术前全身合并症情况及营养状态对老年口腔鳞癌患者预后的影响

doi:10.19438/j.cjoms.2017.03.009

中国口腔颌面外科杂志 ›› 2017, Vol. 15 ›› Issue (3): 235-239.doi: 10.19438/j.cjoms.2017.03.009

术前全身合并症情况及营养状态对老年口腔鳞癌患者预后的影响

刘喆麒，曹巍，任振虎，彭灿邦，季彤*，王悦平*

上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科，上海市口腔医学重点实验室，上海 200011

收稿日期:2016-08-22 修回日期:2016-11-28 出版日期:2017-05-20 发布日期:2017-06-09
通讯作者: 国家自然科学基金（81672745，81671009）；上海高校高峰高原学科建设项目
作者简介:刘喆麒（1992-），男，硕士，住院医师，E-mail：734672500@qq.com
基金资助:
王悦平，E-mail：18121213995@163.com；季彤，E-mail：jitong70@hotmail.com。*共同通信作者

Influence of preoperative comorbidities and nutrition status on elderly patients with oral squamous cell carcinoma

LIU Zhe-qi, CAO Wei, REN Zhen-hu, PENG Can-bang, JI Tong, WANG Yue-ping.

Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology Shanghai Jiao Tong University School of Medicine；Shanghai Key Laboratory of Stomatology. Shanghai 200011, China

Received:2016-08-22 Revised:2016-11-28 Online:2017-05-20 Published:2017-06-09

摘要/Abstract

摘要： 目的：探讨老年口腔癌患者术前全身合并症情况及营养状态对预后的影响。方法：收集2010年1月—2012年12月间手术治疗的老年（年龄≥60岁）口腔鳞癌患者的相关病史资料，回顾分析合并症指数（Charlson、HNCA、ACT指数）以及营养指数（nutrition index, NI）对术后生存率的影响。采用SPSS 17.0软件包对数据进行统计学分析。结果：465例患者中，死亡170例，Charlson、HNCA以及ACT指数与患者预后（总生存率OS）无相关性（P=0.747、0.530、0.869），术前营养状态与预后相关，营养指数是老年口腔癌患者预后的独立危险因素（P<0.001），得分越高，预后越差。结论：对于老年口腔鳞癌患者，术前全身系统性疾病并不是影响预后的独立因素，术前营养状态越差，生存率越低。

关键词: 老年人, 口腔鳞癌, 营养状态, 预后

Abstract: PURPOSE: To evaluate the influence of pre-operative comorbidities and nutrition status on elderly patients with oral squamous cell carcinoma (OSCC). METHODS: The data of elderly patients with OSCC treated between January 2010 to December 2012 in the Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine was analyzed. Patients who were histologically diagnosed as squamous cell carcinoma, aged over 60 years and surgically managed were included. The comorbidity index including Charlson, HNCA and ACT index and nutrition index (NI) were analyzed. RESULTS: Among 465 patients, preoperative Charlson, HNCA and ACT index didn't show significant impact on outcome of disease (P=0.747, 0.530, 0.869). Preoperative nutrition status and nutrition index were independent factors for prediction of prognosis (P<0.001). CONCLUSIONS: For elderly patients with OSCC, preoperative systemic disease is not a predictive factor for prognosis; however, the worse the preoperative nutritional status, the lower the survival rate.

Key words: Elderly patients, Oral squamous cell carcinoma, Nutrition status, Prognosis

中图分类号:

R739.8

刘喆麒，曹巍，任振虎，彭灿邦，季彤*，王悦平*. 术前全身合并症情况及营养状态对老年口腔鳞癌患者预后的影响[J]. 中国口腔颌面外科杂志, 2017, 15(3): 235-239.

LIU Zhe-qi, CAO Wei, REN Zhen-hu, PENG Can-bang, JI Tong, WANG Yue-ping.. Influence of preoperative comorbidities and nutrition status on elderly patients with oral squamous cell carcinoma[J]. China J Oral Maxillofac Surg, 2017, 15(3): 235-239.

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术前全身合并症情况及营养状态对老年口腔鳞癌患者预后的影响

Influence of preoperative comorbidities and nutrition status on elderly patients with oral squamous cell carcinoma

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