穿刺活检在儿童及青少年颌面部肿瘤中的诊断价值

doi:10.19438/j.cjoms.2020.02.015

中国口腔颌面外科杂志 ›› 2020, Vol. 18 ›› Issue (2): 160-164.doi: 10.19438/j.cjoms.2020.02.015

穿刺活检在儿童及青少年颌面部肿瘤中的诊断价值

韩婧¹, 田臻², 张春叶², 刘剑楠¹

1.上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科;
2.口腔病理科,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海 200011

收稿日期:2019-10-21 修回日期:2019-12-25 出版日期:2020-03-20 发布日期:2020-04-30
通讯作者: 刘剑楠,E-mail: laurence_ljn@163.com
作者简介:韩婧（1985-）,女,博士,E-mail: hanjing0808@163.com
基金资助:
上海交通大学“转化医学交叉研究基金”（ZH2018QNA04）

Reliability and safety of puncture biopsy in the diagnosis of maxillofacial tumors in children and adolescents

HAN Jing¹, TIAN Zhen², ZHANG Chun-ye², LIU Jian-nan¹

1.Department of Oromaxillofacial Head and Neck Oncology;
2.Department of Oral Pathology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology. Shanghai 200011, China

Received:2019-10-21 Revised:2019-12-25 Online:2020-03-20 Published:2020-04-30

摘要/Abstract

摘要： 目的:探讨穿刺活检诊断儿童及青少年颌面部肿瘤的准确性和安全性。方法:收集2017年1月—2018年7月上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科门诊收治的18岁以下颌面部肿瘤病例共10例,其中男6例,女4例,平均年龄12岁（8~18岁）,所有患者均采用穿刺活检进行诊断。粗针穿刺：使用16G穿刺针取3~5条组织;细针穿刺：用10 mL针筒吸取细胞。对比穿刺病理及术后病理诊断,并记录穿刺后并发症情况。结果:粗针穿刺共4例,3例接受手术治疗。1例穿刺病理为纤维母细胞/肌纤维细胞性肿瘤。2例为横纹肌肉瘤,1例诊断为非肿瘤性病变。细针穿刺共6例,5例接受手术治疗。1例穿刺病理为朗格汉斯细胞组织细胞增生症或巨细胞肉芽肿待排;1例穿刺见大量血液;1例为小圆细胞肿瘤;1例为左下颌下淋巴结穿刺见大量炎症细胞;1例为上皮性恶性肿瘤;1例为横纹肌肉瘤。粗针及细针穿刺后进行手术的患者,大体标本病理诊断与穿刺病理诊断结果均一致。穿刺后均未发生大出血、伤口感染、肿瘤穿刺通道种植转移等并发症。结论:穿刺活检诊断儿童及青少年颌面部肿瘤安全、准确。

关键词: 粗针穿刺, 细针穿刺, 颌面部肿瘤, 儿童及青少年

Abstract: PURPOSE： To evaluate the accuracy and safety of puncture biopsy in the diagnosis of maxillofacial tumors in children and adolescents. METHODS: From January 2017 to July 2018, 10 cases of maxillofacial tumors under 18 years old were collected from the outpatient Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University, including 6 males and 4 females, with an average age of 12 years old (8-18 years old). In core needle biopsy, three to five pieces of tissues were taken with 16G needle. In fine needle aspiration, a 10 mL syringe was used to extract tissue. Puncture pathology and postoperative pathological diagnosis was compared. Complications were recorded. RESULTS: Core needle biopsy was performed in 4 cases and 3 cases received surgical treatment. One case was fibroblast/myofibroblast tumor. Two cases were rhabdomyosarcoma and one was diagnosed as non-neoplastic lesion. There were 6 cases of fine needle aspiration, and 5 cases received surgical treatment. One patient showed Langerhan's cell istiocytosis or giant cell granuloma. Large amount of blood was observed in 1 case. One case was small round cell tumor. One case showed a large number of inflammatory cells in the left submandibular lymph node. One case was epithelial malignant tumor. One case was rhabdomyosarcoma. The pathological diagnosis of resection specimens of the patients undergoing surgery after core needle biopsy and fine needle aspiration was consistent with the pathological diagnosis of puncture. No complications such as bleeding, wound infection, needle tract recurrence occurred after puncture. CONCLUSIONS: Core needle biopsy and fine needle aspiration are both safe and reliable in the diagnosis of suspected maxillofacial tumors in children and adolescents.

Key words: Core needle biopsy, Fine needle aspiration, Maxillofacial tumors, Children and adolescents

中图分类号:

R739.8

韩婧, 田臻, 张春叶, 刘剑楠. 穿刺活检在儿童及青少年颌面部肿瘤中的诊断价值[J]. 中国口腔颌面外科杂志, 2020, 18(2): 160-164.

