24 出版日期:2020-11-20 发布日期:2020-12-31
通讯作者: 李晨曦E-mail:lichenximed@163.com;龚忠诚,E-mail:gump0904@aliyun.com。^*共同通信作者
作者简介:刘英(1984-),女,硕士研究生,主管护师,E-mail:50116625@qq.com

Effect of chemohyperthermia on nitric oxide and T lymphocyte in patients with oral and maxillofacial cancers

LIU Ying¹, LI Chen-xi², WANG Bing¹, GONG Zhong-cheng¹

1. Oncological Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinjiang Medical University, Stomatology School of Xinjiang Medical University, Stomatology Research Institute of Xinjiang Autonomous Region. Urumqi 830054, Xinjiang Autonomous Region, China;
2. Department of Oral and Maxillofacial Surgery, Laboratory for Tumor Genetics and Regenerative Medicine, The Head and Neurocenter, University Medical Center Hamburg-Eppendorf UKE. Hamburg 20246, Germany

Received:2020-02-11 Revised:2020-05-24 Online:2020-11-20 Published:2020-12-31

摘要/Abstract

摘要： 目的: 探讨热灌注化疗对口腔颌面部恶性肿瘤患者NO及T淋巴细胞的影响。方法: 选取汉堡大学休伯特斯·沃尔德癌症中心2017年12月—2019年12月收治的口腔颌面部恶性肿瘤患者60例,按照随机数字表法分为热化疗组(30例)与常规化疗组(30例),常规化疗组患者给予单纯静脉化疗,热化疗组患者在静脉化疗的基础上给予热化疗。比较2组患者的治疗效果、NO及T淋巴细胞数量、生存质量以及毒副反应之间的差异。采用SPSS 22.0软件包进行数据统计。结果: 热化疗组的治疗有效率及疾病控制率显著高于常规化疗组。治疗后,热化疗组患者NO含量显著高于常规化疗组,CD4⁺、CD4⁺/CD8⁺显著高于常规化疗组,热化疗组患者体力功能、情感功能、社会功能等功能性指标及综合生存质量评分显著高于常规化疗组,疲劳、疼痛、便秘等症状性指标显著低于常规化疗组,差异均具有统计学意义(P<0.05)。2组患者的毒副作用比较差异无统计学意义(P>0.05)。结论: 热化疗可显著提高口腔颌面部恶性肿瘤患者的治疗效果及NO含量,改善患者的免疫功能,提高生存质量,且安全性较高。

关键词: 热化疗, 一氧化氮, T淋巴细胞, 口腔颌面部恶性肿瘤, 免疫功能

Abstract: PURPOSE: To study the effects of chemohyperthermia on nitric oxide (NO) and T lymphocyte in patients with oral and maxillofacial cancers. METHODS: Sixty patients with oral and maxillofacial cancers admitted to University Cancer Center Hamburg (UCCH) from December 2017 to December 2019 were randomly divided into thermochemotherapy group(n=30) and conventional chemotherapy group(n=30) according to a random number table method. Patients in the conventional chemotherapy group were given intravenous chemotherapy alone, while patients in the thermochemotherapy group were given thermochemotherapy on the basis of intravenous chemotherapy. The therapeutic effect, NO, T lymphocyte, quality of life along with toxic and side effects of the two groups were compared. Statistical analysis of all data was performed using SPSS 22.0 software package. RESULTS: The effective rate of treatment and disease control rate in the thermochemotherapy group were significantly higher than those in the conventional chemotherapy group. After treatment, the content of NO in the conventional chemotherapy group was significantly lower than that in the thermochemotherapy group. CD4⁺,CD4⁺/CD8⁺ in the thermochemotherapy group were significantly higher than those in the conventional chemotherapy group. The functional indexes such as physical function, emotional function, social function and comprehensive quality of life scores in the thermochemotherapy group were significantly higher than those in the conventional chemotherapy group. The symptom indexes such as fatigue, pain and constipation in the thermochemotherapy group were significantly lower than those in the conventional chemotherapy group (P<0.05). There was no significant difference in toxic and side effects between the two groups (P>0.05). CONCLUSIONS: Chemohyperthermia can improve the therapeutic effect and NO content of patients with oral and maxillofacial cancer, improve the immune function of patients, enhance the quality of life of patients, and has higher safety.

Key words: Chemohyperthermia, Nitric oxide, T lymphocyte, Oral and maxillofacial cancer, Immunologic function

中图分类号:

R739.8

刘英, 李晨曦, 王冰, 龚忠诚. 热灌注化疗对口腔颌面部恶性肿瘤患者NO及T淋巴细胞的影响[J]. 中国口腔颌面外科杂志, 2020, 18(6): 521-525.

LIU Ying, LI Chen-xi, WANG Bing, GONG Zhong-cheng. Effect of chemohyperthermia on nitric oxide and T lymphocyte in patients with oral and maxillofacial cancers[J]. China J Oral Maxillofac Surg, 2020, 18(6): 521-525.

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热灌注化疗对口腔颌面部恶性肿瘤患者NO及T淋巴细胞的影响

Effect of chemohyperthermia on nitric oxide and T lymphocyte in patients with oral and maxillofacial cancers

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