Abstract: PURPOSE: To investigate the timing of rapid transfusion of single large-dose platelet in children with Kasabach-Merritt syndrome (KMP) before surgery. METHODS: A retrospective analysis was performed on 66 children with KMP in our center from June 2011 to December 2019. The effects of rapid transfusion of single large-dose platelet at different time periods before surgery was determined. Among them, 30 children received platelet transfusion 12⁺-24 h before surgery and 36 children received platelet transfusion 6-12 h before surgery. All patients received transfusion of high-dose rapid platelet with 1/2-2/3 of the treatment volume, and the transfusion was completed within 2-3 h. The effect on platelet correction at 1 h before operation was compared between two groups. Statistical analysis was performed using SPSS 21.0 software package. RESULTS: The 1 h platelet count (PLTC) before operation in 6-12 h group was in the normal range, even higher than the normal range; 4 cases in 12⁺-24 h group had a 1 h PLTC lower than the normal range; the platelet and 4 coagulation indices at 1 h before operation was compared between the two groups, the difference in platelet count was statistically significant(P<0.05). The platelet count between the two groups after operation had no significant difference(P>0.05). During the whole platelet transfusion process, no complications occurred, and the difference in heart rate before and after transfusion was not statistically significant. CONCLUSIONS: Six to twelve hours before surgery is a safer and more effective period of rapid transfusion of single large-dose platelet in children with KMP.

Key words: Kasabach-Merritt syndrome, Thrombocytopenia, Blood transfusion period, Infants