Table of Content

20 January 2019, Volume 17 Issue 1 Previous Issue    Next Issue

For Selected:

Download Citations EndNote Ris BibTeX

Toggle Thumbnails

Editorial

Select

Functionally superior new classification of mandibular defects (COM) and its clinical application ZHANG Chen-ping, RUAN Min, LIU Jian-nan, YANG Xi, LI Si-yi, QU Xing-zhou,JI Tong 2019, 17 (1):  1-6.  doi: 10.19438/j.cjoms.2019.01.001 Abstract ( 475 )   PDF (4477KB) ( 358 )   Mandibular defects are mostly caused by resection of benign and malignant tumors, trauma and infection, which can lead to different degrees of facial deformity and physiological dysfunction. Mandibular defects are complex, and different parts and ranges of defects will produce different degrees of morphological and functional damage, and the subsequent repair and reconstruction difficulties are also different. Therefore, accurate classification of mandibular defects is of great significance for functional reconstruction and postoperative rehabilitation. Based on a large number of previous clinical practices, this paper proposed a new classification method for mandibular defects based on three different functional areas: condyle region, occlusion region and muscle region, namely COM method. It is elaborated here and hopes to help repair guidance and prediction of rehabilitation effects. References | Related Articles | Metrics

Expert Consensus

Select

Chinese expert consensus on chrono-chemotherapy for oral squamous cell carcinoma YANG Kai, GUO Wei, SUN Mo-yi, ZHENG Jia-wei, LI Long-jiang, TANG Zhan-gui, REN Guo-xin, CHEN Dan, LV Xiao-qiang, ZHANG Jie, HAN Zheng-xue, XI Qing, SUN Zhi-jun, CHEN Xiao-pin, ZHANG Tao, CHE Zong-gang, RAN Wei, MENG Jian, HUANG Gui-lin, TANG Hong, XIAO Can 2019, 17 (1):  7-12.  doi: 10.19438/j.cjoms.2019.01.002 Abstract ( 702 )   PDF (4904KB) ( 369 )   Chemotherapy is one of the main methods for treatment of oral squamous cell carcinoma, and it is also an important part of comprehensive treatment of oral squamous cell carcinoma. However, the "double-edged sword" effect of chemotherapeutic drugs in killing both cancer cells and normal cells in vivo has restricted its clinical application to a certain extent. Chrono-chemotherapy based on human circadian rhythm is safer and more effective than traditional chemotherapy, which has been confirmed by a large number of studies. In order to promote and standardize the clinical application of this technology, we organized relevant experts to discuss and formulate the chinese expert consensus. The consensus provides standardized suggestions on the principles, drug selection, administration time and methods of chrono-chemotherapy for oral squamous cell carcinoma, which can provide reference for clinical practice. References | Related Articles | Metrics

Select

2018 newly revised ISSVA classification for vascular anomalies SUN Yu-huan, CHE Zong-gang, ZHENG Jia-wei 2019, 17 (1):  13-19.  doi: 10.19438/j.cjoms.2019.01.003 Abstract ( 954 )   PDF (4248KB) ( 757 )   Vascular anomalies are a group of common congenital vascular or lymphatic lesions. The biologic classification of vascular anomalies proposed by Mulliken and Glowacki in 1982 had been widely accepted. In 1996, ISSVA developed a relatively complete classification system and the revised version approved by 2014 ISSVA General Assembly was implemented in clinical practice worldwide. In order to evolve as our understanding of the biology and genetics of vascular malformation and tumor continues to grow, the 21st ISSVA Workshop, May 2018 Amsterdam, Netherlands, expanded and updated the classification on the basis of the 2014 edition. This paper introduced the 2018 newly revised ISSVA classification of vascular anomalies for clinical, research and academic reference. References | Related Articles | Metrics

