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20 March 2016, Volume 14 Issue 2 Previous Issue    Next Issue

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Expression and functional role of miR-214 in oral squamous cell carcinoma WU Yue, WANG Cheng, XIE Nan, ZHUANG Ze-hang, LIU Xi-qiang, HOU Jin-song, HUANG Hong-zhang 2016, 14 (2):  97-105.  Abstract ( 439 )   HTML ( 0 )   PDF (1368KB) ( 337 )   PURPOSE: To evaluate the expression of miR-214 and investigate its functional role in oral squamous cell carcinoma (OSCC). METHODS: RT-PCR was performed to detect miR-214 expression levels in 31 OSCC tissues and 7 OSCC cell lines. The correlation of miR-214 expression with the clinicopathologic features of the patients was analyzed with Chi-square test. Then, OSCC cells were transfected with miR-214 mimics and inhibitors. Wound healing assay and Transwell assay were performed to determine cell migratory and invasive abilities. Flow cytometry was used to assess cell cycle and apoptosis. SPSS19.0 software package was used for statistical analysis. RESULTS: In 31 OSCC patients, the expression of miR-214 positively correlated with lymph node metastasis and clinical stage (P<0.05). In vitro, the invasion and migration abilities were substantially enhanced in UM1 cells (P<0.05) transfected with miR-214 mimics and decreased (P<0.05) in SCC9 cells transfected with miR-214 inhibitors. Cell cycle was arrested in G1 stage but the apoptosis was not significantly increased in UM1 cells treated with miR-214 mimics. However, there were no obvious changes on cell cycle and apoptosis in SCC9 cells treated with miR-214 inhibitors. CONCLUSIONS: miR-214 is correlated with cervical lymph node metastasis and clinical stage in OSCC. It may act as an oncomiRNA to promote invasion and migration in OSCC. References | Related Articles | Metrics

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Exosomes from adenoid cystic carcinoma cells can be uptaken by normal human salivary gland epithelial cells SONG Meng-yang, YANG Xiao-jun, HOU Jin, YIN Xue-min 2016, 14 (2):  106-110.  Abstract ( 449 )   HTML ( 1 )   PDF (1320KB) ( 464 )   PURPOSE: To detect whether human salivary gland epithelial cells (SGECs) can uptake exosomes derived from adenoid cystic carcinoma cell ACC-2. METHODS: Human normal SGECs were primarily cultured by explant out growth technique and identified by immunocytochemistry. The exosomes derived from ACC-2 were labeled with green fluorescent dye PKH67 and co-cultured with SGECs for 48h, which were then stained with Alexa Fluor 594 Phalloidin and DAPI. Afterwards, exsosomes absorption was observed under a laser scanning confocal microscope (LSCM). RESULTS: Primarily cultured normal human SGECs exhibited strong cytokeratin expression but absence of staining for α-MSA, indicating the lack of myoepithelial cells in the culture system; after 48 h of incubation, multiple green vesicles could be seen docked on SGECs and most diffuse PKH67 signals were concentrated in the cytoplasm. Moreover, the uptake of exosomes was highly efficient as all SGECs were positive for stained exosomes. CONCLUSIONS: Normal human SGECs could uptake ACC-2 derived-exosomes, indicating that SGECs might be a kind of recipient cells of ACC-2 derived- exosomes. References | Related Articles | Metrics

