从循证医学角度探讨妊娠期头颈部癌症的治疗策略

doi:10.19438/j.cjoms.2024.02.002

中国口腔颌面外科杂志 ›› 2024, Vol. 22 ›› Issue (2): 118-127.doi: 10.19438/j.cjoms.2024.02.002

从循证医学角度探讨妊娠期头颈部癌症的治疗策略

李晨曦^1,2, 丁艺³, 刘慧⁴, 龚忠诚¹, 张维娜⁵, 赵化荣⁶

1.新疆医科大学第一附属医院（附属口腔医院）口腔颌面肿瘤外科,新疆维吾尔自治区口腔医学研究所,新疆乌鲁木齐 830054;
2.华中科技大学同济医学院附属协和医院口腔医学中心,口腔颌面发育与再生湖北省重点实验室,湖北武汉 430022;
3.汉堡大学附属艾本多夫医院妇产科,汉堡 20246 德国;
4.上海市口腔医院口腔颌面外科,上海市颅颌面发育与疾病重点实验室,上海 200031;
5.新疆医科大学第一附属医院耳鼻喉科,新疆乌鲁木齐 830054;
6.肿瘤中心一病区（头颈）,新疆乌鲁木齐 830054

收稿日期:2023-06-30 修回日期:2023-08-12 发布日期:2024-03-27
通讯作者: 龚忠诚,E-mail: gump0904@aliyun.com
作者简介:李晨曦（1989-）,男,博士,E-mail: lichenximed@163.com
基金资助:
国家自然科学基金（82360481）; 口腔颌面发育与再生湖北省重点实验室开放课题基金（2022kqhm008）; 新疆维吾尔自治区天山创新团队（2021D14001）; 新疆维吾尔自治区科研创新项目（XJ2023G174）

A perspective of evidence-based medicine on exploring the treatment strategy of head and neck cancer in pregnancy

LI Chen-xi^1,2, DING Yi³, LIU Hui⁴, GONG Zhong-cheng¹, ZHANG Wei-na⁵, ZHAO Hua-rong⁶

1. Department of Oral and Maxillofacial Oncology Surgery, the First Affiliated Hospital of Xinjiang Medical University, School & Hospital of Stomatology, Xinjiang Medical University; Stomatological Research Institute of Xinjiang Uygur Autonomous Region. Urumqi 830054, Xinjiang Uygur Autonomous Region;
2. Center of Stomatology, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology; Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration. Wuhan 430022, Hubei Province;
3. Department of Obstetrics and Gynecology, University Hospital Hamburg-Eppendorf(UKE). Hamburg 20246, Germany;
4. Department of Oral and Maxillofacial Surgery, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University. Shanghai 200031;
5. E.N.T. Department, , the First Affiliated Hospital of Xinjiang Medical University. Urumqi 830054, Xinjiang Uygur Autonomous Region, China;
6. The First Ward of Oncological Department, Cancer Center, the First Affiliated Hospital of Xinjiang Medical University. Urumqi 830054, Xinjiang Uygur Autonomous Region, China

Received:2023-06-30 Revised:2023-08-12 Published:2024-03-27

摘要/Abstract

摘要： 虽然妊娠期合并恶性肿瘤较为罕见,但随着女性妊娠期年龄的增大、头颈部癌症（head and neck cancer, HNC）患者的年轻化,妊娠期合并HNC的发病率略有增加。然而,目前临床尚缺乏关于妊娠期HNC的规范化诊疗标准。本研究通过系统检索PubMed数据库,评估孕妇（含围产期）患HNC的频率、肿瘤类型、相关因素和特异性生物标志物,并依据循证医学证据,对妊娠期合并HNC的研究进行综述,以期为临床工作提供指导。

关键词: 头颈部癌症, 孕妇, 回顾性分析, 免疫学, 分子生物学

Abstract: The occurrence of malignant tumor during pregnancy is relatively rare, but with the increased age of pregnant women and the decreased age of patients suffering from head and neck cancer(HNC), the incidence of HNC complicated with pregnancy is slightly increasing. However, at present, there has been a lack of standardized diagnosis and treatment standards for pregnant woman with HNC. This paper evaluated the frequency, tumor type, associated factors, and specific biomarkers in HNCs occurring in pregnant women (including peripartum), based on systematic literature retrieval that performed on PubMed databank. From an evidence-based medicine view, this review presents a comprehensive description of the studies of pregnancy complicated with HNC, and intends to provide guidance in clinical practice.

Key words: Head and neck cancer, Pregnant woman, Retrospective analysis, Immunology, Molecular biology

中图分类号:

R739.8

李晨曦, 丁艺, 刘慧, 龚忠诚, 张维娜, 赵化荣. 从循证医学角度探讨妊娠期头颈部癌症的治疗策略[J]. 中国口腔颌面外科杂志, 2024, 22(2): 118-127.

LI Chen-xi, DING Yi, LIU Hui, GONG Zhong-cheng, ZHANG Wei-na, ZHAO Hua-rong. A perspective of evidence-based medicine on exploring the treatment strategy of head and neck cancer in pregnancy[J]. China J Oral Maxillofac Surg, 2024, 22(2): 118-127.

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从循证医学角度探讨妊娠期头颈部癌症的治疗策略

A perspective of evidence-based medicine on exploring the treatment strategy of head and neck cancer in pregnancy

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