Expression and significance of pyruvate kinase M2 and CD276 in head and neck squamous cell carcinoma

doi:10.19438/j.cjoms.2020.04.002

China Journal of Oral and Maxillofacial Surgery ›› 2020, Vol. 18 ›› Issue (4): 297-301.doi: 10.19438/j.cjoms.2020.04.002

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Expression and significance of pyruvate kinase M2 and CD276 in head and neck squamous cell carcinoma

CHANG Han-yue^1,2, MA Hai-long², YANG Xi², ZHANG Zhi-yuan^1,2

1. Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University. Guangzhou 510140, Guangdong Province;
2. Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Disease; Shanghai Key Laboratory of Stomatology & Shanghai Reasearch Institute of Stomatology. Shanghai 200011, China

Received:2019-11-28 Online:2020-07-20 Published:2020-09-10

Abstract

Abstract: PURPOSE: To investigate the expression and correlation between pyruvate kinase M2 (PKM2) and B7H3 (CD276) in head and neck squamous cell carcinoma (HNSCC) patients. METHODS: Immunohistochemical staining was used to detect the expression of PKM2 and CD276 in 70 HNSCC tissues and 18 normal oral mucosa tissues. The relationship between the expression of PKM2 and CD276 in OSCC tissues and clinical pathological characteristics were analyzed using SPSS13.0 software package. RESULTS: The expression of PKM2 and CD276 in HNSCC was significantly higher than that in normal oral mucosa. The expression of PKM2 and CD276 was strongly associated with TNM stage (P<0.05), while no correlation with gender, age, pathological differentiation grade(P>0.05). The expression of CD276 was positively correlated with the expression of PKM2 in HNSCC. CONCLUSIONS: High expression of PKM2 and CD276 in HNSCC was closely related with malignant progression, and PKM2 may participate in immune regulation by promoting CD276 expression.

Key words: Pyruvate kinase M2, CD276, head and neck squamous cell carcinoma

CLC Number:

R739.8

CHANG Han-yue, MA Hai-long, YANG Xi, ZHANG Zhi-yuan. Expression and significance of pyruvate kinase M2 and CD276 in head and neck squamous cell carcinoma[J]. China Journal of Oral and Maxillofacial Surgery, 2020, 18(4): 297-301.

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Expression and significance of pyruvate kinase M2 and CD276 in head and neck squamous cell carcinoma

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