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20 May 2020, Volume 18 Issue 3 Previous Issue    Next Issue

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Expert Consensus

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Chinese expert consensus on ultrasound hyperthermia for oral and maxillofacial head and neck squamous cell carcinoma JU Hou-yu, ZHENG Jia-wei, SUN Mo-yi, TANG Zhan-gui, YANG Dao-ke, RAN Wei, BU Rong-fa, SHANG Wei, MENG Jian, WU He-ming, XI Qing, YANG Kai, WANG Jun, WU Yun-teng, REN Guo-xin, GUO Wei 2020, 18 (3):  193-198.  doi: 10.19438/j.cjoms.2020.03.001 Abstract ( 692 )   HTML ( 99 )   PDF (5082KB) ( 366 )   Most patients with oral and maxillofacial malignancy, especially squamous cell carcinoma(SCC) are in the middle and advanced stages at diagnosis. Chemotherapy alone is difficult to benefit the survival of patients with advanced oral and maxillofacial SCC. Ultrasound hyperthermia is a new and effective treatment for malignant tumor, which is developing rapidly in addition to conventional treatment. However, at present, ultrasound hyperthermia has not been widely used in the treatment of oromaxillofacial head and neck SCC. Therefore, formation of an expert consensus on ultrasound hyperthermia for oromaxillofacial head and neck SCC is mandatory, in order to promote and standardize the clinical practice of ultrasound hyperthermia in this field, and improve the long-term survival rate and quality of life of patients. References | Related Articles | Metrics

Special Topic on COVID-19

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Suggestions for how to prevent coronavirus disease 2019 during oral surgeries XUE Yang, HAN Bing, PAN Jian, ZHOU Hong-zhi, ZHOU Qing, ZHAO Ji-hong, CHEN Song-ling, ZHANG Wei, ZOU Duo-hong, LIU Chang-kui, HU Kai-jin 2020, 18 (3):  199-203.  doi: 10.19438/j.cjoms.2020.03.002 Abstract ( 464 )   HTML ( 28 )   PDF (3883KB) ( 162 )   With current outbreak and spread of coronavirus disease 2019 (COVID-19), it was recognized that there was a great risk of infection during the process of diagnosis and treatment of oral diseases. As a result, all the optional oral and dental treatments were suspended. However, the staff in the field of oral surgery are on their duties and responsible for the emergent treatment of oral and maxillofacial trauma, infection and extraction of teeth with severe pain that can't be retained. Here, we proposed informative suggestions on the indications requiring emergent treatment, treatment principles, risk assessment, patient preparation, protection of the surgeons and nurses, with the hope to help doctors and nurses who carry out oral surgeries during this special period. References | Related Articles | Metrics

Special Topic on COVID-20

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Nursing strategy of oral and maxillofacial trauma emergency during epidemic situation of the novel coronavirus pneumonia LIU Ting, YUAN Wei-jun, WANG Xu-dong, XIAO Yan, YU Li-ya 2020, 18 (3):  204-209.  doi: 10.19438/j.cjoms.2020.03.003 Abstract ( 416 )   HTML ( 25 )   PDF (4479KB) ( 438 )   The outbreak of the coronavirus disease 2019(COVID-19) is still in a severe stage. Due to the particularity and urgency for oral and maxillofacial trauma, health providers in the emergency department face the potential risk of infection of COVID-19. Nursing work plays an important role in the implement of diagnosis and treatment of emergency trauma. It is critical to cooperate with all team-members, respond to emergency situation positively and correctively;; at the same time, to prevent the infection and spread of COVID-19. This article discussed the nursing strategy of emergency oral and maxillofacial trauma, based on the experiences from the Department of Oral and Craniomaxillofacial Surgery in Shanghai Ninth People's Hospital, which is aimed to provide some references for clinical work. References | Related Articles | Metrics

