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Expert consensus on diagnosis and clinical management of medication-related osteonecrosis of the jaw HE Yue, CHEN Heng, AN Jin-gang, GUO Yu-xing, PAN Jian, TIAN Lei, LIU Bing, HOU Jin-song, LI Jin-song, JIANG Can-hua, LI Meng-yu, TIAN Zhen, XU Jie, ZHU Ling, SUN Chang-fu, ZHI Ke-qian, QU Qing, ZONG Chun-lin, SUN Jing-jing, ZHANG Zhi-yuan China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 313-325.   DOI: 10.19438/j.cjoms.2023.04.001 Abstract （546）      PDF （2051KB）（759）       Knowledge map    Medication-related osteonecrosis of the jaw(MRONJ) is a complication caused by the application of anti-resorptive medications, angiogenesis inhibitors, hormones and other medications for the treatment of some systemic diseases. The clinical symptoms include swelling, pain, masticatory disorders, persistent fistula, bone exposure and even pathological fracture, which seriously affect the patients' quality of life. Domestically, there is a lack of consensus or guidelines on classification, staging and treatment of MRONJ, and different institutions make diagnosis and treatment plans empirically. In order to unify and standardize the diagnosis and treatment of MRONJ and improve the prognosis, an expert panel of MRONJ research from 12 famous domestic medical colleges and affiliated hospitals convened a meeting to discuss the diagnosis and treatment opinions of MRONJ. Meanwhile, consensus recommendations were also revised with a comprehensive literature review of the previous treatment experiences and research findings. Finally, this expert consensus was finished for clinical references. Reference | Related Articles | Metrics

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The expression and biological functions of sphingosine-1-phosphate receptor 4 in oral squamous cell carcinoma ZHOU Xin-xia, LIU Jing-hao, GAN Gui-fang, CHEN Fu-xiang China Journal of Oral and Maxillofacial Surgery    2024, 22 (1): 10-15.   DOI: 10.19438/j.cjoms.2024.01.002 Abstract （62）      PDF （1203KB）（142）       Knowledge map    PURPOSE: To explore the expression and biological functions of sphingosine-1-phosphate receptor 4 (S1PR4) in oral squamous cell carcinoma (OSCC). METHODS: The expression of S1PR4 in OSCC tissue samples and cell lines (WSU-HN4, WSU-HN6, CAL27, WSU-HN30) was analyzed by RT-qPCR, Western blot and IHC. The activity of S1PR4 was inhibited by S1PR4 antagonist(CYM50358), and the effect of CYM50358 on proliferation of OSCC cells was detected by CCK-8 and clonal formation assay. The effect of CYM500358 on apoptosis of OSCC cells was evaluated by flow cytometry. SPSS 23.0 software package was used for statistical analysis. RESULTS: The transcription and expression of S1PR4 were up-regulated in OSCC. The activity of proliferation and clonality were decreased(P<0.05), while the percentage of apoptotic cells was increased in CYM50358-treated OSCC cells(P<0.05). CONCLUSIONS: The expression of S1PR4 is up-regulated in OSCC. S1PR4 antagonist can significantly reduce viability and promote apoptosis of OSCC cells, and may be a potential indicator for treatment of OSCC. Reference | Related Articles | Metrics

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Expert consensus on surgical treatment of hemangiomas and vascular malformations in the head and neck WANG Yan-an, QIN Zhong-ping, ZHENG Jia-wei, LI Chun-jie, LIU Shao-hua, YANG Yao-wu, CHEN Gang, CHEN Wei-liang, LIU Xue-jian, DU Zhong, ZHANG Lei, WANG Ye-fei, WANG De-ming, SU Li-xin, XIE Feng, DONG Chang-xian, GUO Lei, LI Kai, GU Song, HE Yue, ZHANG Zhi-yuan China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 105-117.   DOI: 10.19438/j.cjoms.2024.02.001 Abstract （62）      PDF （2515KB）（78）       Knowledge map    Hemangiomas and vascular malformations are common benign vascular diseases in the head and neck region. The evolution and extensive implementation of non-surgical therapeutic modalities have resulted in considerable improvement or even total remission in a significant number of patients in minimally invasive or non-invasive procedures. Nonetheless, under certain circumstances, surgical treatment remains an irreplaceable treatment modality within the comprehensive treatment sequence for hemangiomas and vascular malformations in the head and neck. However, there is no established standard or consensus in the academic community on how to choose and apply surgical treatment. Therefore, to enhance the treatment efficacy of hemangiomas and vascular malformations amongst domestic peers, and to standardize surgical treatment protocols, this consensus brings together the discussion opinions of relevant experts from many medical schools and affiliated hospitals nationwide. Based on the latest domestic and international research results and diagnosis and treatment experience, we formulated this expert consensus from the aspects of preoperative diagnosis and preparation, surgical treatment indications and strategies, postoperative care and observation, common complications and treatment after surgery, follow-up and social psychological support. It is expected to be used in clinical practice and to guide relevant professional doctors carrying out treatment. Reference | Related Articles | Metrics