Original Articles

Select

Study on the differentially expressed long non-coding RNAs in PLAG1 transgenic mice by gene micro-array XU Wan-lin, LIU Li-min, LU Hao, YANG Wen-jun, SHEN Shu-kun 2019, 17 (1):  20-25.  doi: 10.19438/j.cjoms.2019.01.004 Abstract ( 239 )   PDF (4204KB) ( 160 )   PURPOSE: To screen for the differentially expressed long non-coding RNAs (LncRNAs) in pleomorphic adenoma of PLAG1 transgenic mice. METHODS: Three pairs of pleomorphic adenoma, non-tumor gland tissues from PLAG1 transgenic mice and normal gland tissues of submandibular gland from wide-type mice were collected and then the total RNA was extracted. cDNA probe was synthesized by reverse transcription and hybridized as the cDNA microarray for scanning fluorescent signals and differentially expressed LncRNAs. The expressions of 5 randomly selected LncRNAs were validated in another 6 pairs of tissues via real-time PCR. The expression differences were compared and analyzed using SPSS13.0 software package. RESULTS: Microarray results demonstrated that a total of 5627 LncRNAs (2871 upregulated and 2756 downregulated) were differentially expressed in the tumors of PLAG1 transgenic mice. Real-time PCR data showed that the expression of 4 selected LncRNAs (AK146794, ENSMUST00000119440, ENSMUST00000140495 and Gm12873) were consistent with the microarray results. CONCLUSIONS: Analysis of differentially expressed LncRNAs in PLAG1 transgenic mice can provide evidence for pathogenesis of pleomorphic adenoma. References | Related Articles | Metrics

Select

Hypoxia induces epithelial-to-mesenchymal transition of human tongue squamous cell carcinoma via lncRNA-HOTTIP LIN Zhi-li, LIANG Jian-ping, ZHOU Bin 2019, 17 (1):  26-31.  doi: 10.19438/j.cjoms.2019.01.005 Abstract ( 256 )   PDF (4092KB) ( 103 )   PURPOSE: To investigate the effect of lncRNA-HOTTIP on hypoxia induced epithelial-to-mesenchymal transition in human tongue squamous cell carcinoma (TSCC). METHODS: TSCC cell lines SCC9 and CAL27 were cultured under hypoxia (1% O2) or normoxia (20% O2) for 48 h. qRT-PCR was used to detect expressions of lncRNA-HOTTIP and HIF-1α at mRNA level. After transfection of HIF-1α with siRNA, HIF-1α and lncRNA-HOTTIP level were furthered detected. TSCC cell lines were further transfected lncRNA-HOTTIP with siRNA under hypoxia, the expression of HIF-1α, Vimentin, Fibronectin and E-cadherin, as well as invasion, were detected. The date was statistically analyzed with SPSS13.0 software package. RESULTS: Both SCC9 and CAL27 cells under hypoxia for 48 h showed increased lncRNA-HOTTIP and HIF-1α expression.After knocking down of HIF-1α with siRNA, lncRNA-HOTTIP level was significantly reduced. After knocking down of lncRNA-HOTTIP with siRNA, lncRNA-HOTTIP, Vimentin and Fibronectin were significantly downregulated but E-cadherin was upregulated under hypoxia; the invasion ability was decreased in SCC9 and CAL27 cells. CONCLUSIONS: Hypoxia increases HIF-1α and lncRNA-HOTTIP expression, and hypoxia induces epithelial-to-mesenchymal transition and metastasis of TSCC via upregulating lncRNA-HOTTIP. References | Related Articles | Metrics