Special Topic on COVID-21

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Development of anti-spray isolation device for critically ill 2019-nCoV patients who received tracheotomy WU Jia-jun, XIA Wei-liang, FAN Jing-xian, LI Ying-chuan, WEI Xian, GUO Chang-feng, Huang Jie, XU Bing, LU Hong-zhou 2020, 18 (3):  210-213.  doi: 10.19438/j.cjoms.2020.03.004 Abstract ( 266 )   PDF (2842KB) ( 192 )   PURPOSE: High risk procedures such as intubation, tracheotomy for critically ill 2019-nCoV patients were one of the most important factors that increased the risk of healthcare workers (HCWs)'s infection. METHODS: One anti-spray isolation device was developed to reduce virus infection during high risk procedures. Operators performed surgery through two holes on the isolation device, while not affected. RESULTS: This isolation device was patent and applied successfully in seven critically ill 2019-nCoV patients who received tracheotomy. Then it went into production and had been transported to Wuhan medical institutions. CONCLUSIONS: At present, this isolation device had been used in clinical practice and received good feedback. It was believed that the device would provide well protection for front-line HCWs and reduce their infection risk. References | Related Articles | Metrics

Original Articles

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Decrease of pain threshold of trigeminal nerve induced by reactivation of latent trigeminal ganglia infection of herpes simplex virus type 1 in SD rats LIU Run-ze, YANG Yan-ling, XUE Jin-lang, FANG Zhuo-ran, WANG Yun, DENG Chao, CHEN Chuan-jun 2020, 18 (3):  214-218.  doi: 10.19438/j.cjoms.2020.03.005 Abstract ( 384 )   PDF (3840KB) ( 230 )   PURPOSE: To establish an animal model of latent infection and reactivation of trigeminal ganglia caused by herpes simplex virus type 1 (HSV-1) in SD rats. The effect of HSV-1 infection and reactivation of ganglion on pain threshold of trigeminal nerve was observed by pain threshold test. METHODS: SD rats were randomly divided into the experimental group and the control group. Rats in the experimental group were treated by corneal scratch with HSV-1 to establish latent infection model of ganglion, while rats in the control group were treated by corneal scratch with normal saline. After 8 weeks, the rats in the experimental group were divided into ultraviolet irradiation group and non ultraviolet irradiation group, ultraviolet irradiation was used to induce reactivation of HSV-1. The mechanical pain threshold of each group of rats was measured by von Frey filament pain threshold detector. The expression levels of HSV-gD, LAT and ICP27 were detected by RT-PCR to verify the success of latent infection and reactivation of HSV-1 in ganglion. RESULTS: Latency and reactivation of HSV-1 in ganglion were successful fulfilled in rats; pain like stimulation reaction occurred in rats of the experimental group and pain threshold decreased both in latency and reactivation,especially in reactivation. CONCLUSIONS: Reactivation of latent infection of HSV-1 in trigeminal ganglia can induce the decrease of trigeminal neuralgia threshold, which suggests that HSV-1 may be the cause of trigeminal neuralgia. References | Related Articles | Metrics

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Application of PEGS/β-TCP membrane in promoting bone regeneration of rat calvarial defect ZHI Yin, YU Shuang, SHEN Hong-zhou, SI Jia-wen, YUAN Yuan, SHI Jun, LIU Chang-sheng 2020, 18 (3):  219-225.  doi: 10.19438/j.cjoms.2020.03.006 Abstract ( 304 )   PDF (5551KB) ( 181 )   PURPOSE: The purpose of this study was to explore the effect of PEGS/β-TCP membrane on guided bone regeneration. METHODS: PEGS/β-TCP membrane was co-cultured with rat bone marrow mesenchymal stem cells (rBMSCs) to observe cell adhesion, proliferation and osteogenic differentiation. Animal model of rat skull defect was established, and PEGS/β-TCP membrane was implanted in the area of the defect. Micro-CT was used to observe the formation of new bone in bone defect area, and H-E staining of decalcified tissue was used to observe the degree of inflammatory infiltration and new bone formation. Statistical analysis was performed with SPSS 22.0 software package. RESULTS: rBMSCs can be well adhered and widely distributed on PEGS/β-TCP membrane. Quantitative analysis of dsDNA at 1, 4 and 7 days showed that the DNA content in both groups increased from day 1 to day 7, and there was significant difference between the control group and the experimental group at day 7 (P<0.001). Alkaline phosphatase (ALP) activity of rBMSCs on PEGS/β-TCP membrane increased significantly after osteogenic induction in vitro. ALP activity of the experimental group was significantly higher than that of the control group (P<0.01). The results of Alizarin red mineralization staining and ALP staining showed the same trend at day 21. Micro-CT examination and H-E staining showed that the formation of new bone in the experimental group was significantly higher than that in the control group, and the inflammatory reaction in each group was mild. CONCLUSIONS: This study shows that PEGS/β-TCP composite membrane had ideal cytocompatibility and guided bone regeneration effect, which provides theoretical support for further study and application of PEGS/β-TCP membrane in guided bone regeneration. References | Related Articles | Metrics

