关键词: 口腔癌, 发病率, 死亡率, Joinpoint回归模型

Abstract: PURPOSE: To analyze the change trend of the incidence and mortality of oral and pharyngeal cancer according to Fujian Province Cancer Registry Annual Report from 2011 to 2017, and to provide scientific references for the prevention and treatment of oral and pharyngeal cancer. METHODS: The incidence and mortality of oral and pharyngeal cancer in Fujian province from 2011 to 2017 were collected and summarized, stratified by sex and age group (0-,5-,10-,……, 85-). Joinpoint regression model was applied to analyze the change trend of the incidence and mortality of oral and pharyngeal cancer in Fujian province. RESULTS: The trend of incidence and mortality of oral and pharyngeal cancer in Fujian province from 2011 to 2017 was not statistically significant(APC of incidence was -0.11%, P=0.958; APC of mortality was 0.59%,P=0.826).The incidence was higher in males than in females from 2011 to 2017. The incidence of oral and pharyngeal cancer in males before the age of 35 years old was at a low level and the trend was smooth. The incidence of oral and pharyngeal cancer in male aged 35-74 increased rapidly with age (P<0.001). The incidence decreased with age after 75 years old (P=0.01). The peak incidence was in the age group of 75-80 years. The incidence of oral and pharyngeal cancer in females before the age of 50 years old was at a low level and showed a slowly rising trend(P=0.06). The incidence of oral and pharyngeal cancer in female increased rapidly after 50 years old(P<0.001). The peak incidence was in the age group of 85- years. The mortality of oral and pharyngeal cancer in males before the age of 40 years old was at a low level and the trend was smooth. The mortality of oral and pharyngeal disease in male increased rapidly after 40 years old(P<0.001). The peak mortality was in the age group of 85- years. The trend curve of age-specific mortality in women was similar to that in men, with only one turning point, but the turning point moved backward in the age group of 55-60 years old. CONCLUSIONS: The incidence and mortality of oral and pharyngeal cancer in Fujian province from 2011 to 2017 were high, and the change was small. The incidence of oral and pharyngeal cancer in Fujian province is at a low level and tends to be flat before 35 years old in males and before 50 years old in females,since then it has improved. The mortality of oral and pharyngeal cancer in Fujian province is at a low level and tends to be flat before 40 years old in males and before 55 years old in females, since then it has improved. The preventive and therapeutic measures for oral and pharyngeal cancer should be formulated and improved actively.

Key words: Oral and pharyngeal cancer, Incidence, Mortality, Joinpoint regression analysis