Select

The effect of emdogain on proliferation and differentiation of co-cultured osteoblasts and endothelial cells WANG Shan-shan, Xiaohui RAUSCH-FAN, Oleh ANDRUKOV, LIN Yi, LIN Li-song, SHI Bin 2019, 17 (1):  32-39.  doi: 10.19438/j.cjoms.2019.01.006 Abstract ( 262 )   PDF (6355KB) ( 154 )   PURPOSE: To evaluate the effect of emdogain on proliferation and differentiation of osteoblasts and endothelial cells under different co-culture conditions, and to assess their correlationship. METHODS: Human umbilical vein endothelial cells (HUVECs) and osteoblast-like cells (MG63s) were directly and indirectly co-cultured in 12-well cell culture plate at a ratio of 2∶1. The cells were treated by emdogain of different concentrations (0, 0.1, 1, 10, 50 μg/mL) for 72 h. Cell proliferation was measured by cell counter in combination with flow cytometry. Direct co-cultured HUVECs and MG63s were separated by fluorescence-activated cell sorting. The expression level of alkaline phosphatase(ALP), collagen type I(Col-1), vascular endothelial growth factor (VEGF) in MG63s, and vascular endothelial growth factor receptors Flt-1 and KDR, Von Willebrand factor (vWF), endothelial cell protein C receptor (EPCR), E-selectin, and angopoietin-2(Ang-2) in HUVECs were measured by real-time quantitative polymerase chain reaction (qPCR). Statistical analysis was performed using SPSS 24 software package. RESULTS: Under direct and indirect co-culture condition, the effect of emdogain on MG63s and HUVECs proliferation was in a concentration dependent manner. The proliferation rate of cells was reduced with the increase of emdogain concentration. The inhibitory effect of emdogain on MG63s and HUVECs proliferation was the most prominent at the concentration of 50 μg/mL. The expression of ALP and Col-1 in MG63s was enhanced with the increase of emdogain concentration. The highest level of ALP and Col-1 was observed at the concentration of 50 μg/mL, and had significant difference compared with that in other groups (P<0.01). Under conditions of same emdogain concentration, the ALP and Col-1 level in directly co-cultured MG63s was significantly higher than that in indirectly co-cultured MG63s (P<0.01). Apart from the group of 10 μg/mL, VEGF level was significantly higher under direct co-culture condition than under indirect co-culture condition (P<0.01). The gene expression level of Flt-1, KDR, vWF and E-selectin in direct co-cultured HUVECs with 50 μg/mL emdogain was significantly higher than that in indirect co-cultured HUVECs with the same emdogain concentration, as well as that in other groups of direct co-culture (P<0.01). Under conditions of indirect co-culture, EPCR and Ang-2 level was significantly higher than that of direct co-culture (P<0.05). CONCLUSIONS: The effect of emdogain on proliferation and differentiation of co-cultured MG63s and HUVECs depends on its concentration, 50 μg/mL could be the key concentration. Under the condition of direct co-culture, 50 μg/mL emdogain inhibits the proliferation of MG63s and HUVECs, whereas promotes the differentiation of MG63s and HUVECs simultaneously. This effect is stronger than that under other conditions, cell-to-cell communication may play an important role. References | Related Articles | Metrics

Select

A retrospective study of risk factors for life-threatening complications of multi-space infections of head and neck HUANG Lin-jian, CHEN Jun, YAN Jun-lie, XU Xin, CAI Xie-yi 2019, 17 (1):  40-43.  doi: 10.19438/j.cjoms.2019.01.007 Abstract ( 396 )   PDF (2919KB) ( 182 )   PURPOSE: To assess the risk factors (age, gender, and underlying systemic diseases) of life-threatening complications of multi-space infections (LCMI) in the head and neck. METHODS: This was a retrospective cohort study that enrolled a sample of patients with multi-space infections who were referred from February 2006 through July 2014. The patients were classified into diabetic and nondiabetic group. Statistical analysis was performed using SPSS 19.0 software package. RESULTS: The highest incidence of LCMI was in 60-69 yr group (18.8%), which was significantly higher than 20-59 yr group (P=0.027). The correlation was further confirmed by multivariable analysis (odds ratio, 1.148; P=0.041). The odds of susceptibility for LCMI development in diabetic patients was 2.404 times as that of nondiabetic patients (odds ratio, 2.404; P=0.008). CONCLUSIONS: Aging and diabetes mellitus increase the risk of development of life-threatening complications in patients with multi-space infections of head and neck. To increase the chance of patient survival, we strongly recommended clinicians pay more attention to patients with multi-space infections, especially those over the age of 60 and/or diabetic patients. References | Related Articles | Metrics