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Risk factors analysis of delirium after head and neck reconstruction in 238 consecutive cases LI Xiao-dong, MENG Jian, ZHANG Ling, YE Wei-min 2020, 18 (3):  226-230.  doi: 10.19438/j.cjoms.2020.03.007 Abstract ( 344 )   PDF (3836KB) ( 345 )   PURPOSE: To observe and analyze the risk factors of postoperative delirium in patients undergoing head and neck reconstruction after tumor surgery. METHODS: From October 2018 to October 2019, 238 patients with head and neck reconstruction at the Department of Oromaxillofacial Head and Neck Oncology of Shanghai Ninth People's Hospital were included in this study. Among 238 cases, 160 were male and 78 were female. The average age was 56.52±15.31 years (rage: 16 to 85). According to postoperative results evaluated with Confusion Assessment Method (CAM), they were divided into delirium group and control group. The incidence and related risk factors of delirium were analyzed using SPSS 17.0 software package. RESULTS: The incidence of delirium after head and neck reconstruction was 10.1%(24/238). Single factor analysis results showed that delirium was associated with advanced age, hypertension, history of delirium, preoperative sleep disorder, postoperative sleep disorder, intraoperative blood transfusion and postoperative pain. Multiplelogistic regression analysis indicated that the perioperative risk factors of delirium included advanced age(OR=1.090), postoperative sleep disorder (OR=15.248), intraoperative blood transfusion (OR=1.003), and postoperative pain (OR=1.398). CONCLUSIONS: Patients with advanced age, intraoperative blood transfusion, postoperative sleep disorder and postoperative pain are the high risk groups for delirium after head and neck reconstruction. Active preventive measures should be taken to reduce the occurrence of postoperative delirium. References | Related Articles | Metrics

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The effect of preoperative prophylactic antibiotics on dental implants in patients with type 2 diabetes mellitus: 3-5-years retrospective study RUAN Dan-ping, YANG Yi-chen, DENG Si-nan, ZHAO Yuan-yuan, WU Chun-yun 2020, 18 (3):  231-235.  doi: 10.19438/j.cjoms.2020.03.008 Abstract ( 372 )   PDF (3732KB) ( 204 )   PURPOSE: To evaluate the effect of preoperative antibiotic application on the effect of dental implantation in patients with good controlled blood glucose and mild poor controlled type 2 diabetes mellitus (T2DM), and to study the necessity of preoperative prophylactic use of antibiotics. METHODS: According to the inclusion criteria of this study, we reviewed T2DM patients with good controlled and mildly poor controlled T2DM, who received dental implant from May 2014 to May 2016. The patients were followed regularlly, then clinical examination and radiographic evaluation were carried out. The differences between groups were analyzed by t test and Chi-square test respectively with SPSS 20.0 software package. Kaplan-Meier method was used to calculate survival rate. RESULTS: A total of 57 T2DM patients were included in this retrospect study, including 30 patients in the group with good blood glucose control (13 patients with medication, 17 patients without medication), 27 patients in the group with mild poorly blood glucose control(15 patients with medication, 12 patients without medication). The wounds healed well and no infection was found in all patients. During the follow-up period, there was no significant difference in implant survival rate, bleeding on probing%, modified plaque index, periimplant probing depth and marginal bone loss. CONCLUSIONS: Prophylactic use of antibiotics before dental implantation surgery can not improve wound healing, long-term survival rate and marginal bone loss. There is a lack of evidence to support the necessity of systemic antibiotic prophylaxis in T2DM patients with good and mild poorly controlled blood glucose. References | Related Articles | Metrics

