星形细胞上调基因1在唾液腺肿瘤中的表达和意义

中国口腔颌面外科杂志 ›› 2014, Vol. 12 ›› Issue (1): 35-38.

星形细胞上调基因1在唾液腺肿瘤中的表达和意义

陈垂史¹, 黄志权², 李海刚³

1.深圳市龙岗区中心医院口腔科,广东深圳 518116; 2.中山大学孙逸仙纪念医院口腔颌面外科,广东广州 510120; 2.中山大学孙逸仙纪念医院病理科,广东广州 510120

收稿日期:2013-05-15 修回日期:2013-07-17 出版日期:2014-02-10 发布日期:2014-02-10
通讯作者: 黄志权,E-mail：zhiquanhuang1978@126.com
作者简介:陈垂史（1978-）,男,副主任医师,E-mail:524333789@qq.com
基金资助:
国家自然科学基金(81101592); 广东省自然科学基金(S2013010014794)

The expression and significance of astrocyte elevated gene-1 in salivary gland tumors

CHEN Chui-shi¹, HUANG Zhi-quan¹, LI Hai-gang¹

1.Department of Stomatology, Shenzhen Longgang Central Hospital. Shenzhen 518116; 2. Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. Guangzhou 510120, Guangdong Province, China; 3. Department of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. Guangzhou 510120, Guangdong Province, China

Received:2013-05-15 Revised:2013-07-17 Online:2014-02-10 Published:2014-02-10
Supported by:
Supported by National Natural Science Foundation of China(81101592) and Natural Science Foundation of Guangdong Province (S2013010014794).

摘要/Abstract

摘要： 目的: 探讨星形细胞上调基因1(astrocyte elevated gene-1,AEG-1)在唾液腺肿瘤中的表达和意义。方法：免疫组化检测唾液腺良性肿瘤(多形性腺瘤)、恶性肿瘤(黏液表皮样癌和腺样囊性癌)组织中AEG-1的表达,探讨AEG-1的表达与唾液腺肿瘤临床病理特征的相关性。选取同期15例非肿瘤手术切除的正常唾液腺组织作为对照。采用SPSS10.0软件包对数据进行统计学分析。结果：肿瘤组织中AEG-1阳性率显著高于正常唾液腺组织(P=0.001),恶性肿瘤组AEG-1的阳性率显著高于良性肿瘤组织(P=0.033),晚期恶性肿瘤(T3+T4)AEG-1阳性率显著高于早期肿瘤(T1+T2)(P=0.035)。结论：AEG-1可能在唾液腺肿瘤的发生和恶变过程中起着一定作用。

关键词: 星形细胞上调基因1, 唾液腺肿瘤, 免疫组化染色

Abstract: PURPOSE: To explore the expression and significance of astrocyte elevated gene-1 (AEG-1) in salivary gland tumors. METHODS: The expression of AEG-1 was detected by immunohistochemistry in salivary gland tumors (including pleomorphic adenoma, mucopidermoid carcinoma, and adenoid cystic carcinoma), as well as 15 cases of normal salivary gland tissue. SPSS 10.0 software package was used for statistical analysis. RESULTS: AEG-1 expression in tumor tissue was significantly higher than that in normal salivary gland tissue (P=0.001). AEG-1 expression in malignant tumors was significantly higher than that in pleomorphic adenoma (P=0.033). The expression of AEG-1 was related to tumor stage in malignant tumors (P=0.035). CONCLUSIONS: The expression of AEG-1 may contribute to salivary gland tumor development and malignant potentiality.

Key words: Astrocyte elevated gene-1, Salivary gland tumor, Immunohistochemistry

陈垂史, 黄志权, 李海刚. 星形细胞上调基因1在唾液腺肿瘤中的表达和意义[J]. 中国口腔颌面外科杂志, 2014, 12(1): 35-38.

CHEN Chui-shi, HUANG Zhi-quan, LI Hai-gang. The expression and significance of astrocyte elevated gene-1 in salivary gland tumors[J]. China J Oral Maxillofac Surg, 2014, 12(1): 35-38.

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