Select

Clinical analysis of 90 cases with oral and maxillofacial space infection in Shigatse, Tibet WANG Huan, GE Sang, WU Xiao-yan, CI Dan Zha-xi, WU Dan-dan 2019, 17 (1):  44-47.  doi: 10.19438/j.cjoms.2019.01.008 Abstract ( 337 )   PDF (2756KB) ( 233 )   PURPOSE: To investigate the incidence and characteristics of oral and maxillofacial infection in patients in Shigatse, Tibet. METHODS: The data of 90 patients with oral and maxillofacial infection who were hospitalized in the Department of Stomatology of Shigatse People's Hospital from January 2015 to February 2018 were reviewed. The age of onset, occupation, pathogen, and predilection sites were analyzed. RESULTS: Among 90 patients, children, students and farmers accounted the most; odontogenic infection was the primary cause of infection, with the first and second permanent molars as the main foci. Seventy-one patients had single space infection, accounting for 78.89%; while 19 patients had multiple space infections, accounting for 21.11%; the submandibular space was involved most commonly. CONCLUSIONS: The age of onset of oral and maxillofacial space infection in Shigatse is younger. It is necessary to enhance oral health education for children and parents, improve medical and health awareness, and strengthen construction of primary medical teams. References | Related Articles | Metrics

Select

Prediction of difficult laryngoscopy using ultrasound measurement of anterior neck structure CHEN Jue-min, CAI Mei-hua 2019, 17 (1):  48-52.  doi: 10.19438/j.cjoms.2019.01.009 Abstract ( 377 )   PDF (3652KB) ( 123 )   PURPOSE: To verify the accuracy of ultrasonic measurement of the anterior neck soft tissue to predict difficult airway, to find a suitable value of the anterior neck soft tissue for Chinese population, and to compare the accuracy with other airway assessments. METHODS: One hundred and forty-one patients were included, aged 13 to 88 years old, ASA class Ⅰ-Ⅲ, undergoing endotracheal intubation for an elective surgical procedure. The name, gender, age , height, weight of each patient were recorded. The clinical screening tests to predict difficult airway were performed (BMI, interincisoral gap, modified Mallampati score, thyromental distance). Ultrasound (US) measurements of anterior neck soft tissue were obtained(the level of hyoid bone, thyrohyoid membrane, vocal cords, thyroid isthmus and suprasternal notch). The laryngoscopic view was graded using Cormack and Lehane classification by anesthesia providers on the day of surgery. The data were analyzed using SPSS 19.0 software package. RESULTS: Difficult laryngoscope (Cormack-Lehane classification III-IV) was present in 17 of 141 patients. The sonographic measurements of anterior neck soft tissue were greater in the difficult laryngoscopy group compared to the easy laryngoscopy group at the level of the thyrohyoid membrane [(2.43±0.50)cm : (2.08±0.39)cmand vocal cords [(0.98±0.21)cm : (0.87±0.20)cmand D-value (the difference between the level of the thyrohyoid membrane and the vocal cords). The cut-off value was 2.19, 1.05 and 1.19 cm, respectively. CONCLUSIONS: Sonographic measurements of anterior neck soft tissue thickness at the level of thyrohyoid membrane, vocal cords and the D-value can be used to distinguish difficult and easy laryngoscopy. References | Related Articles | Metrics

