中国口腔颌面外科杂志

中国口腔颌面外科杂志 ›› 2022, Vol. 20 ›› Issue (3): 263-267.doi: 10.19438/j.cjoms.2022.03.010

• 论著 • 上一篇    下一篇

MTA与PRF在上颌前牙拔牙患者牙槽骨再生中的应用效果评价

唐田1, 程群1, 丁子清1, 朱信灵1, 胡英英2   

  1. 1.杭州口腔医院 牙周病科, 浙江 杭州 310000;
    2.杭州口腔医院 特需专家门诊,浙江 杭州 310000
  • 收稿日期:2021-09-23 修回日期:2021-12-02 出版日期:2022-05-20 发布日期:2022-05-20
  • 通讯作者: 唐田,E-mail: h258469@126.com
  • 作者简介:唐田（1987-）,女,硕士,主治医师

Effect of mineral trioxide aggregate, autologous platelet-rich fibrin on alveolar bone regeneration in patients with maxillary anterior tooth extraction

TANG Tian; 1, CHENG Qun; 1, DING Zi-qing; 1, ZHU Xin-ling; 1, HU Ying-ying; 2   

  1. 1. Department of Periodontics, Hangzhou Stomatological Hospital. Hangzhou 310000, Zhejiang Province, China;
    2. Special Specialist Clinic, Hangzhou Stomatological Hospital. Hangzhou 310000, Zhejiang Province, China
  • Received:2021-09-23 Revised:2021-12-02 Online:2022-05-20 Published:2022-05-20

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摘要： 目的: 评价骨替代物矿物三氧化物骨料（MTA）与自体富血小板纤维蛋白（PRF）用于上颌前牙拔牙患者牙槽骨再生的效果。方法: 选择2017年1月—2019年12月杭州口腔医院收治的上颌前牙拔牙患者66例,根据填塞材料分为MTA组、PRF组、联合组（MTA+PRF）,每组各22例。获取术前和术后1、3、6、12个月的锥形束CT（CBCT）图像,比较3组患者损伤组织愈合、牙槽骨密度和牙槽骨体积。采用SPSS 21.0软件包对数据进行统计学分析。结果: 66例患者中,61例获得完整随访记录,随访率为92.42%,其中MTA组、PRF组、联合组分别为20例、20例、21例。3组患者术后3、6、12个月的牙槽骨密度显著高于术前（P<0.05）。联合组术后6、12个月的牙槽骨密度显著高于MTA组和PRF组（P<0.05）,MTA组术后6、12个月的牙槽骨密度显著高于PRF组（P<0.05）。3组患者术后3、6、12个月的牙槽骨体积显著低于术前（P<0.05）,联合组术后6个月、12个月的牙槽骨体积显著低于PRF组（P<0.05）。结论: MTA单独用于上颌前牙拔牙患者牙槽骨修复再生较单独使用PRF效果更好,而MTA与PRF联合应用具有更显著的牙槽骨修复再生效果,且长期效果稳定。

关键词: 矿物三氧化物骨料, 自体富血小板纤维蛋白, 牙槽骨再生, 牙槽骨密度, 牙槽骨体积

Abstract: PURPOSE: To investigate the effect of mineral trioxide aggregate (MTA) and autologous platelet-rich fibrin (PRF) on alveolar bone regeneration in patients with maxillary anterior tooth extraction. METHODS: Sixty-six patients receiving maxillary anterior tooth extraction in Hangzhou Stomatological Hospital from January 2017 to December 2019 were enrolled, and divided into 3 groups according to different filling materials: MTA group, PRF group and combined group, with 22 cases in each group. Cone-beam CT(CBCT) was performed before operation, 1, 3, 6 and 12 months after operation. Healing of injured tissue, alveolar bone density and alveolar bone volume were compared among 3 groups. The data were processed using SPSS 21.0 software package. RESULTS: A total of 61 patients completed the follow up(92.42%, 61/66), including 20 cases in MTA group, 20 cases in PRF group and 21 cases in combined group. Compared with the baseline data, MTA group, PRF group and combined group showed an increment in alveolar bone density 3, 6 and 12 months postoperatively (P<0.05). The alveolar bone density 6 and 12 months postoperatively in combined group were significantly higher than that in MTA group and PRF group(P<0.05), and the alveolar bone density 6 months and 12 months postoperatively in MTA group were significantly higher than that in PRF group. Alveolar bone volume showed a decrease in all 3 groups at postoperative 3, 6 and 12 months(P<0.05), alveolar bone volume of combined group at postoperative 6 and 12 months were significantly lower than that of PRF group(P<0.05). CONCLUSIONS: In single application, MTA has a better effect on restoration and regeneration of alveolar bone in patients with maxillary extraction than PRF, while combined application of the two has the best long-term effect in alveolar bone regeneration.

Key words: Mineral trioxide aggregate, Platelet-rich fibrin, Alveolar bone regeneration, Alveolar bone density, Alveolar bone volume

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