The clinicopathological features of extra-orbital giant cell angiofibroma in oromaxillofacial head and neck region

China Journal of Oral and Maxillofacial Surgery ›› 2015, Vol. 13 ›› Issue (2): 161-166.

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The clinicopathological features of extra-orbital giant cell angiofibroma in oromaxillofacial head and neck region

JIANG Jian-lei¹, DAI Tian-guo², TIAN Zhuo-wei², WANG Li-zhen³, HE Yue²

1.Department of Stomatology, Fujian Longyan People's Hospital. Longyan 364000, Fujian Province;
2. Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology. Shanghai 200011, China;
3. Department of Oral Pathology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology. Shanghai 200011, China

Received:2014-04-04 Revised:2014-06-12 Online:2015-03-20 Published:2015-04-23
Supported by:
Supported by National Natural Science Foundation of China (81271112), Development Foundation of Shanghai Municipal Human Resources and Social Security Bureau (201312) and SMC Rising Star-A Scholar of Shanghai Jiao Tong University(201312)

Abstract

Abstract: PURPOSE: To analyze the clinical features, histopathologic features, differential diagnosis and treatment of extra-orbital giant cell angiofibroma(EO-GCA) in oromaxillofacial head and neck region. METHODS: Data on 12 cases of EO-GCA reported in PubMed database and 2 cases in our hospital were collected and analyzed. RESULTS: Fourteen patients (nine females, five males) were included, their ages ranged from 24 to 84 years with an average age of 43.5 years. Most cases presented a slow-growing and painless mass. The size of the tumor was related to the anatomic location. Microscopic examination revealed a patternless ovoid or short spindle tumor cell, richly vascularized, and floret-like multinucleated giant cells. Immunohistochemical staining revealed strong positivity for the mesenchymal markers, such as CD34 and vimentin. Clinical misdiagnosis was common and final diagnosis relies on pathology. Complete surgical resection of the tumor can lead to a better prognosis and little local recurrence. CONCLUSIONS: EO-GCA in oromaxillofacial head and neck region is a rare benign soft tissue tumor easily misdiagnosed. Accurate diagnosis depends on histopathological examination. Complete surgical resection of the tumor has a better prognosis.

Key words: Oromaxillofacial head and neck region, Extra-orbital giant cell angiofibroma, Clinicopathological features

CLC Number:

R739.8

JIANG Jian-lei, DAI Tian-guo, TIAN Zhuo-wei, WANG Li-zhen, HE Yue. The clinicopathological features of extra-orbital giant cell angiofibroma in oromaxillofacial head and neck region[J]. China Journal of Oral and Maxillofacial Surgery, 2015, 13(2): 161-166.

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The clinicopathological features of extra-orbital giant cell angiofibroma in oromaxillofacial head and neck region

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