Select

Comparison of 3 kinds of mouth rinses after implant surgery XU Feng-yuan, ZHOU Lin-yi, GU Ying-xin 2019, 17 (1):  53-57.  doi: 10.19438/j.cjoms.2019.01.010 Abstract ( 1021 )   PDF (3596KB) ( 109 )   PURPOSE: To evaluate the effect of 3 kinds of mouth rinses on oral hygiene control during the wound healing period after implant surgery. METHODS: Sixty subjects were randomly divided into the experimental group (PVP-I group) and control groups (CHX group, EO group).On pre-operative and 2-week follow-up examination, mPI and mBI were evaluated. All subjects were asked to finish visual analogue scale (VAS) questionnaire about their sensation of mouth rinse. The detection of Porphyromonas gingivalis（Pg） and Fusobacterium nucleatum （Fn） in gingival fluid was conducted by real-time PCR. Statistical analysis was performed using SPSS 23.0 software package. RESULTS: Reduction in mPI was observed (P<0.05). Compared with PVP-I, EO was a stronger irritation to oral mucosa (P<0.05), CHX tended to stain on tooth (P<0.05). Drop of Fn percentage was observed in PVP-I group and CHX group. CONCLUSIONS: All 3 kinds of mouth-rinses are beneficial to oral hygiene maintenance after implant surgery. References | Related Articles | Metrics

Select

Retrospective analysis of jaw bone quality in 387 dental implants KAN Wen-jiao, FAN Bo-xi, LIU Xu, LIU Xu-zheng, SUI Jiang, SHAO Bo 2019, 17 (1):  58-61.  doi: 10.19438/j.cjoms.2019.01.011 Abstract ( 448 )   PDF (3049KB) ( 218 )   POURPOSE: To retrospectively analyze jaw bone quality in patients with dental implants in the People's Hospital of Inner Mongolia Autonomous Region from October 2015 to October 2017, in order to provide clinical reference for bone quality classification. METHODS: The age, sex, implant site, and surgical technique and bone quality classifications of 387 patients were recorded. The related data were statistically and retrospectively analyzed using Excel and SPSS 22.0 software package. RESULTS: Among 387 patients, the classification of bone mass was mainly Class Ⅱ and ClassⅢ. There was no Class IV bone. The site of implantation was mainly the posterior region. The proportion of missing teeth in the mandibular posterior region was the largest, and the proportion of Class Ⅲ bone in the maxillary posterior region was the highest. The proportion of Class Ⅱ bone in the lower anterior region was the highest. There were more female patients than male patients, and most patients were between the age of 20-60 years old, Class Ⅲ bone was mostly found in all the groups. The number of Class Ⅲ bones was the greatest among patients undergoing additional surgery. CONCLUSIONS: Different types of implant sites have different types of bone quality; age and gender may affect the bone quality of the jaws, and implants in areas with poor bone quality will lead to an increase in the proportion of additional operations. Different types of bone quality also have an impact on the failure rate of implantation. References | Related Articles | Metrics

Select

Therapeutic outcomes of using vacuum sealing drainage for oral and maxillofacial space infections in children ZHANG Zhao-tao, ZHANG Feng-he 2019, 17 (1):  62-65.  doi: 10.19438/j.cjoms.2019.01.012 Abstract ( 309 )   PDF (2791KB) ( 171 )   PURPOSE: To investigate the clinical value of vacuum sealing drainage(VSD) for oral and maxillofacial space infections in children. METHODS: Eight children less than 10 years old with oral and maxillofacial space infections were included. Their clinical data including etiology, clinical characteristics, infection progress and treatment were reviewed and analyzed. Infection index and hospitalization days of 8 children were recorded. Among them, two were treated by vacuum sealing drainage (VSD group), six were treated by traditional incision drainage (traditional group). The hospitalization day and mean WBC were compared with SPSS 17.0 software package. RESULTS: The mean WBC had no significant difference between the 2 groups before operation(P>0.05). Both indexes decreased after treatment, significant difference was found between the 2 groups(P<0.05). CONCLUSIONS: Vacuum-assisted closure therapy is useful to improve recovery of children with oral and maxillofacial space infections compared to conventional dressing. References | Related Articles | Metrics

