中国口腔颌面外科杂志 ›› 2014, Vol. 12 ›› Issue (6): 573-576.

• 病例报告 • 上一篇    

恶性婴儿型石骨症伴下颌骨骨髓炎1例报告及文献复习

王洁琪, 张大明, 郑美华, 陈伟良   

  1. 中山大学孙逸仙纪念医院 口腔科,广东 广州 510120
  • 收稿日期:2014-01-14 出版日期:2014-11-10 发布日期:2015-01-01
  • 通讯作者: 郑美华,Tel:020-81332985,E-mail:gzzhengm@sina.com
  • 作者简介:王洁琪(1988-),女,在读硕士研究生,E-mail:

Osteomyelitis of the mandible associated with malignant infantile osteopetrosis:a case report and literature review

WANG Jie-qi, ZHANG Da-ming, ZHENG Mei-hua, CHEN Wei-liang   

  1. Department of Stomatology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University. Guangzhou 510120, Guangdong Province, China
  • Received:2014-01-14 Online:2014-11-10 Published:2015-01-01

摘要: 石骨症是一种罕见的先天性遗传疾病,其发病特征为破骨细胞受损导致的全身骨密度增加。常染色体隐性遗传恶性石骨症又称为恶性婴儿型石骨症,其发病率约为1/300000。本文报告1例恶性婴儿型石骨症伴下颌骨骨髓炎病例,并结合文献对石骨症的发病机制、临床表现、影像学表现及治疗等进行综述。

关键词: 石骨症, 恶性婴儿型石骨症, 下颌骨骨髓炎

Abstract: Osteopetrosis is a rare congenital genetic disease characterized by increased bone density due to impaired bone resorption by osteoclasts. The incidence of autosomal recessive osteopetrosis, also called malignant infantile osteopetrosis, is 1:300000. This article presented a typical case of osteomyelitis of the mandible associated with malignant infantile osteopetrosis, and reviewed the relevant literature on the pathogenesis, clinical manifestations, radiological feature and treatment of osteopetrosis.

Key words: Osteopetrosis, Malignant infantile osteopetrosis, Osteomyelitis of the mandible

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