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miRNA-32-5p target regulating EZH2 and its effect on proliferation of human oral carcinoma cell line CAL-27 GUO Ming, HAO Wen-hui, ZHAI Xin-ying, HOU Lin-yan 2016, 14 (2):  111-116.  Abstract ( 328 )   HTML ( 0 )   PDF (1127KB) ( 404 )   PURPOSE: To construct a lentiviral vector of miR- 32-5p and verify its targeted effect on EZH2 gene and its effect on the proliferation of CAL-27 cells. METHODS: pSicoR-miR-32-5p and pMIR-Report-EZH2 over-expression vector were constructed. The targeted effect of miR-32-5p on EZH2 gene was verified by relative luciferase activity, Western blot and real-time PCR test. The effects on CAL-27 cells proliferation of over-expression miR-32-5p were analyzed by MTT assay. SPSS 20.0 software package was used for statistical analysis. RESULTS: The recombinant plasmids of pSicoR-miR- 32-5p and pMIR -Report-EZH2 3'-UTR were constructed successfully. Over-expression of miR-32-5p suppressed the mRNA and protein expression level of EZH2 significantly (P<0.05). Suppression of miR-32-5p expression increased the expression level of EZH2 mRNA and protein significantly(P<0.05).MTT assay showed that the proliferation effect of lentivirus vector of miR-32-5p on CAL-27 cells were significant(P<0.05). CONCLUSIONS: MiR-32-5p can suppress EZH2 gene expression by targeting the specific sequence of EZH2-3'UTR and affect proliferation of human oral carcinoma cell line CAL-27. References | Related Articles | Metrics

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GDF15 can be used as a potential predictive biomarker for TPF induction chemotherapy in patients with locally advanced oral squamous cell carcinoma TANG Xiao, SUN Wen-wen, ZHU Dong-wang, MA Jie, MA Hai-long, LIU Ying, TAN Yi-ran, TU Yao-yao, WANG Li-zhen, LI Jiang, ZHONG Lai-ping, ZHANG Chen-ping, ZHNAG Zhi-yuan 2016, 14 (2):  117-122.  Abstract ( 429 )   HTML ( 1 )   PDF (1148KB) ( 343 )   PURPOSE: To figure out the prognostic value of GDF15 expression in patients with locally advanced oral squamous cell carcinoma (OSCC), and to explore the clinical usefulness of GDF15 as a potential predictive biomarker for TPF (docetaxel, cisplatin and 5-fluorouracil) induction chemotherapy. METHODS: Two hundred and fifty-six patients with locally advanced OSCC from a prospective, randomized trial were enrolled into this study. Immunohistochemical staining against GDF15 was used in the biopsy specimens from these patients. Prognostic analysis was performed in these patients, especially on the relationship between GDF15 expression and TPF induction chemotherapy. SPSS18.0 software package was used for statistical analysis. RESULTS: Among the 230 patients with biopsy specimens, lower GDF15 expression was detected in 68 patients and higher GDF15 expression in 162 patients. The patients with lower GDF15 expression had a better survival than those with higher GDF15 expression, including overall survival(P=0.046), disease-free survival(P=0.0496), locoregional recurrence-free survival(P=0.065) and distant metastasis-free survival(P=0.017). Furthermore, the cN- patients with higher GDF15 expression could benefit from TPF induction chemotherapy, including overall survival(P=0.018), disease-free survival (P=0.010), locoregional recurrence-free survival (P=0.042) and distant metastasis-free survival(P=0.006). CONCLUSIONS: GDF15 expression could be used as a prognostic biomarker for patients with locally advanced OSCC. cN- patients with higher GDF15 expression could benefit from TPF induction chemotherapy. References | Related Articles | Metrics

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Application of virtual design and guide in the treatment of hemifacial microsomia WANG Min-jiao, CHEN Tian-tian, SI Jia-wen, WANG Xu-dong, SHEN Guo-fang, YU Hong-bo 2016, 14 (2):  123-127.  Abstract ( 618 )   HTML ( 1 )   PDF (1306KB) ( 401 )   PURPOSE: Accurate preoperative planning and intraoperative realization is critical to ensure successful results. This study was to explore the application of virtual design and guide in the treatment of hemifacial microsomia (HFM). METHODS: Eight patients of HFM were enrolled in this study. Virtual surgical planning, simulation and postoperative prediction were performed. Under the guidance of 3D printed guide, mandibular ramus osteotomy and distractor implant were carried out. Clinical examination was performed after removal of distractor. Surgical accuracy was evaluated by comparing the postoperative CT 3-D model with preoperative surgical planning. RESULTS: All the patients underwent virtual surgical planning, 3D guide printing and distraction osteogenesis(DO) successfully. Facial symmetry was greatly improved after treatment. The mean deviation between the preoperative design and actual surgical results was less than 2 mm. CONCLUSIONS: With the ability of preoperative planning, surgical simulation and postoperative prediction, virtual design shows great value in improving the accuracy of DO and restoring facial symmetry. It is regarded as a valuable technique in this potentially complicated procedure. References | Related Articles | Metrics