Select

Effect of structural psychological intervention on anxiety and postoperative satisfaction of patients undergoing hyaluronic acid injection HE Min-min, CHEN Ping, HUANG Ying, BIAN Wei-wei, WANG Cao-feng 2019, 17 (1):  66-69.  doi: 10.19438/j.cjoms.2019.01.013 Abstract ( 272 )   PDF (3402KB) ( 185 )   PURPOSE: To investigate the effect of structural psychological nursing intervention on anxiety and satisfaction of microscopic plastic hyaluronic acid injection in patients undergoing cosmetic treatment. METHODS: One hundred patients with microscopic hyaluronic acid injection who were treated in our hospital from January 2017 to December 2017 were selected randomly. The patients were divided into control group and experimental group by computer, 50 patients in each group. Patients in the control group received routine care, while patients in the experimental group were given structured psychological interventions. The anxiety status and satisfaction were compared between the two groups using SPSS 21.0 software package. RESULTS: Patients in the experimental group had a stable mood after treatment, and the psychological status and patient satisfaction were better than those in the control group. The scores of SAS scale were lower than those in the control group (P<0.05). The satisfaction degree in the experimental group was significantly higher than that in the control group (P<0.01). CONCLUSIONS: Implementation of structural psychological intervention during micro-plastic hyaluronic acid injection for cosmetic patients can help to better improve their psychological status. References | Related Articles | Metrics

Clinical Reports

Select

Treatment of multiple cranionmaxillofacial trauma: experience in 20 consecutive cases GE Kui, WU Jia -jun, QIAN Li, WANG Fan-lin, FAN Jing-xian, LIANG Xiang, SHI Jun, ZHANG Shi-lei, XIE Ting, XU Bing 2019, 17 (1):  70-73.  doi: 10.19438/j.cjoms.2019.01.014 Abstract ( 272 )   PDF (3064KB) ( 221 )   PURPOSE: To discuss the treatment strategies of severe multiple craniomaxillofacial trauma. METHODS: Twenty patients (16 males and 4 females, ranged from 9 to 83 years old, with an average age of 40.8 years old) with severe multiple cranionmaxillofacial trauma treated in Emergency Intensive Care Unit (EICU) of Shanghai Ninth People's Hospital were retrospectively analyzed from Mar. 2013 to Mar. 2018. The injury situation, treatment method and outcome, including basic life support given in first-aid room, number of injury site, damage control operation, advanced life support method in EICU, the resuscitative results and the outcome, were reviewed and analyzed. RESULTS: As basic life support, 19 patients were given debridement and hemostasis, 13 patients only received liquid resuscitation, 4 patients had blood transfusion after massive liquid resuscitation, 5 patients underwent intubation /tracheotomy, 4 patients had external fixation. For the number of injury site, 3 patients had 2 injury sites, 4 patients had 3 injury sites, 7 patients had 4 injury sites, 6 patients had 5 or more injury sites. For damage control operation, 10 patients were given damage control operation, 1 patient was given orbital exploratory operation, 1 patient underwent intracranial hematoma removal and decompressed craniectomy, 1 patient had lung repair and drainage after exploratory thoracotomy and hemostasis, 1 patient had hemostasis by percutaneous intervention, 2 patients had external fixation, 4 patients' wound were repaired by covering with native pressure after debridement. For advanced life support in EICU, 6 patients were admitted directly to operate in different departments, the others 14 patients were transferred to EICU to be given advanced life support. During the time in EICU, 10 patients were given operation by different disciplines after vital signal becoming normal, 4 patients discharged and waited for plastic surgery later because missing best chance. All patients were recovered to normal condition without death. CONCLUSIONS: Multidisciplinary co-operation and continuous life support earlier are the most important strategies for severe multiple craniomaxillofacial trauma. References | Related Articles | Metrics