HAN Jing, TIAN Zhen, ZHANG Chun-ye, LIU Jian-nan. Reliability and safety of puncture biopsy in the diagnosis of maxillofacial tumors in children and adolescents[J]. China J Oral Maxillofac Surg, 2020, 18(2): 160-164.

参考文献

[1] Hosokawa S, Takebayashi S, Sasaki Y, et al.Clinical analysis of false-negative fine needle aspiration cytology of head and neck cancers[J]. Postgrad Med, 2019, 131(2): 151-155.
[2] Chen R, Cai Q, Liang F, et al.Oral core-needle biopsy in the diagnosis of malignant parapharyngeal space tumors[J]. Am J Otolaryngol, 2019, 40(2): 233-235.
[3] Aregbesola SB, Ugboko VI, Akinwande JA, et al.Orofacial tumours in suburban Nigerian children and adolescents[J]. Br J Oral Maxillofac Surg, 2005, 43(3): 226-231.
[4] Ataide AP, Fonseca FP, Santos Silva AR, et al.Distribution of oral and maxillofacial lesions in pediatric patients from a Brazilian southeastern population[J]. Int J Pediatr Otorhinolaryngol, 2016, 90: 241-244.
[5] Das S, Das AK.A review of pediatric oral biopsies from a surgical pathology service in a dental school[J]. Pediatr Dent, 1993, 15(3): 208-211.
[6] Sato M, Tanaka N, Sato T, et al.Oral and maxillofacial tumours in children: a review[J]. Br J Oral Maxillofac Surg, 1997, 35(2): 92-95.
[7] Skinner RL, Davenport WD Jr, Weir JC, et al.A survey of biopsied oral lesions in pediatric dental patients[J]. Pediatr Dent, 1986, 8(3): 163-167.
[8] Ulmansky M, Lustmann J, Balkin N.Tumors and tumor-like lesions of the oral cavity and related structures in Israeli children[J]. Int J Oral Maxillofac Surg, 1999, 28(4): 291-294.
[9] Silas OA, Ige OO, Adoga AA, et al. Role of fine needle aspiration cytology (FNAC) as a diagnostic tool in paediatric head and neck lymphodenopathy [J]. J Otol Rhinol, 2015, 4(1): 10.4172/2324-8785.
[10] Lee DH, Baek HJ, Kook H, et al.Clinical value of fine needle aspiration cytology in pediatric cervical lymphadenopathy patients under 12-years-of-age[J]. Int J Pediatr Otorhinolaryngol, 2014, 78(1): 79-81.
[11] Howlett DC, Triantafyllou A.Evaluation: fine needle aspiration cytology, ultrasound-guided core biopsy and open biopsy techniques[J]. Adv Otorhinolaryngol, 2016, 78: 39-45.
[12] Howlett DC, Skelton E, Moody AB.Establishing an accurate diagnosis of a parotid lump: evaluation of the current biopsy methods - fine needle aspiration cytology, ultrasound-guided core biopsy, and intraoperative frozen section[J]. Br J Oral Maxillofac Surg, 2015, 53(7): 580-583.
[13] Metz T, Heider A, Vellody R, et al.Image-guided percutaneous core needle biopsy of soft-tissue masses in the pediatric population[J]. Pediatr Radiol, 2016, 46(8): 1173-1178.
[14] Avanzini S, Faticato MG, Sementa AR, et al.Video-assisted needle core biopsy in children affected by neuroblastoma: a novel combined technique[J]. Eur J Pediatr Surg, 2017, 27(2): 166-170.
[15] Yunker WK, Hassan SF, Ferrell LB, et al.Needle core biopsy in the diagnosis of pediatric thyroid neoplasms: a single institution retrospective review[J]. Pediatr Surg Int, 2013, 29(5): 437-443.
[16] Kawasaki T, Ishida M, Tada T, et al.Well-differentiated neuroendocrine tumor of the breast with recurrence due to needle tract seeding[J]. Virchows Arch, 2015, 466(4): 479-481.
[17] Giorgadze T, Qureshi F, Aulicino M, et al.Retroperitoneal recurrence of a stage 1 renal cell carcinoma four years following core biopsy and fine needle aspiration: possible needle tract seeding[J]. Diagn Cytopathol, 2013, 41(5): 470-472.

穿刺活检在儿童及青少年颌面部肿瘤中的诊断价值

Reliability and safety of puncture biopsy in the diagnosis of maxillofacial tumors in children and adolescents

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

编辑推荐

Metrics

本文评价