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Clinical analysis and differential diagnosis of 25 patients with IgG4-related sclerosing sialadenitis WANG Zhi-jun, ZHENG Ling-yan, PU Yi-ping, XIE Li-song, SHI Huan, YU Chuang-qi 2016, 14 (2):  128-133.  Abstract ( 732 )   HTML ( 0 )   PDF (1085KB) ( 589 )   PURPOSE: To discuss the clinical features of IgG4-related sclerosing sialadenitis and salivary glands non-neoplastic diseases presenting gland swelling, to make clear the key points of clinical differential diagnosis. METHODS: We retrospectively analyzed and compared the clinical data of IgG4-related sclerosing sialadenitis with those of salivary glands non-neoplastic diseases especially Sjögren’s syndrome (SS) in medical history, clinical examination, serology and pathology. The statistical analysis was performed using SAS 8.0 software package. RESULTS: Three hundred and thirty-five patients with salivary glands non-neoplastic diseases were included in the study, including 25 IgG4-related sclerosing sialadenitis, 279 obstructive sialadenitis and 31 SS. We compared IgG4-related sclerosing sialadenitis with the others and found out significant differences in each aspects. CONCLUSIONS: IgG4-related sclerosing sialadenitis is a kind of chronic salivary gland inflammation with glands swelling. In order to make a definite diagnosis with other salivary glands non-neoplastic diseases, a comprehensive analysis is needed. References | Related Articles | Metrics

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Clinical features of oral and maxillofacial malignant tumors in 177 Chinese children LI Si-yuan, GUO Xue-sheng, SHAN Xiao-feng, CAI Zhi-gang 2016, 14 (2):  134-139.  Abstract ( 534 )   HTML ( 1 )   PDF (829KB) ( 404 )   PURPOSE: To evaluate the composition and distribution of oral and maxillofacial malignant tumors in Chinese children. METHODS: A retrospective review of oral and maxillofacial malignant tumors of children under 18 years old, and in 2004-2013 from the records of the Department of Oral and Maxillofacial Surgery, Peking University School of Stomatology was carried out. All cases were analyzed according to site, age, gender, histological type and treatment method. RESULTS: Of all 1892 cases of tumors and tumor-like lesions in children admitted to our hospital from 2004 to 2013, 177 were malignant tumors, which constituted 9.4% of all cases. In malignant tumors, the male to female ratio was 1(n=77) to 1.3 (n=100). Their age ranged from 2 months to 17.8 years, and the median age was 10 years. The most common sites were parotid gland (28.8%), mandible (15.3%), lateral deep face (11.9%), and maxilla (10.7%). Sarcoma (46.3%) was the most common malignancy, followed by adenocarcinomas (28.8%) and malignant lymphomas (11.9%). Mucoepidermoid carcinomas, rhabdomyosarcomas, non-Hodgkin's lymphomas were the most common pathological types. Surgery dominated sequential therapy was the mainstay of treatment for sarcomas and carcinomas, while chemotherapy based comprehensive and sequential therapy was predominant treatment of malignant lymphomas. CONCLUSIONS: The composition and distribution of oral and maxillofacial malignant tumors in Chinese children are different from adults. Pathological type is an important factor which determines the therapeutic schedule of these patients. References | Related Articles | Metrics