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Effect of guided bone regeneration on gingival aesthetics and alveolar bone resorption of dental implants in the anterior region QIN Kun, LIU Hong-hong, ZHANG Run-yu, ZHANG Zhi-hong 2020, 18 (3):  236-239.  doi: 10.19438/j.cjoms.2020.03.009 Abstract ( 417 )   PDF (3403KB) ( 310 )   PURPOSE: To understand whether guided bone regeneration (GBR) can be used in patients with bone defects at the implantation site in the anesthetic area of the anterior teeth to obtain similar gingival aesthetic effects in patients without obvious bone defects after implantation, and to evaluate the effects of GBR on bone alveolar resorption. METHODS: A total of 31 patients who underwent anterior dental implantation at the Stomatology Center of the First Affiliated Hospital of the University of Science and Technology of China (Anhui Provincial Hospital) from August 2017 to June 2018 were selected. The width of the alveolar bone at the implantation site was measured in all 31 patients before surgery. The patients with a width of less than 6.8 mm were in the GBR group, and the patients with a width of more than 6.8 mm were in the non-GBR group. The two groups of patients were compared for gingival esthetic score, probing depth and alveolar bone resorption during the second-stage restoration. SPSS 19.0 software package was used to perform two independent sample t tests on the data. RESULTS: The gingival aesthetic score of the GBR group was significantly higher than that of the non-GBR group(P<0.01). There was no significant difference in the probing depth between the GBR group and the non-GBR group(P>0.05). Alveolar bone resorption in the GBR group was significantly smaller than that in the non-GBR group(P<0.01). CONCLUSIONS: The use of GBR can slow down the rate of bone resorption and make the patients with local alveolar bone defect reach the similar aesthetic effect of patients without alveolar bone defect after dental implantation. References | Related Articles | Metrics

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Effects of intranasal midazolam spray as premedication on epileptiform EEG in children during induction with sevoflurane SUO Lu-lu, BAO Yong-yang, SUN Yu 2020, 18 (3):  240-244.  doi: 10.19438/j.cjoms.2020.03.010 Abstract ( 339 )   PDF (3907KB) ( 222 )   PURPOSE: This clinical trial was performed to evaluate the effects of intranasal midazolam spray as premedication on the incidence of epileptiform EEG activity during induction with sevoflurane in children. METHODS: Eighty-six patients(0.5-6 years, ASA Ⅰ-Ⅱ) undergoing elective oral and maxillofacial surgery under general anesthesia were randomly allocated to two different premedication groups: midazolam group and normal saline group. After intranasal premedication spray in the waiting area, the patients were transferred to the operating room. The patients were anesthetized with 8% sevoflurane via face mask. EEGs during induction were continuously recorded and analyzed. Statistical analysis was performed using SPSS 25 software package. RESULTS: Twenty-three patients (53%, DSP30%, PSR37%, PED9%) in midazolam group had epileptiform EEG patterns compared to 29 patients (67%, DSP37%, PSR35%, PED19%) in normal saline group (P=0.186). The time from start of sevoflurane until loss of consciousness was shorter in midazolam group than in normal saline group, but the difference was not significant [(41.6±11.0)s vs (44.1±16.1)s,P=0.409]. CONCLUSIONS: 0.4 mg/kg midazolam intranasal spray before operation can not reduce the occurrence of epileptiform EEG in children during sevoflurane induction. References | Related Articles | Metrics

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A comparative study on the evaluation of velopharyngeal insufficiency with lateral cephalometric radiographs and nasopharynx fiberscope PENG Zhao-wei, ZHONG Tian-hang, HAN Jian-li, KUANG Yi-yuan, MA Lian 2020, 18 (3):  245-249.  doi: 10.19438/j.cjoms.2020.03.011 Abstract ( 327 )   PDF (3714KB) ( 193 )   PURPOSE: To explore the consistency between lateral cephalometric radiographs and nasopharynx fiberscope in determination of velopharyngeal insufficiency of different types of motion (coronary, sagittal and annular), and the application of lateral cephalometric radiographs in determination of velopharyngeal insufficiency. METHODS: Eighty-seven eligible patients with palatoplasty were evaluated by nasopharynx fiberscope and lateral cephalometric radiographs respectively, and the results were analyzed by paired t test, Pearson’s correlation analysis and kappa consistency test with SPSS 13.0 software package. RESULTS: There was a strong positive linear correlation between rate of velopharyngeal insufficiency (RVPI) and rate of velopharyngeal sagittal restriction (RVSR) (Pearson’s correlation coefficient 0.695, P< 0.01), in which there was a strong positive linear correlation between RVPI and RVSR in the coronary closure group and annular closure group (Pearson’s correlation coefficient 0.678 and 0.728, P<0.01), and a weak correlation between RVPI and RVSR in the sagittal closure group (Pearson’s correlation coefficient 0.409, P>0.05）. The kappa value of the two evaluation methods was 0.597, and the consistency of the two evaluation methods is moderate; the kappa value of the two evaluation methods in the coronary closure group was 0.630, the kappa value of the two evaluation methods in the sagittal closure group was 0.667, and the kappa value of the two evaluation methods in the annular closure group was 0.534. CONCLUSIONS: Lateral cephalometric radiographs is a reliable method to evaluate velopharyngeal function, and the degree of anastomose with nasopharynx fiberscope method is moderate, which is related to the type of closure. Lateral cephalometric radiographs can be used as a screening method for velopharyngeal insufficiency in clinical practice. When it is inconsistent with subjective evaluation, it should be comprehensively evaluated with nasopharynx fiberscope. References | Related Articles | Metrics

