口腔颌面-头颈部眶外巨细胞血管纤维瘤的临床及病理特征分析

中国口腔颌面外科杂志 ›› 2015, Vol. 13 ›› Issue (2): 161-166.

口腔颌面-头颈部眶外巨细胞血管纤维瘤的临床及病理特征分析

蒋建磊¹, 代天国², 田卓炜², 王丽珍³, 何悦²

1.福建龙岩人民医院口腔科,福建龙岩 364000;
2.上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科;
3.口腔病理科,上海市口腔医学重点实验室,上海 200011

收稿日期:2014-04-04 修回日期:2014-06-12 出版日期:2015-03-20 发布日期:2015-04-23
通讯作者: 何悦,Tel:021-23271699-5656,E-mail:yuehe@sjtu.edu.cn
作者简介:蒋建磊(1971-),男,副主任医师,E-mail:jiangjianlei111@163.com
基金资助:
国家自然科学基金（81271112）; 上海市人才发展计划资助项目(201312); 上海交通大学晨星计划A类（201312）

The clinicopathological features of extra-orbital giant cell angiofibroma in oromaxillofacial head and neck region

JIANG Jian-lei¹, DAI Tian-guo², TIAN Zhuo-wei², WANG Li-zhen³, HE Yue²

1.Department of Stomatology, Fujian Longyan People's Hospital. Longyan 364000, Fujian Province;
2. Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology. Shanghai 200011, China;
3. Department of Oral Pathology, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology. Shanghai 200011, China

Received:2014-04-04 Revised:2014-06-12 Online:2015-03-20 Published:2015-04-23
Supported by:
Supported by National Natural Science Foundation of China (81271112), Development Foundation of Shanghai Municipal Human Resources and Social Security Bureau (201312) and SMC Rising Star-A Scholar of Shanghai Jiao Tong University(201312)

摘要/Abstract

摘要： 目的: 探讨口腔颌面-头颈部眶外巨细胞血管纤维瘤（extra-orbital giant cell angiofibroma,EO-GCA）的临床病理特征、鉴别诊断及治疗方法。方法: 收集整理Pubmed数据库中已报道的12例口腔颌面-头颈部EO-GCA文献资料,并结合我院2例患者的临床病理资料进行分析。结果: 14例患者（男9例,女5例）年龄24~84岁,平均43.5岁。肿瘤多数生长缓慢,大小与发生部位有关。镜下见肿瘤细胞呈卵圆形或短梭形,以富含血管和多核巨细胞为特征。免疫组织化学CD34及vimentin等间叶组织标志物呈阳性。临床极易误诊,确诊依赖于术后病理学检查,手术完整切除后复发少见。结论: 口腔颌面-头颈部EO-GCA是一种罕见的软组织良性肿瘤,临床易误诊,确诊依赖于组织病理学检查,手术完整切除后预后较好。

关键词: 口腔颌面-头颈部, 眶外巨细胞血管纤维瘤, 临床病理特征

Abstract: PURPOSE: To analyze the clinical features, histopathologic features, differential diagnosis and treatment of extra-orbital giant cell angiofibroma(EO-GCA) in oromaxillofacial head and neck region. METHODS: Data on 12 cases of EO-GCA reported in PubMed database and 2 cases in our hospital were collected and analyzed. RESULTS: Fourteen patients (nine females, five males) were included, their ages ranged from 24 to 84 years with an average age of 43.5 years. Most cases presented a slow-growing and painless mass. The size of the tumor was related to the anatomic location. Microscopic examination revealed a patternless ovoid or short spindle tumor cell, richly vascularized, and floret-like multinucleated giant cells. Immunohistochemical staining revealed strong positivity for the mesenchymal markers, such as CD34 and vimentin. Clinical misdiagnosis was common and final diagnosis relies on pathology. Complete surgical resection of the tumor can lead to a better prognosis and little local recurrence. CONCLUSIONS: EO-GCA in oromaxillofacial head and neck region is a rare benign soft tissue tumor easily misdiagnosed. Accurate diagnosis depends on histopathological examination. Complete surgical resection of the tumor has a better prognosis.

Key words: Oromaxillofacial head and neck region, Extra-orbital giant cell angiofibroma, Clinicopathological features

中图分类号:

R739.8

蒋建磊, 代天国, 田卓炜, 王丽珍, 何悦. 口腔颌面-头颈部眶外巨细胞血管纤维瘤的临床及病理特征分析[J]. 中国口腔颌面外科杂志, 2015, 13(2): 161-166.

JIANG Jian-lei, DAI Tian-guo, TIAN Zhuo-wei, WANG Li-zhen, HE Yue. The clinicopathological features of extra-orbital giant cell angiofibroma in oromaxillofacial head and neck region[J]. China J Oral Maxillofac Surg, 2015, 13(2): 161-166.

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