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Oral propranolol for treatment of periorbital infantile hemangiomas XUE Lei, LIU Zi-mei, XU Da-peng, TONG Shuang, CHENG Chen, GONG He, WANG Xu-kai 2016, 14 (2):  140-143.  Abstract ( 375 )   HTML ( 0 )   PDF (853KB) ( 231 )   PURPOSE: To assess the efficacy and safety of propranolol in the management of periorbital infantile hemangiomas. METHODS: Between May 2012 and January 2014, oral propranolol was applied to 30 infants with periorbital hemangiomas at a dose of 1.0-1.5 mg/kg taken once daily. There were 10 males and 20 females aging from 2 to 13 months with a mean age of 4.8 months. The mean duration of treatment was 19 weeks (4 to 38 weeks). The first follow-up visit was performed 2 weeks after therapy and scheduled monthly thereafter. The changes of the tumor size, texture and color were monitored and recorded at a regular interval. The adverse effects after medication were observed and managed accordingly. The treatment response based on improvement in volume, color, and texture after treatment was classified using a 4-point scale system. RESULTS: All patients were followed up from 3 to 10 months. The overall response was scaleⅠ (poor) in 0 patient,scale Ⅱ(moderate) in 2 patients,scale Ⅲ (good) in 9 patients, and scale Ⅳ(excellent) in 19 patients. In all 30 infants, heart rates and blood pressure decreased 30 minutes post-medication and reached the peak within 2 hours. However, all these signs disappeared after taking propranolol for more than 12 h, and none required special treatment. Other side effects were observed in four patients involving diarrhea and one concerning sleep change. CONCLUSIONS: Oral propranolol was an effective and safe treatment for infantile periorbital hemangiomas, particularly early intervention suitable for severe periorbital proliferating infantile hemangiomas. References | Related Articles | Metrics

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Mandible resection and reconstruction with preservation of 10 mm condyle and temporomandibular joint attachment BAI Guo, YANG Chi, ZHENG Zhi-wei, FANG Yi-ming 2016, 14 (2):  144-148.  Abstract ( 544 )   HTML ( 2 )   PDF (811KB) ( 287 )   PURPOSE: To explore the effect of temporomandibular joint (TMJ) preservation surgery in the treatment for a giant mandibular ameloblastoma with healthy condylar head. METHODS: For 1 case of a giant mandibular ameloblastoma, computer-assisted technology was applied to determine the margins of the tumor and its relationship with the condylar head. Then anatomical measurements and virtual osteotomy simulation were performed based on which digital templates were made to guide intra-operative osteotomy. The condylar head was preserved and connected to the remaining ramus by costochondral graft, fixed with a reconstructive titanium plate, in order to keep the original condyle-disc relationship and a stable occlusion. The clinical effects were evaluated by intra-operative preservation of important anatomical structures, postoperative joint function, joint-jaw-occlusion relationship, as well as results of imaging follow-ups. RESULTS: Digital osteotomy templates were smoothly positioned and attached to bone surface and guided the resection of the affected region along the pre-designed margin of the ameloblastoma. The inferior alveolar nerve bundle had been well preserved; TMJ disc and normal condylar head with a height of 10 mm was also saved for mandible reconstruction with costochondral graft. Postoperative CT showed complete elimination of the ameloblastoma and its affected mandible region. The preserved condylar head and rib graft grew into each other well. One-year follow-up CT showed no recurrence of the tumor, and the patient had satisfactory functional TMJ, symmetrical facial appearance as well as stable occlusion. No facial numbness or other complications occurred. CONCLUSIONS: In the treatment of mandibular benign lesion with healthy condylar head, the concept of TMJ preservation surgery should be advocated with the facilitation of digital templates. In this way, accurate resection of the affected bone with preservation of the condylar head as well as TMJ attachments could be realized. This procedure could help maintain TMJ function and three-dimensional joint-jaw-occlusion relationship with stable post-operative outcomes. References | Related Articles | Metrics

