China Journal of Oral and Maxillofacial Surgery ›› 2022, Vol. 20 ›› Issue (4): 390-395.doi: 10.19438/j.cjoms.2022.04.013

• Original Articles • Previous Articles     Next Articles

Expression and clinical significance of chemerin in oral squamous cell carcinoma patients combined with type 2 diabetes

YANG Song1,2, WANG Ning3, ZHAO Shu-chao4, LI Heng-yong1,2, GE Sheng-you1,2, ZHOU Kai1,2, SONG Kai1,2, SHANG Wei1,2, FENG Yuan-yong1,2   

  1. 1. Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Qingdao University. Qingdao 266003;
    2. College of Stomatology,
    3. Department of Pathology, School of Basic Medicine, Qingdao University. Qingdao 266003;
    4. Department of Pathology, Affiliated Hospital of Qingdao University. Qingdao 266003, Shandong Province, China
  • Received:2022-01-09 Revised:2022-04-19 Online:2022-07-20 Published:2022-08-02

Abstract: PURPOSE: To explore the expression and clinical significance of chemerin in oral squamous cell carcinoma (OSCC) patients with type 2 diabetes (T2DM), analyze the relationship with clinicopathological characteristics and prognosis, in order to provide evidence for further postoperative treatment of OSCC patients with T2DM (T2DM-OSCC). METHODS: OSCC specimens combined with type 2 diabetes and without type 2 diabetes (general OSCC) were selected from the Department of Oral and Maxillofacial Surgery of the Affiliated Hospital of Qingdao University from January 2009 to December 2014. Chemerin expression levels in tumors and para-cancerous tissues were detected by immunohistochemistry (IHC), SPSS 26.0 software package was used for data analysis. RESULTS: In the T2DM-OSCC patients, chemerin expression was significantly higher in tumor tissues compared with para-cancerous tissues (P<0.05) and chemerin expression was associated with cervical lymph node metastasis, higher TNM stage, lower tumor differentiation, and tumor recurrence (P<0.05). Chemerin expression in tumor tissues of T2DM-OSCC patients was significantly higher than that in ordinary OSCC patients (P<0.05). Log-Rank analysis and Kaplan-Meier analysis showed that the 5-year OS was shorter in the group of high chemerin expression combined with type 2 diabetes than other three groups(P<0.05). Cox model showed that chemerin expression in tumor tissues was an independent prognostic factor (P<0.05) affecting OS of T2DM-OSCC patients. CONCLUSIONS: Chemerin expression was higher in T2DM-OSCC patients than in ordinary OSCC, high expression of chemerin suggests poor prognosis in T2DM-OSCC patients. Chemerin is expected to be a potential indicator and target molecule for judging the prognosis of T2DM-OSCC patients.

Key words: Chemerin, Oral squamous cell carcinoma, Type 2 diabetes, T2DM, Prognosis

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