Mammaglobin expression and ETV6 gene alteration in salivary non-mammary analogue secretory carcinomas

Abstract

Abstract: PURPOSE: To determine the diagnostic value of mammaglobin (MMG) expression and ETV6 gene rearrangement in salivary gland carcinomas in addition to mammary analogue secretory carcinomas (MASC). METHODS: Ninety-five cases of salivary non-MASC carcinomas including 20 acinic cell carcinomas (AciCC), 10 polymorphous low-grade adenocarcinomas (PLGA), 6 salivary ductal carcinomas (SDC), 9 cystadenocarcinomas (CAC), 6 low-grade cribriform cystadenocarcinomas (LGCCC), 14 mucoepidermoid carcinomas (MEC), 14 malignant pleomorphic adenomas (MPA), and 16 adenoid cystic carcinomas (ACC) were selected for MMG immunohistochemical staining, and fluorescence in situ hybridization (FISH) method was further performed in the cases characterized as MMG positive. RESULTS: 29/95 cases showed diffuse or focal staining for MMG and 17 cases demonstrated strong positivity, which included 4/6 SDC, 4/9 CAC, 4/6 LGCCC, 3/8 MPA (adenocarcinoma subtype), 1/10 PLGA and 1/4 high grade MEC. ETV6 gene rearrangement was not detected in any of the 29 MMG-positive cases. CONCLUSIONS: MMG expression was observed in some cases of salivary non-MASC carcinomas, and a higher proportion of strongly positive cases were detected in SDC, LGCCC and CAC, while none of them harbored ETV6 gene rearrangement, indicating that MMG may not serve as a promising diagnostic marker for MASC,and molecular study is needed to distinguish MASC from other salivary gland carcinomas.

Key words: Mammaglobin, Mammary analogue secretory carcinoma, Salivary gland carcinoma, ETV6 gene rearrangement

CLC Number:

R780.2

SUN Jing-jing, TIAN Zhen, WANG Li-zhen, ZHANG Chun-ye, ZHANG Ying, LI Jiang. Mammaglobin expression and ETV6 gene alteration in salivary non-mammary analogue secretory carcinomas[J]. China Journal of Oral and Maxillofacial Surgery, 2016, 14(3): 223-227.

References

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