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A preliminary study on different prognoses of oral squamous cell carcinoma treated with marginal mandibulectomy and segmental mandibulectomy QIU Yu, LIN Li-song, SHI Bin, ZHU Xiao-feng, HUANG Li, HUANG Yue, LIAO Yun-yang 2016, 14 (2):  149-153.  Abstract ( 1113 )   HTML ( 0 )   PDF (625KB) ( 457 )   PURPOSE: To compare the different prognosis between marginal mandibulectomy（MG）and segmental mandibulectomy（SG）for oral squamous cell carcinoma (OSCC) and investigate the influential factors of prognosis. METHODS: Eighty-two oral carcinoma operations involving mandibulectomy (between January 2001 and January 2015) were evaluated retrospectively. Of the 82 patients, 39 had marginal mandibulectomy,43 had segmental mandibulectomy. The local recurrent rate and survival rate of these 2 treatment modalities were analyzed by Kaplan-Meier using SPSS 19.0 software package. Cox regression model was used to determine the risk factors for recurrence. RESULTS: Three-year and 5-year local recurrent rate was 29.1% and 39.7% in MG group, and 18.4%, 34.2% respectively in SG group. The local recurrent rate between the two groups had no significant difference (P>0.05). Three-year and 5-year survival rate was 75.2%t and 55.5% in MG group, and 69.2%, 60.7% respectively in SG group. There was no significant difference between the two groups (P>0.05). Lowly differentiated pathologic type was the only influential factor for prognosis in multivariate Cox regression analysis（P=0.001）. CONCLUSIONS: Marginal mandibulectomy is a safe and effective operative in appropriate cases. For patients with lowly differentiated OSCC, close follow-up is more important for early detection of recurrence. References | Related Articles | Metrics

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Retrieval of foreign bodies in maxillary sinus via antereolateral wall of the sinus to preserve alveolar bone HU Ying-kai, YANG Chi, XU Guang-zhou, WANG Yong, ZHENG Ling-yan 2016, 14 (2):  154-157.  Abstract ( 1078 )   HTML ( 1 )   PDF (745KB) ( 298 )   PURPOSE: This study was aimed to present a functional surgery for the retrieval of displaced root fragment from the maxillary sinus to preserve the alveolar bone, and evaluate its efficiency. METHODS: Patients with foreign bodies displaced into the maxillary sinus referring to our department were collected from 2011.8 to 2014.12. The tooth of each patient, the delay between displacement and retrieval, the oroantral communication (OAC), and previous treatment procedures were recorded. After examination of orthopantomograms and computed tomograms, all patients underwent surgery to create a bone window from anterolateral wall of the maxillary sinus using piezosurgery, and repositioned with micro-plates after removal of foreign body and lesions in the sinus if the lid was large. In case the foreign body was barely detectable, endoscopy was used to help localization. The length of operating time, the duration of pain and swelling, the condition of alveolar ridge, OAC and maxillary sinus, as well as complications were assessed with clinical and imaging examinations. RESULTS: Twelve foreign bodies were extracted successfully, 4 with the help of endoscopy. Nine bone windows were repositioned while 3 others were not, the operations were completed in 20 minutes. Pain disappeared within 5.7 days on average, and swelling lasted for 14.3 days. Nasal bleeding occurred in 3 patients lasting for 0.5 to 5 days. The amount of alveolar bone loss was small and all the OACs were healed well. No patients developed complications such as facial paresthesia, facial asymmetry and infection. CONCLUSIONS: This surgery for the retrieval of displaced root fragment from the maxillary sinus is worthy of wide clinical use due to high successful rate, quick recovery, preservation of alveolar bone and minimal complications. References | Related Articles | Metrics

