China Journal of Oral and Maxillofacial Surgery ›› 2022, Vol. 20 ›› Issue (3): 235-238.doi: 10.19438/j.cjoms.2022.03.005

• Original Articles • Previous Articles     Next Articles

Comparison of the effect of two kinds of biopsy on prognosis of oral mucosal malignant melanoma - a retrospective analysis of156cases

HAN Ru-xue1,2, MA Xu-hui1, LI Zhi1,2, REN Guo-xin1, GUO-Wei1, WU Yun-teng1, LIANG Xiang3   

  1. 1. Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology. Shanghai 200011;
    2. School of Stomatology, Weifang Medical College. Weifang 261021, Shandong Province;
    3. Department of Thoracic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China
  • Received:2021-10-18 Revised:2022-01-14 Online:2022-05-20 Published:2022-05-20

Abstract: PURPOSE: To compare the effect of two kinds of biopsy on prognosis of oral mucosal malignant melanoma (OMM), in order to find an optional biopsy method for OMM. METHODS: Patients with OMM treated at Shanghai Ninth Hospital, Shanghai Jiao Tong University School of Medicine from Jan.2010 to Jan.2018 were retrospectively analyzed. Correlation between biopsy methods and prognosis were explored. Overall survival (OS) was the primary outcome, and OS was the time from pathological diagnosis to the date of death or follow-up (September 1, 2021). SAS 9.3 software was used for statistical analysis. RESULTS: Univariate analysis showed that T stage, cervical lymph node(CLN) status, biopsy type and OS were statistically correlated. All the three variables were included in Cox regression model for multivariate analysis. The results showed that T stage, CLN and biopsy type were independent prognostic factors of OS(P<0.05). CLN and biopsy methods were identified as prognostic factors. Incidences of CLN and distant metastasis were both significantly less in cryogenic biopsy group than in incisional biopsy group (53% vs. 74% and 22% vs. 42%, Log-rank=12.955, P<0.01 respectively). The 3- and 5-year OS was significantly longer in cryogenic biopsy group than in incisional biopsy group (65% vs. 42%,Log-rank=12.570, P<0.01 and 54% vs. 20%, Log-rank=7.203, P<0.01, respectively). CONCLUSIONS: The 3- and 5- year OS in cryogenic biopsy group was significantly better than that in the incisional biopsy group. Cryogenic biopsy could significantly reduce CLN and distant metastasis of OMM. Therefore, Use of cryogenic biopsy instead of incisional biopsy to clarify the diagnosis of OMM is recommended.

Key words: Oral cavity, Mucosal malignant melanoma, Cryotherapy, Incisional biopsy

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