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Relationship between occlusal plane with upper airway morphological function and hyoid bone location as well as its application in orthodontic treatment of patients with malocclusion WANG Wei, HUANG Jia-xin, ZHU Xing-yao 2020, 18 (3):  250-254.  doi: 10.19438/j.cjoms.2020.03.012 Abstract ( 297 )   PDF (3444KB) ( 155 )   PURPOSE: To study the correlation between occlusal plane, upper airway morphological function and hyoid bone location along with its application in orthodontic treatment of patients with malocclusion. METHODS: A total of 120 patients with Angle Class I malocclusion who underwent orthodontic treatment in our hospital from January 2014 to January 2019 were randomly enrolled. All subjects were observed before and 3 months after orthodontic treatment. Changes in upper airway morphological function indicators (SNA, SNB, ANB, SPPS, MPS, IPS, S-PNS, Ba-PNS) were recorded. Based on the occlusal plane angle (OP-SN) values, they were divided into group A (35 cases, 10°≤OP-SN<15°), group B (45 cases, 15°≤OP-SN<20°), and group C (40 cases, 20°≤OP-SN<25°). The changes in sleep monitoring indexes (mean oxygen saturation MSaO2; minimum oxygen saturation LSaO2; desaturation index, average pulse rate) and different occlusal plane angle (OP-SN), as well as upper airway morphological functional indexes (SNA, SNB, ANB, SPPS, MPS, IPS, S-PNS, Ba-PNS) and hyoid bone location(H-PS, H-VPS) 3 months after treatment were measured. Pearson correlation analysis was used to analyze the relationship between occlusion plane and upper airway morphological function and hyoid bone location with SPSS 20.0 software package. RESULTS: The upper airway morphological functions of SNA, MPS, IPS, S-PNS and Ba-PNS were improved after treatment, the upper airway morphological functions of SNB, ANB and SPPS were decreased compared with those before treatment (P<0.05). The angles of OP-SN and ANB in three different occlusal plans were increased with the increase of the angle of the occlusal plane, while the SNA and SNB angles were decreased with the increase of angle of the occlusal plane (P<0.05). OP-SN was negatively correlated with SNA and SNB (P<0.05), and positively correlated with ANB (P<0.05). The upper airway morphological function indicators of SNA, SNB, ANB, SPPS, MPS, TPS were positively correlated with H-PS and H-VPS (P<0.05). CONCLUSIONS: The occlusal plane in patients with Angle Class I malocclusion is closely related to upper airway morphological function and the position of hyoid bone. References | Related Articles | Metrics

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Effect of non-syndromic cleft lip with or without cleft palate on oral health-related quality of life ZHANG Wen-jing, WANG Xia 2020, 18 (3):  255-259.  doi: 10.19438/j.cjoms.2020.03.013 Abstract ( 232 )   PDF (3561KB) ( 177 )   PURPOSE: To investigate the effects of non-syndromic cleft lip with or without cleft palate (NSCL/P) on oral health-related quality of life. METHODS: The clinical data of 90 children with non-syndromic cleft lip with or without cleft palate treated from January 2017 to June 2019 were retrospectively analyzed, including 52 cases of cleft lip without cleft palate (cleft lip without cleft palate group) and 38 cases of cleft lip with cleft palate (cleft lip with cleft palate group).Meanwhile, 40 children with oral health who underwent routine oral examination in our hospital in the same period were selected as the control group. Oral health examinations were conducted in all children, questionnaires were used to assess the impact of oral health on daily life. SPSS 22.0 software package was used to analyze the correlation between oral health and quality of daily life. RESULTS: There were significant differences in the number of decay miss fill, tissue health index, caries and LOA ≥6 mm between cleft lip without cleft palate group and cleft lip with cleft palate group (P<0.05), and the scores of those two groups were significantly higher than the control group (P<0.05). The scores of each items and total OIDP scores in cleft lip with cleft palate group were significantly higher than those in cleft lip without cleft palate group (P<0.05), and the sores in cleft lip without cleft palate group was significantly higher than the control group (P<0.05). Spearman correlation analysis showed negative correlation between DMFT, MT and root caries, LOA≥6 mm teeth and OIDP score in cleft lip and palate without cleft palate group and cleft lip with cleft palate group, and a positive correlation between occlusal teethⅠand occlusal teethⅡand OIDP score (P<0.05). CONCLUSIONS: Oral health problems in children with NSCL/P have various impacts on their quality of daily life. References | Related Articles | Metrics

