Effect of mineral trioxide aggregate, autologous platelet-rich fibrin on alveolar bone regeneration in patients with maxillary anterior tooth extraction

doi:10.19438/j.cjoms.2022.03.010

Abstract

Abstract: PURPOSE: To investigate the effect of mineral trioxide aggregate (MTA) and autologous platelet-rich fibrin (PRF) on alveolar bone regeneration in patients with maxillary anterior tooth extraction. METHODS: Sixty-six patients receiving maxillary anterior tooth extraction in Hangzhou Stomatological Hospital from January 2017 to December 2019 were enrolled, and divided into 3 groups according to different filling materials: MTA group, PRF group and combined group, with 22 cases in each group. Cone-beam CT(CBCT) was performed before operation, 1, 3, 6 and 12 months after operation. Healing of injured tissue, alveolar bone density and alveolar bone volume were compared among 3 groups. The data were processed using SPSS 21.0 software package. RESULTS: A total of 61 patients completed the follow up(92.42%, 61/66), including 20 cases in MTA group, 20 cases in PRF group and 21 cases in combined group. Compared with the baseline data, MTA group, PRF group and combined group showed an increment in alveolar bone density 3, 6 and 12 months postoperatively (P<0.05). The alveolar bone density 6 and 12 months postoperatively in combined group were significantly higher than that in MTA group and PRF group(P<0.05), and the alveolar bone density 6 months and 12 months postoperatively in MTA group were significantly higher than that in PRF group. Alveolar bone volume showed a decrease in all 3 groups at postoperative 3, 6 and 12 months(P<0.05), alveolar bone volume of combined group at postoperative 6 and 12 months were significantly lower than that of PRF group(P<0.05). CONCLUSIONS: In single application, MTA has a better effect on restoration and regeneration of alveolar bone in patients with maxillary extraction than PRF, while combined application of the two has the best long-term effect in alveolar bone regeneration.

Key words: Mineral trioxide aggregate, Platelet-rich fibrin, Alveolar bone regeneration, Alveolar bone density, Alveolar bone volume

CLC Number:

R782.1

TANG Tian; , CHENG Qun; , DING Zi-qing; , ZHU Xin-ling; , HU Ying-ying;. Effect of mineral trioxide aggregate, autologous platelet-rich fibrin on alveolar bone regeneration in patients with maxillary anterior tooth extraction[J]. China Journal of Oral and Maxillofacial Surgery, 2022, 20(3): 263-267.

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