生物胶联合OK-432及博莱霉素治疗颌面部软组织动静脉畸形13例临床分析

doi:10.19438/j.cjoms.2017.01.016

中国口腔颌面外科杂志 ›› 2017, Vol. 15 ›› Issue (1): 73-76.doi: 10.19438/j.cjoms.2017.01.016

生物胶联合OK-432及博莱霉素治疗颌面部软组织动静脉畸形13例临床分析

秦泽曼, 黄志权, 陈伟良, 赵小朋, 陈睿

中山大学孙逸仙纪念医院口腔颌面外科,广东广州 510120

出版日期:2017-01-20 发布日期:2017-02-27
通讯作者: 陈伟良,E-mail：drchen@vip.163.com
作者简介:秦泽曼（1989-）,女,硕士,住院医师,E-mail：527969978@qq.com

Percutaneous sclerotherapy of arteriovenous malformations of the maxillofacial soft tissues using fibrin glue combined with OK-432 and bleomycin following embolization in 13 consecutive patients

QIN Ze-man, HUANG Zhi-quan, CHEN Wei-liang, ZHAO Xiao-peng, CHEN Rui

(Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital, Sun Yat-sen University. Guangzhou 510120, Guangdong Province, China)

Online:2017-01-20 Published:2017-02-27

摘要/Abstract

摘要： 目的评价生物胶联合OK-432及博莱霉素治疗颌面部软组织动静脉畸形（arteriovenous malformations,AVMs）的临床疗效。方法 13例颌面部软组织AVMs患者,男8例,女5例,平均年龄28.2岁。在超选择性血管内栓塞基础上,通过经皮注射生物胶联合OK-432及博莱霉素3~5次进行硬化治疗。结果除术区1周内肿胀外,均无严重并发症出现。随访14~58个月（平均27.4个月）,3例治愈,8例显效,2例有效,无无效病例。结论生物胶联合OK-432及博莱霉素经皮硬化治疗术治疗颌面部软组织AVMs效果良好,方法简单、安全、可靠。

关键词: 动静脉畸形, 生物胶, OK-432, 博莱霉素, 栓塞治疗

Abstract: PURPOSE: To evaluate the clinical curative effect of percutaneous sclerotherapy of arteriovenous malformations (AVMs) of soft tissues of the maxillofacial region using fibrin glue combined with OK-432 and bleomycin. METHODS: Thirteen patients with AVMs of the maxillofacial region (8 males and 5 females; mean age: 28.2 years, range: 16-46 years) were treated with a percutaneous injection of fibrin glue combined with OK-432 and bleomycin for 3-5 times following super-selective intra-arterial embolization (SIAE). RESULTS: All patients had significant swelling postoperatively for up to 1 week without major complications. The follow-up period ranged from 14-58 months (mean: 27.4 months). Three lesions were completely involuted, eight lesions were mostly involuted, and other two lesions were partially involuted. None of the lesions showed minimal involution or non-involution. CONCLUSIONS: Percutaneous sclerotherapy using fibrin glue combined with OK-432 and bleomycin following SIAE provides a simple, safe, and reliable alternative treatment for AVMs of soft tissues of maxillofacial region.

Key words: Arteriovenous malformation, Fibrin glue, OK-432, Bleomycin, Embolization, Maxillofacial region

中图分类号:

R782.2

秦泽曼, 黄志权, 陈伟良, 赵小朋, 陈睿. 生物胶联合OK-432及博莱霉素治疗颌面部软组织动静脉畸形13例临床分析[J]. 中国口腔颌面外科杂志, 2017, 15(1): 73-76.

QIN Ze-man, HUANG Zhi-quan, CHEN Wei-liang, ZHAO Xiao-peng, CHEN Rui. Percutaneous sclerotherapy of arteriovenous malformations of the maxillofacial soft tissues using fibrin glue combined with OK-432 and bleomycin following embolization in 13 consecutive patients[J]. China J Oral Maxillofac Surg, 2017, 15(1): 73-76.

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生物胶联合OK-432及博莱霉素治疗颌面部软组织动静脉畸形13例临床分析

Percutaneous sclerotherapy of arteriovenous malformations of the maxillofacial soft tissues using fibrin glue combined with OK-432 and bleomycin following embolization in 13 consecutive patients

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