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Chinese experts consensus on the use of oral propranolol for treatment of infantile hemangiomas(version 2022) ZHENG Jia-wei, WANG Xu-kai, QIN Zhong-ping, FAN Xin-dong, LI Kai, YANG Yao-wu, HUO Ran, LIU Shao-hua, ZHAO Ji-hong, WANG Xiao-yong, ZHOU De-kai, LIU Xue-jian China Journal of Oral and Maxillofacial Surgery    2022, 20 (4): 313-319.   DOI: 10.19438/j.cjoms.2022.04.001 Abstract （806）      PDF （1061KB）（654）       Knowledge map    Since 2008, propranolol has become the first-line treatment for infantile hemangiomas. Many researches have been reported on its treatment mechanism both at home and abroad, and several expert consensus or clinical practice guidelines have been formulated and published. In recent years, with the continuous accumulation of clinical experience, increasing number of basic research works, and deepening understanding of the pathogenesis of hemangioma and the mechanism of action of propranolol, it is necessary to update the expert consensus to be more consistent with clinical practice, in order to guide medication and management, provide scientific norms for the clinical use of propranolol in the treatment of infantile hemangiomas. This updated version mainly simplified the process of clinical examination, medication, and monitoring, making it more convenient and operable. Reference | Related Articles | Metrics

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Clinical application of Tent-Peg technique in the reparation and regeneration of alveolar bone-standard operational practice ZOU Duo-hong, LIU Chang-kui, XUE Yang, HU Kai-jin, YANG Chi, ZHNAG Zhi-yuan China Journal of Oral and Maxillofacial Surgery    2021, 19 (1): 1-5.   DOI: 10.19438/j.cjoms.2021.01.001 Abstract （2026）      PDF （3998KB）（1351）       Knowledge map    ] Alveolar bone is the foundation of dentology. The reparation and regeneration of alveolar bone defects have strong relationship with sub-disciplines including implant dentistry, orthodontics, periodontology and prosthodontics. Therefore, the effective methods of repairing and reconstructing alveolar bone have important clinical significance and great social benefits. With the development of guide bone regeneration (GBR) technique and advent of alveolar bone regeneration based on stability centered concept, an entirely new bone augmentation approach based on Tent-Peg technique developed rapidly and was validated in clinical practices. The technique is characterized by low technique sensitivity, simple operation procedure, short operation time and low costs. Furthermore, alveolar bone regeneration based on this technique can be achieved with just artificial biomaterials instead of autogenous bone grafts. In conjunction with its advantages, Tent-Peg technique is increasingly favored and valued by patients and clinicians. However, clinicians still face many difficulties achieving effectively clinical application of this technique, including standard operation practice, right position of the Tent-Peg, proper orientation of the pegs and right order of placing GBR membrane and Tent-Peg. Our team established standard operation practice of Tent-Peg technique for alveolar bone regeneration based on clinical practice. We hope that this article will provide a reference and basis for clinicians when applying this technique for alveolar bone regeneration, popularize the clinical application of this technique and finally offer practical help to patients suffering from alveolar bone defects. Reference | Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2013, 11 (1): 39-43.   Abstract （281）      PDF （904KB）（510）       Knowledge map    Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2007, 5 (2): 83-90.   Abstract （1935）      PDF （1354KB）（3951）       Knowledge map    Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2017, 15 (2): 185-188.   DOI: 10.19438/j.cjoms.2017.02.018 Abstract （355）      PDF （2529KB）（921）       Knowledge map    Reference | Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2009, 7 (2): 168-175.   Abstract （505）      PDF （1607KB）（1711）       Knowledge map    Related Articles | Metrics