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Minimally invasive tooth extraction of impacted wisdom teeth and its impact on VAS score and stress response CHANG Zhong-fu, LU Li-quan, JIANG Dan-dan, ZHANG Zhi-rong, CAI Jian-ying, ZHANG Li-hua 2020, 18 (3):  260-263.  doi: 10.19438/j.cjoms.2020.03.014 Abstract ( 395 )   PDF (3166KB) ( 229 )   PURPOSE: To explore the clinical effect of minimally invasive extraction on impacted wisdom teeth and its impact on VAS score and stress response. METHODS: A total of 98 patients in our hospital from July 2017 to July 2019 who needed to remove impacted wisdom teeth were selected and randomly divided into control group and experimental group, 49 cases in each group. Conventional extraction method was adopted in the control group, while minimally invasive extraction method was used in the experimental group. The surgical effect, changes in the levels of inflammatory mediators, stress mediators in the gingival crevicular fluid, and postoperative complications were compared. The data were analyzed using SPSS 18.0 software package. RESULTS: The operation time, pain, swelling and mouth opening degree of the experimental group were significantly better than those of the control group (P<0.05); the contents of PTX3, ICAM1, MPO, and PGE2 in the experimental group were significantly lower than those in the control group(P<0.05). After treatment, the contents of PPARr, ROS, and MDA in the experimental group were significantly lower than those in the control group(P<0.05); the contents of GPx and T-AOC in the experimental group were significantly higher than those in the control group(P<0.05). The incidences of symptoms, restricted mouth openings, edema, and infection of the experimental group were significantly lower than those in the control group (P<0.05). CONCLUSIONS: Minimally invasive tooth extraction has significant advantages in the extraction of impacted wisdom teeth. It can shorten operation time, help reduce the pain of patients, reduce inflammatory stress response, postoperative response is milder, and postoperative complications were reduced. References | Related Articles | Metrics

Clinical Reports

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Oral propranolol combined with topical betaxolol for 8 children with high-risk infantile hemangiomas involving periocular region LI Hong, ZHOU Yu-chuan, GONG Zhong-cheng, SUN Yang, LING Bin 2020, 18 (3):  264-268.  doi: 10.19438/j.cjoms.2020.03.015 Abstract ( 418 )   PDF (3824KB) ( 195 )   PURPOSE: To assess the efficacy and safety of oral propranolol combined with betaxolol for high-risk infantile hemangiomas involving periocular region. METHODS: From August 2014 to January 2019 in 8 pediatric patients with high-risk hemangiomas, propranolol was administered orally at a daily dose of 0.5-2 mg/kg, betaxolol was applied to the tumor surface for ten minutes twice a day. The treatment lasted for half to one year or until a full recovery was achieved. The efficiency and safety of this treatment was assessed based on the changes of size, thickness, color, local peak systolic velocity before and after treatment and side effects during the therapy. SPSS 23.0 software package was used for statistical analysis. RESELTS: The mean treatment duration was 9.4 months and the mean score of efficacy was 77 points of 8 patients. The clinical response were evaluated as four patients for grade Ⅳ and another four for grade Ⅲ. No severe complications were observed. CONCLUSIONS: Oral propranolol combined with topical betaxolol is an effective and safe treatment for high-risk infantile hemangiomas involving periocular region. References | Related Articles | Metrics