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Prevention of common complications after modified temporomandibular joint disc anchor ZHEN Jin-ze, ZHANG Shan-yong, YANG Chi, CHEN Min-jie, HE Dong-mei, QIU Ya-ting, ZHANG Xiao-hu, ZHENG Ji-si, SUN Shou-fu, LI Hui-ping 2016, 14 (2):  158-161.  Abstract ( 597 )   HTML ( 1 )   PDF (537KB) ( 538 )   PURPOSE: To review and analyze the common complications after modified temporomandibular joint disc anchor, and explore the causes and prevention of postoperative complication. METHODS: The patients undergoing modified anchorage surgery were followed up since July 2011 to the December 2012. They were asked to fill in the postoperative questionnaire, which included symptoms of the facial nerve injury, numbness of the operation area, manifestations of gustatory sweating syndrome, changes of appearance and function, scar, and etc. The results were statistically analyzed using SPSS 13.0 software package. RESULTS: A total of 402 patients responded to the survey, including 72 males, 330 females, and the average age was (31.36±15.18) years. The common postoperative complications of modified temporomandibular joint disc anchoring operation included eyes closing difficulty(1.09%), row lifting difficulty(6.74%), disappearance of the wrinkles on the forehead(1.28%), upper eyelid ptosis(2.91%), numbness(14.39%), gustatory sweating syndrome(1.63%), preauricular area depression(5.28%), local alopecia(0.18%), a sense of tension during opening and closing mouth(7.47%), weakness of chewing(5.10%) and etc. CONCLUSIONS: The temporomandibular joint is complicated anatomically, which makes easier for improper operation to cause a series of complications. Rich experience and higher operation skills are required for operators. References | Related Articles | Metrics

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Impact of care bundles and usual care on postoperative delirium in elderly oral cancer patients ZHANG Yan, YIN Qi, LI Yan, NI Ying, SUN Lu-lu, GUO Yong 2016, 14 (2):  162-166.  Abstract ( 322 )   HTML ( 0 )   PDF (688KB) ( 447 )   PURPOSE: To investigate the impact of care bundles against risk factors on postoperative delirium in elderly oral cancer patients. METHODS: One hundred and sixty elderly oral cancer patients who were planned to undergo tumor resection surgery were selected, and subsequently randomly divided into 2 groups: group R and group I. During the perioperative period, group R received regular guidance and care, while group I was given care bundles based on regular care, which was aimed at the risk factors of postoperative delirium. Care bundles comprised of several special individualized care measures such as nursing education, psychological care, cognitive stimulation, early activity, maintaining the sleep-wake cycle and etc. At the same time, RASS, CAM-ICU, VAS scale and QoR40 scores were dynamically monitored. All statistical analysis was performed by using SPSS16.0 software package. RESULTS: There was no significant difference between the 2 groups in general characteristics. RASS scores and QoR40 scares during the three postoperative days in group I were better than group R; moreover, the incidences and duration of postoperative delirium in group I were less than group R. No significant difference was seen in VAS scores between the 2 groups. CONCLUSIONS: Care bundles against risk factors on postoperative delirium in elderly oral cancer patients could ameliorate RASS scores and decrease postoperative delirium. References | Related Articles | Metrics