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Risk factors for obstructive sleep apnea in snoring adults ZHENG Tong, YAO Kan, QIAN Yi-feng, SUN Hong-xia, LU Xiao-feng, YU Wen-wen China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 137-142.   DOI: 10.19438/j.cjoms.2024.02.004 Abstract （38）      PDF （757KB）（41）       Knowledge map    PURPOSE: To explore the risk factors for obstructive sleep apnea in snoring adults. METHODS: A cross-sectional study was conducted in 1 155 adult snoring patients who were overnight polysomnography(PSG) monitored for obstructive sleep apnea(OSA) from January 2012 to October 2021 in Sleep Medicine Center of Shanghai Ninth People's Hospital. The patients were divided into two groups based on apnea hypopnea index (AHI): non-OSA and OSA groups. The prevalence and risk factors of OSA were analyzed. RESULTS: The prevalence of OSA was 88.23%, and the male to female ratio was 4.12∶1. The risk factors for OSA in snoring adults were age, neck circumference/height ratio, gender and waist circumference, of which the thresholds were 30.5 years old, 22.93, male, 86.25 cm. WRAG-N was proposed to predict OSA, with an AUC of 0.789, a sensitivity of 87.2%, and a specificity of 29.4%. CONCLUSIONS: For adult snoring population, the risk factors for OSA were over 30 years old, male and waist circumference greater than 86.25 cm. Meanwhile, neck circumference/height ratio is one of the key risk factors for OSA. WRAG-N, innovatively proposed as the predictive tool for OSA, may help communities screen OSA in high-risk snoring adults to provide efficient and high-quality diagnosis and treatment. Reference | Related Articles | Metrics

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Comparison of forearm flap and anterolateral thigh flap in reconstruction of oral and maxillofacial defects ZHANG Jie, MENG Jian, ZHUANG Qian-wei, WU Rui-han, WANG Xing China Journal of Oral and Maxillofacial Surgery    2017, 15 (1): 59-62.   DOI: 10.19438/j.cjoms.2017.01.013 Abstract （476）            Knowledge map    PURPOSE: To compare and analyze the clinical effectiveness of forearm flap and anterolateral thigh flap in reconstruction of oral and maxillofacial defects. METHODS: Fifty-four cases undergoing oral and maxillofacial defect reconstruction with forearm flap and anterolateral thigh flap were reviewed. Thirty-three cases used forearm flap (group A), and 21 cases used anterolateral thigh flap after tumor resection. Operative duration, survival rate of flap, shape changes of recipient site, donor site and patients' satisfaction were analyzed between 2 groups with SPSS 19.0 software package. RESULTS: The operative duration of group A was （41.6±8.9） min, （47.2±10.2） min in group B, and the difference was statistically significant (P<0.05). Flap survival rate was 93.9% in group A and 90.5% in group B, the difference was not statistically significant (P>0.05). Shape changes of recipient site in group A were similar to group B. Donor site recovery was better in group B. The rate of permanent dysfunction in group A was 24.2% and 0 in group B, and the rate of temporal dysfunction was 9.5% in group B. CONCLUSIONS: Forearm flap was as useful as anterolateral thigh flap in reconstruction of postoperative defects of oral and maxillofacial tumors. In clinical practice, advantages and disadvantages should be considered according to individual conditions in selection of free flaps. Reference | Related Articles | Metrics

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Research progress of adoptive T cell therapy in head and neck squamous cell carcinoma CHEN Yin-yu, CHEN Lin, XU Feng, ZOU Zi-chuan, GE Liang-yu, MENG Jian China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 192-197.   DOI: 10.19438/j.cjoms.2024.02.014 Abstract （31）      PDF （585KB）（37）       Knowledge map    Adoptive T cell therapy(ACT) is a new adoptive cell immunotherapy, which is developing rapidly in clinical research. Several studies have shown that ACT could enhance the specificity and reactivity of tumor tissue by increasing the number of T cells, thereby overcoming the suppression of tumor immune deficiency. There are three main modes of ACT: tumor infiltrating lymphocytes(TILs), chimeric antigen receptor T cells(CAR-T), and T cell receptor engineered T cells(TCR-T). In this review, we discussed the classification and research progress of various ACT therapies, including TILs, TCR-T, CAR-T and adoptive T cell therapy based on organoid co-culture, and explored the application prospects of ACT as a treatment method for head and neck squamous cell carcinoma. Reference | Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2006, 4 (6): 427-429.   Abstract （497）      PDF （632KB）（474）       Knowledge map    Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2006, 4 (2): 113-116.   Abstract （999）      PDF （295KB）（328）       Knowledge map    Related Articles | Metrics

