引导组织再生膜促进兔下颌骨牵张成骨的实验研究

中国口腔颌面外科杂志 ›› 2014, Vol. 12 ›› Issue (6): 492-497.

引导组织再生膜促进兔下颌骨牵张成骨的实验研究

唐晓朋, 袁奎封, 来庆国, 杨中军, 慈江波

山东大学第二医院口腔科,山东济南 250033

收稿日期:2014-05-09 出版日期:2014-11-10 发布日期:2015-01-01
通讯作者: 袁奎封,Tel:0531-85875325,E-mail:ykf1963@126.com
基金资助:
山东省科技攻关项目(2011GGH21826)

Experimental study on the guided tissue regeneration membrane promoting bone formation in rabbit mandibular distraction osteogenesis

TANG Xiao-peng, YUAN Kui-feng, LAI Qing-guo, YANG Zhong-jun, CI Jiang-bo

Department of Stomatology, The Second Hospital of Shandong University. Jinan 250033, Shandong Province, China

Received:2014-05-09 Online:2014-11-10 Published:2015-01-01
Supported by:
Supported by Key Science and Technology Project of Shandong Province (2011GGH21826)

摘要/Abstract

摘要： 目的探讨引导组织再生膜（GTRM）对兔下颌骨牵张成骨新骨形成的促进作用。方法将20只新西兰大白兔随机分为2组,每组10只,建立兔下颌骨牵张成骨模型,A组单纯单侧下颌骨牵张成骨;B组将GTRM固定于牵张器内侧行单侧下颌骨牵张成骨。分别于固定期第2、6周时随机处死半数动物获取标本,通过X线、骨组织形态计量学比较2组牵张间隙内成骨效果。采用SPSS11.0软件包对数据进行两样本均数t检验。结果通过X线及骨组织形态计量学检查并经过统计学分析发现,在固定期第2周和6周时,B组牵张区域内成骨质量显著好于A组（P<0.05）。结论引导组织再生膜能有效促进兔下颌骨牵张成骨区域新骨的形成。

关键词: 引导组织再生膜, 牵张成骨, 下颌骨, 兔

Abstract: PURPOSE : To investigate the promotive effect of guided tissue regeneration membrane (GTRM) in rabbit mandibular distraction osteogenesis (DO). METHODS : Twenty New Zealand’s white rabbits were randomly divided into 2 groups with ten in each, and then mandibular distraction osteogenesis model in rabbits was established. In group A, only DO was performed on one side of the mandible; in group B, the distraction device was positioned and fixed on the mandible with GTRM inside wrapped around the distraction zone. Half of the animals randomly chosen from each group were sacrificed at the end of week 2 and 6 throughout the consolidation phase. The mandibular samples were taken out for X-ray and histologic examinations. The data was analyzed with SPSS 11.0 software package. RESULTS: Radiological and histological study confirmed that group B showed better bone formation than group A (P<0.05) at the end of 2nd and 6th week consolidation. CONCLUSION : GTRM could effectively promote bone regeneration in rabbit mandibular DO.

Key words: Guided tissue regeneration membrane, Distraction osteogenesis, Mandible, Rabbit

中图分类号:

R782.2

唐晓朋, 袁奎封, 来庆国, 杨中军, 慈江波. 引导组织再生膜促进兔下颌骨牵张成骨的实验研究[J]. 中国口腔颌面外科杂志, 2014, 12(6): 492-497.

TANG Xiao-peng, YUAN Kui-feng, LAI Qing-guo, YANG Zhong-jun, CI Jiang-bo. Experimental study on the guided tissue regeneration membrane promoting bone formation in rabbit mandibular distraction osteogenesis[J]. China J Oral Maxillofac Surg, 2014, 12(6): 492-497.

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