Comparison among dexmedetomidine, propofol and midazolam for sedation in patients with intubation after oral and maxillofacial surgery

doi:10.19438/j.cjoms.2020.01.010

Abstract

Abstract: PURPOSE: Due to adjacent to the airway, oral and maxillofacial surgery is more common and serious to have emergency airway than other surgeries. The aim of this study was to clarify the beneficial sedative effects for patients with postoperative intubation in the intensive care unit (ICU) after oral and maxillofacial surgery. METHODS: Sixty patients with postoperative intubation were divided into 3 groups using random number table: midazolam group, propofol group and dexmedetomidine group. Ramsay score, behavioral pain scale(BPS) score, SpO₂, HR, MAP, and RR were recorded before sedation, 30 min(T₁), 1 h(T₂), 2 h(T₃), 6 h(T₄), and 12 h(T₅) after sedatives initiation in ICU, and 10 min after extubation (T6). The rate of incidences of side effects was calculated. The data were analyzed with SPSS 19.0 software package. RESULTS: Midazolam, dexmedetomidine and propofol had similar sedative effect. BPS score in dexmedetomidine group was significantly lower than that in propofol group and midazolam group at time point of T₃, T₄ and T₅ (P<0.05). The incidence of bradycardia in dexmedetomidine group was significantly higher than that in midazolam group and propofol group (P<0.05). There was no significant difference in the incidence of hypotension among 3 groups (P>0.05). The number of restlessness in dexmedetomidine group and propofol group was significantly lower than that in midazolam group(P<0.05). CONCLUSIONS: Dexmedetomidine and midazolam can meet the needs for sedation in ICU patients. Dexmedetomidine can improve patients' ability to communicate pain compared with midazolam.

Key words: Dexmedetomidine, Midazolam, Propofol, Sedation, Analgesic

CLC Number:

R782.05

WANG Li, ZHANG Tie-jun, PENG Wei. Comparison among dexmedetomidine, propofol and midazolam for sedation in patients with intubation after oral and maxillofacial surgery[J]. China Journal of Oral and Maxillofacial Surgery, 2020, 18(1): 51-55.

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