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Research progress of the machanism of ossification in maxillary sinus after maxillary sinus floor elevation GUAN Xiang-yu, GAO Yi-ming China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 198-201.   DOI: 10.19438/j.cjoms.2024.02.015 Abstract （27）      PDF （448KB）（34）       Knowledge map    In posterior maxillary area, due to progressive bone resorption and the limitation of anatomic location of maxillary sinus after tooth loss, routine implant surgery was restricted. Maxillary sinus floor elevation is the main mean to solve the problems. In this paper,the mechanism of ossification in the maxillary sinus and its influential factory, and problems which need to be further studied were summarized. Reference | Related Articles | Metrics

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Expert consensus on clinical diagnosis and treatment for Chinese oral mucosal melanoma GUO Wei, REN Guo-xin, SUN Mo-yi, KONG Yun-yi, WANG Li-zhen, BU Rong-fa, RAN Wei, TANG Zhan-gui, LI Long-jiang, MENG Jian, SUN Zhi-jun, SHANG Wei, LV Jiong, WU He-ming, ZHANG Chen-ping, HE Yue, MA Xu-hui, SONG Hao, JU Hou-yu, ZHENG Jia-wei, GONG Zhong-cheng, YANG Kai, ZHANG Jie, WU Yun-teng China Journal of Oral and Maxillofacial Surgery    2021, 19 (6): 481-488.   DOI: 10.19438/j.cjoms.2021.06.001 Abstract （508）      PDF （1408KB）（508）       Knowledge map    [Summary] Head and neck mucosal melanoma (HNMM) is a kind of highly malignant solid tumor. The 5-year survival rate of HNMM is about 20% for a long time. Its pathogenic factors, driving genes, clinical manifestations and treatment methods are quite different from skin melanoma. In 2015, the first Chinese expert consensus on the diagnosis and treatment of head and neck mucosal malignant melanoma was established. After more than six years of application, the clinical diagnosis and treatment of HNMM has been greatly improved. With the deepening of clinical and basic research on mucosal melanoma, the diagnosis, treatment and prognosis of HNMM have changed greatly in recent years, especially with the vigorous development of various branches of head and neck. Oral, nasal, sinus, eye and other mucosal melanoma have developed their own unique diagnosis and treatment model. This consensus can’t meet the actual needs of the current clinical practice. In this regard, the expert group believes that head and neck mucosa contains a wide range of anatomy, involving more clinical departments, and the diagnosis and treatment mode of melanoma varies significantly between different disciplines. It is urgent to meet the clinical consensus of more specialized diagnosis and treatment of individualized treatment and precise treatment. In order to further improve the long-term survival rate and quality of life of oral mucosal melanoma (OMM) and make the consensus to better guide clinical work, this expert group will focus on OMM and conduct in-depth discussion, and establish expert consensus based on evidence-based medicine and empirical medicine. Considering the individual differences of patients, this consensus can be used as a reference for clinical practice of OMM. Reference | Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2013, 11 (3): 238-242.   Abstract （276）      PDF （2479KB）（421）       Knowledge map    Related Articles | Metrics

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Recent advances in mouth breathing diagnosis and effects on dento-maxillofacial development in children ZHENG Yang-shan, YUAN Xue-shun, JIANG Jing, QIU Shu-qi, SHI Zhao-hui China Journal of Oral and Maxillofacial Surgery    2024, 22 (1): 92-101.   DOI: 10.19438/j.cjoms.2024.01.016 Abstract （64）      PDF （1261KB）（72）       Knowledge map    Upper airway obstruction can lead to mouth breathing, which is much prevalent in children. Studies have indicated that in early childhood, prolonged mouth breathing leads to muscular and postural alterations which, in turn, result in dentoskeletal changes, or even worse, dentofacial deformities and sleep-related breathing disorders. A multidisciplinary team, involving otolaryngologists, dental providers, and somnologists, should work to provide early diagnosis and appropriate treatment, preventing the consequent disorders of mouth breathing. More and more studies in recent years have focused on mouth breathing diagnosis and its effects on dento-maxillofacial development as well as its possible mechanisms in children. Nevertheless, the etiology, diagnosis, treatment options, postoperative care, mechanism of mouth breathing impact on dento-maxillofacial development, and its relationship with sleep-disordered breathing remain controversial. This review summarized the latest advances in mouth breathing, demonstrating the current status and advances of research on mouth breathing diagnosis, dento-maxillofacial development, and multidisciplinary collaboration. Reference | Related Articles | Metrics