Clinical Reports

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Use of extended vertical lower trapezius island myocutaneous flaps to cover exposed reconstructive mandibular plates WANG You-yuan, ZHANG Da-ming, ZHONG Jiang-long, FAN Song, LIN Zhao-yu, FANG Si-lian, CHEN Wei-liang 2016, 14 (2):  167-171.  Abstract ( 528 )   HTML ( 1 )   PDF (1279KB) ( 360 )   PURPOSE: Plate exposure was the most common complication following reconstruction after oncological resection using a titanium plate, we evaluated the outcomes of covering exposed reconstructive mandibular plates with extended vertical lower trapezius island myocutaneous flaps (TIMFs) in the present study. METHODS: Twelve patients with exposure of reconstructive plates were treated following segmental mandibulectomy due to cancer of the oral cavity and oropharynx. We covered the plates with extended vertical lower TIMFs. The primary site of tumor was located in gingiva/mandible in 5 cases, buccal mucosa in 3 cases, the floor of the mouth in 2 cases, and the base of the tongue in 2 cases. The types of bone defect were hemi-mandible in 1 case, central defect in 2 cases, and lateral defect in 9 cases. Intraoral, extraoral, and intra-extraoral exposure occurred in 1, 7 and 4 cases, respectively. Intraorally and extraorally exposed plates were re-covered with skin paddles measuring 6 cm×7 cm to 6 cm×23 cm (average, 6.0 cm×13.5 cm). Four folded extended vertical lower TIMFs were used to cover the plates exhibiting intra-extraoral exposure. RESULTS: All flaps survived. Patients were followed-up for 12-36 months (mean time 22.8 months). One patient (8.3%) exhibited external plate exposure at 20 months. Nine patients (75.0%) were alive with no evidence of disease at 12-36 months and two (16.7%) were alive with disease at 20-28 months. One patient (8.3%) died of local recurrence at 23 months. CONCLUSIONS: The use of extended vertical lower TIMFs to cover intraorally, extraorally, or intra-extraorally exposed plates is reliable. References | Related Articles | Metrics

Dental Education

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Oral and maxillofacial surgery in China: review and prospective LIU Xiao-han, ZHENG Jia-wei, YANG Chi 2016, 14 (2):  172-178.  Abstract ( 461 )   HTML ( 5 )   PDF (1101KB) ( 488 )   This article introduced the developing history, present status and future perspective of oral and maxillofacial surgery specialty in China, with the aim to provide references for Chinese oral and maxillofacial surgery education and further development. References | Related Articles | Metrics

Review

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Advances in application of TMJ disc anchoring operation SUN Shou-fu, ZHANG Shan-yong, YANG Chi 2016, 14 (2):  179-182.  Abstract ( 1100 )   HTML ( 22 )   PDF (519KB) ( 1189 )   Opening anchoring operation is one of the surgical methods for treatment of TMJ disc displacement. It was not until 2001 when Professor Larry Wolford first proposed the articular disc anchoring operation, that this method had been gradually recognized by international colleagues. During recent years, it was improved continuously and has become more perfect. But due to the complex local anatomical structure, it is difficult for beginners to master. This article discussed the indication, operation development and curative effect of TMJ opening anchoring operation. References | Related Articles | Metrics

Case Reports

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Efficacy of treatment of mandibular cyst by using the concentrated growth factors: report of 2 cases SU Ming-yang, LIN-xuan, WU Xi-feng, XU Duo-ling, LI Yang, LI bo-you, GAO Yong-bo 2016, 14 (2):  183-188.  Abstract ( 366 )   HTML ( 0 )   PDF (1030KB) ( 483 )   Jaw cyst, a common disease, often results in varying degrees of jaw bone defects. Concentrated growth factors (CGF) can promote bone tissue healing and shorten the healing period. This article reported the clinical efficacy of regeneration of bone defects after maxillary cyst surgery by using concentrated growth factors in 2 cases. References | Related Articles | Metrics

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Resection of synovial chondrosarcoma of temporomandibular joint involving the skull base with simultaneous reconstruction: report of one case YE Zhou-xi, YANG Chi, CHEN Min-jie, HUANG Dong 2016, 14 (2):  189-192.  Abstract ( 507 )   HTML ( 0 )   PDF (2078KB) ( 379 )   Synovial chondrosarcoma (SCS) is a rare malignant cartilaginous tumor that arises from synovial chondromatosis (SCM) or de novo. To our knowledge, only three previously studies reported its involvement of temporomandibular joint (TMJ). Here, we present a case of a 56-year old woman with a SCS of TMJ involving the infratemporal space and the skull base. The lesion was resected with the aid of the digital template, while the skull base and the condyle were immediately reconstructed with ilium bone flap (IBF) and pedicled sternoclavicular joint (SCJ). There was no clinical or imaging sign of local recurrence and bone metastasis during 1-year follow-up period, but metastasis to lung was observed. References | Related Articles | Metrics