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Application of intraoperative CT in the treatment of temporomandibular joint ankylosis MA Dong-yang, PANG Chao-yuan, ZHANG Wen-kai, WANG Bing-wu, LIU Ya-li, YANG Yang 2020, 18 (3):  269-271.  doi: 10.19438/j.cjoms.2020.03.016 Abstract ( 310 )   PDF (2463KB) ( 164 )   PURPOSE: To investigate the application and value of intraoperative CT in the treatment of temporomandibular joint (TMJ) ankylosis. METHODS: Four patients (5 sides) who underwent surgery of TMJ ankylosis using intraoperative CT from July 2016 to December 2018 were retrospectively studied. Demographics, surgical factors, and clinical outcomes were analysed. RESULTS: All 4 patients were successfully operated with the aid of intraoperative CT imaging and CT-directed revisions were made in three of them during surgery. The average time spent in scanning was (10.2±3.3) minutes. No surgical complications were noted and a good satisfaction rate (with an average mouth opening of 38.8 mm) was obtained. CONCLUSIONS: Intraoperative CT scanning is a useful tool in evaluation of the surgical results of TMJ ankylosis, and a real-time revision could be made. It increased precision and safety of the surgery of TMJ ankylosis. References | Related Articles | Metrics

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Accurate implantation of 125I seeds guided by digital navigation for the treatment of 9 patients with adenogenous malignant tumors of the skull base GE Sheng-you, ZHOU Kai, KONG Yu, GAO Ce, SONG Kai, FENG Yuan-yong, SHANG Wei 2020, 18 (3):  272-277.  doi: 10.19438/j.cjoms.2020.03.017 Abstract ( 273 )   PDF (4679KB) ( 197 )   PURPOSE: To investigate the feasibility and efficacy of accurate implantation of 125I seeds guided by digital navigation for the treatment of adenogenous malignant tumors of the skull base. METHODS: A series of 9 patients received digital navigation guided interstitial 125I seeds implantation. CT scanning was performed precisely and the plan of 125I implantation was designed systematically with the aid of Treatment Planning System(TPS) and AccuNavi-A navigation system. 125I was delivered into the target region according to the position and direction defined by the designed implantation plan and digital navigation during the process of implantation. Real-time assessment was required to find if the position of 125I corresponded with preoperative plan. All patients underwent regular reexamination to compare the tumor size preoperatively and postoperatively. The recurrent rate and local control rate were evaluated and the adverse events observed. RESULTS: 125I seeds were implanted successfully in target-area of all 9 patients. The recurrence rate was 11.1% and the local control rate (CR+PR) was 77.8% without severe side effects during follow-up at 3-36 months in all patients. CONCLUSIONS: Traditional resection carried a high risk of postoperative complications because the base of the skull is concealed, with a narrow space and limited field of vision. Accurate implantation of 125I with the use of digital navigation imaging guidance is an effective,minimally invasive and safe method for treating adenogenous malignant tumors of the skull base and should be considered for conditional use. References | Related Articles | Metrics

Review Articles

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Advances in the relationship between oral microbe and oral squamous cell carcinoma LIU Yuan, ZHANG Ling 2020, 18 (3):  278-284.  doi: 10.19438/j.cjoms.2020.03.018 Abstract ( 404 )   PDF (6527KB) ( 372 )   Oral microflora plays an important role in human microflora and human health, the imbalance between microbes and their hosts leads to oral and systemic diseases. Some tumors have been considered to be related to the existence of bacteria and other microorganisms, and the relationship between oral tumors and microorganisms has been gradually recognized. This paper reviewed the relationship between oral squamous cell carcinoma and oral microorganisms, and expounded the possible pathway of oral squamous cell carcinoma caused by oral microorganisms and the influence of oral squamous cell carcinoma microenvironment on microorganisms, in order to provide reference for further research on the relationship between oral microbe and tumor, so as to realize the purpose of early diagnosis of oral squamous cell carcinoma and even adjuvant therapy.; References | Related Articles | Metrics

Case Reports

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Primary central intraosseous squamous cell carcinoma of the mandible: A case report and literature review ZHANG Hong-wei, TAO Chuan-si-bo, WANG Dian-can 2020, 18 (3):  285-288.  doi: 10.19438/j.cjoms.2020.03.019 Abstract ( 786 )   PDF (3115KB) ( 244 )   Primary intraosseous squamous cell carcinoma is a rare malignant central jaw tumor derived from odontogenic epithelial remnants. This paper reported a case with intraosseous squamous cell carcinoma affecting the right mandible. The patient presented with persistent unhealing right mandibular tooth extraction wound, accompanied by granulation tissue formation and local pain, which did not affect the function of eating and speech. Right free vascularized fibula musculocutaneous flap was used for repair of the defects after surgical resection, and postoperative pathology confirmed squamous cell carcinoma. References | Related Articles | Metrics