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Familial gigantiform cementoma: analysis of a large Chinese pedigree WANG Hong-wei, YU Miao, QIN Xing-jun, WANG Li-zhen, XU Li-qun, ZHANG Chen-ping China Journal of Oral and Maxillofacial Surgery    2014, 12 (4): 360-364.   Abstract （456）   HTML （2）    PDF （1571KB）（1041）       Knowledge map    PURPOSE: Familial gigantiform cementoma (FGC) is a rare autosomal dominant benign odontogenic tumor. The purpose of this study is to describe the clinical characteristics of FGC in a Chinese family with multiple-affected members. METHODS: Detail screening was conducted on family members of a 13-year-old Chinese male with recent diagnosis of FGC. All family members of the patient were interviewed. Demographic, past medical and surgical histories were collected from family members with history of FGC diagnosis. Clinical information related to the lesions (symptom, age of onset, history of treatment, histological and radiological findings) was obtained. Literature review was also presented in this study. RESULTS: In this study, we found a four-generation Han Chinese family with thirteen affected members with diagnosis of FGC. Eight male patients and five female patients were appreciated in the study. All 13 patients experienced the onset of symptoms at 11-13 years old followed by a rapid and expansive growth phrase at the age of 14-16, and growth suppression phase around age 18 to 20 years old. Eight patients in our series had sustained multiple pathological long bone fractures (average 3-4 x/person) between the age of 13 and 16 years. CONCLUSIONS: The familial history of this case helps to demonstrate that the inheritance pattern of FGC was autosomal dominant. FGC usually presented with three distinctive growth phrases: ①Initial onset; ②Rapid expansion; ③Growth suppression phase. Reference | Related Articles | Metrics

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Risk factors for complications and ICU care of 144 cases with oral and maxillofacial space infection ZHANG Yin-yin, ZHU Yan-yan, DING Jia-hui, SUN Yu-hua China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 148-152.   DOI: 10.19438/j.cjoms.2024.02.006 Abstract （36）      PDF （544KB）（31）       Knowledge map    PURPOSE: To analyze the related risk factors of complications and intensive care unit(ICU) monitoring in patients hospitalized for oral and maxillofacial space infection(OMSI). METHODS: A total of 144 patients with OMSI admitted to the Affiliated Hospital of Xuzhou Medical University from January 2021 to March 2022 were selected. The patient's age, gender, length of hospital stay, systemic diseases, body mass index(BMI), source of infection and number of involved sites, complications, and laboratory indicators including white blood cell count(WBC), neutrophil percentage (NEU%), C-reactive protein (CRP) were collected. SPSS 25.0 software package was used for data analysis. RESULTS: Among 144 patients with OMSI, 52 cases (36.1%) had complications, of which 34.6% had symptoms of airway obstruction; 54 cases (37.5%) were transferred to ICU. Multivariate logistic regression analysis showed that high CRP value (OR=1.005, 95%CI: 1.000-1.011, P=0.048) were risk factors for patients with possible complications. Complications(OR=5.249, 95% CI: 1.644-16.754, P=0.005), hospital stay longer than 10 days (OR=1.166, 95%CI: 1.049-1.295, P=0.004), more space involvement(OR=2.719, 95%CI: 1.658-4.460, P<0.001), and high BMI (OR=1.262, 95%CI: 1.050-1.515, P=0.013) were independent risk factors affecting ICU monitoring. CONCLUSIONS: High CRP and BMI values and the number of infected spaces are closely related to the complications of patients and ICU monitoring. Therefore, it is necessary to strengthen the management of such patients and take comprehensive consideration in the treatment process to avoid the occurrence of adverse prognosis. Reference | Related Articles | Metrics