EGFR 单抗联合化疗治疗245例晚期头颈鳞癌疗效分析

doi:10.19438/j.cjoms.2019.02.006

中国口腔颌面外科杂志 ›› 2019, Vol. 17 ›› Issue (2): 129-133.doi: 10.19438/j.cjoms.2019.02.006

EGFR 单抗联合化疗治疗245例晚期头颈鳞癌疗效分析

王红¹, 吴云腾², 马旭辉², 郭伟^2,*, 任国欣^1,2,*

1.潍坊医学院口腔医学院,山东潍坊 261000;
2.上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科,上海 200011

收稿日期:2018-10-26 修回日期:2018-12-12 出版日期:2019-03-20 发布日期:2019-04-12
通讯作者: 郭伟,E-mail：guoweicn@yahoo.com;任国欣,E-mail：renguoxincn@sina.com。^*共同通信作者
作者简介:王红（1991-）,女,硕士研究生,E-mail：13853659313@163.com
基金资助:
上海市科学技术委员会科研资助项目（10410711200,08140902100,11495802000,14DZ1941400）

Efficacy of EGFR monoclonal antibody combined with chemotherapy in treatment of 245 patients with advanced head and neck squamous cell carcinoma

WANG Hong¹, WU Yun-teng², MA Xu-hui², GUO Wei², REN Guo-xin^1,2

1.School of Stomatology, Weifang Medical University.Weifang 261000, Shangdong Province;
2.Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China

Received:2018-10-26 Revised:2018-12-12 Online:2019-03-20 Published:2019-04-12

摘要/Abstract

摘要： 目的:评价表皮生长因子受体（EGFR）单抗（泰欣生）治疗晚期头颈部鳞癌的有效性和安全性。方法:选取上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科2008年5月—2017年12月收治的245例晚期（Ⅲ-Ⅳ期）头颈鳞癌患者作为研究对象,分为原发组与复发组,其中原发组152例,复发组93例。原发组和复发组治疗方案均为以铂类为主的化疗联合EGFR单抗100~200 mg/次静滴,分析2组患者的用药安全性和有效性。采用SPSS 17.0软件包对数据进行统计学分析。结果:治疗后,原发组42例口咽癌患者总有效率为81.0%,110例口腔癌患者总有效率为45.4%;复发组9例口咽癌患者总有效率为44.4%,84例口腔癌患者总有效率为27.4%。原发组中位生存期为57个月,复发组中位生存期为8个月;治疗5年后,原发组总生存率为47.7%,复发组总生存率为8.0%。皮疹为EGFR单抗主要不良反应,但发生率仅为1.63%。结论:EGFR单抗联合以铂类为主的化疗对晚期头颈部鳞癌比单纯化疗有更高的有效率和生存率,且止痛效果显著,为手术等后续治疗创造了更好的条件,并可有效改善患者的生活质量,未增加严重化疗不良反应,安全性良好,具有很高的临床推广应用价值。

关键词: EGFR单抗, 头颈部, 鳞癌, 晚期

Abstract: PURPOSE: To study the efficacy and safety of epidermal growth factor receptor(EGFR) monoclonal antibody in the treatment of advanced head and neck squamous cell carcinoma. METHODS: Two hundred and forty-five patients with advanced (stage III-IV) head and neck squamous cell carcinoma were selected from May 2008 to December 2017. They were divided into primary group (n=152) and relapse group (n=93). Both groups received platinum-based chemotherapy combined with EGFR monoclonal antibody 100-200 mg per intravenous drip. The safety and efficacy of the treatment were analyzed. SPSS 17.0 software package was used for statistical analysis. RESULTS: After treatment, the total effective rate was 81.0% in 42 patients with primary oropharyngeal cancer and 45.4% in 110 patients with primary oral cancer, 44.4% in 9 patients with recurrent oropharyngeal cancer and 27.4% in 84 patients with recurrent oral cancer. The median survival time was 57 months in the primary group and 8 months in the relapse group. After five years of treatment, the overall survival rate was 47.7% in the primary group and 8.0% in the relapse group. Skin rash was the main side effect of EGFR mAb, but the incidence was only 1.63%. CONCLUSIONS: EGFR monoclonal antibody combined with platinum-based chemotherapy for advanced head and neck squamous cell carcinoma has a higher effective rate and survival rate than chemotherapy alone, and the analgesic effect is remarkable, which creates a better treatment opportunity for subsequent treatment such as surgery, and can effectively improve the quality of life of patients, and does not increase serious adverse reactions of chemotherapy.

Key words: EGFR monoclonal antibody, Head and neck, Squamous cell carcinoma, Advanced stage

中图分类号:

R739.8

王红, 吴云腾, 马旭辉, 郭伟, 任国欣. EGFR 单抗联合化疗治疗245例晚期头颈鳞癌疗效分析[J]. 中国口腔颌面外科杂志, 2019, 17(2): 129-133.

WANG Hong, WU Yun-teng, MA Xu-hui, GUO Wei, REN Guo-xin. Efficacy of EGFR monoclonal antibody combined with chemotherapy in treatment of 245 patients with advanced head and neck squamous cell carcinoma[J]. China J Oral Maxillofac Surg, 2019, 17(2): 129-133.

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EGFR 单抗联合化疗治疗245例晚期头颈鳞癌疗效分析

Efficacy of EGFR monoclonal antibody combined with chemotherapy in treatment of 245 patients with advanced head and neck squamous cell carcinoma

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