Select

Absolute ethanol embolization of pharyngolaryngeal venous malformation after tracheotomy under general anesthesia: a report of 20 cases LEI Shu-zan, WANG Jie -bing, ZHANG Yin-xi 2019, 17 (1):  74-76.  doi: 10.19438/j.cjoms.2019.01.015 Abstract ( 327 )   PDF (2190KB) ( 149 )   PURPOSE: To analyze the treatment method and effect of venous malformations of the pharynx and larynx. METHODS: From March 2011 to June 2015, 20 patients with pharyngolaryngeal venous malformation were treated with ethanol embolization under tracheotomy. RESULTS: Fifteen patients underwent twice absolute ethanol embolization, the lesions were remarkably shrank. Five patients developed secondary and tertiary respiratory obstruction, due to diffuse venous malformations. After absolute ethanol embolization, airway obstruction symptoms were relieved, maxillofacial blemishes faded, venous malformation lesions shrank and nearly returned to normal maxillofacial shape; 3 patients with macroglossia underwent operation after embolization, no recurrence was found after 2 years of follow-up in cases with pharyngolaryngeal venous malformations. The cure rate was 50% and effective rate was 100%. CONCLUSIONS: Ethanol embolization is an effective method for treatment of laryngopharyngeal venous malformations under tracheotomy in selected cases. References | Related Articles | Metrics

Review Articles

Select

Advances in the mechanisms of maggot debridement therapy ZHU Fang-xing, QI Lei, XU Bing 2019, 17 (1):  77-81.  doi: 10.19438/j.cjoms.2019.01.016 Abstract ( 495 )   PDF (4099KB) ( 334 )   In recent years, due to the abuse of antibiotics, maggot debridement therapy (MDT) has returned to people's eyesight. The debridement efficiency and accuracy of MDT is better than that of any surgeons. In addition, MDT has good antibacterial and healing effects. It can effectively fight resistant bacteria and promote healing of refractory wounds. In the past few decades, research on the mechanisms of MDT has not been clear enough. This article reviewed recent advances in the mechanisms of debridement, antibacterial and healing of MDT.; References | Related Articles | Metrics

Select

Demand status of family cares for postoperative patients with advanced oral cancer XU Zhu-feng, YU Xi-xi, WANG Yue-ping 2019, 17 (1):  82-85.  doi: 10.19438/j.cjoms.2019.01.017 Abstract ( 369 )   PDF (3437KB) ( 265 )   Oral cancer is a common malignant tumor in head and neck. Advanced oral cancer patients are mainly treated with surgery. Due to the lack of specialist nurses and insufficient supply of community hospitals, family cares need to take all life cares. The deficiency of knowledge and experience created a series of needs in the process of care. This article reviewed the needs of cares in order to provide reference for clinical work.; References | Related Articles | Metrics

Select

Research progress on pyroptosis and relationship between pyroptosis and tumor of head and neck ZHANG Qian-yu, HUANG Zhi-quan 2019, 17 (1):  86-92.  doi: 10.19438/j.cjoms.2019.01.018 Abstract ( 383 )   PDF (5462KB) ( 368 )   Programmed cell death refers to the way in which cells depend on certain genes to encode signals or activities. Apoptosis, autophagy, apoptosis and pyroptosis all belong to programmed cell death,pyroptosis is a programmed cell death dependent on cysteine containing aspartate proteinase (caspase) . Recently, many studies found that pyroptosis is associated with inflammatory diseases, autoimmune diseases and tumors. A thorough understanding of the mechanism of pyroptosis and its relationship with tumors is of guiding significance in the treatment of tumors. This article focus on the mechanism of pyroptosis and the related research progress of pyroptosis and tumor of head and neck. References | Related Articles | Metrics

Case Report

Select

Total lower lip reconstruction with local rotation advancement flap and Bernard-Webster flap after giant lip squamous cell carcinoma resection-a case report and literature review WANG Yao-zhong, YANG Yin-hui, GUAN Qun-li, LIN Xi-jiang 2019, 17 (1):  93-96.  doi: 10.19438/j.cjoms.2019.01.019 Abstract ( 380 )   PDF (3150KB) ( 198 )   A patient underwent total lower lip defect reconstructions after squamous cell carcinoma resection was reported. Local rotation advancement flap and Bernard-Webster flap were used to reconstruct the defect and anaplasty was performed half a year later. Based on relative literature review, the indication of different surgical techniques were compared. References | Related Articles | Metrics