China Journal of Oral and Maxillofacial Surgery ›› 2021, Vol. 19 ›› Issue (4): 376-379.doi: 10.19438/j.cjoms.2021.04.018

• Review Articles • Previous Articles     Next Articles

Research progress of inflammatory microenvironment in NF1 related neurofibroma

YOU Yuan-he, WANG Yan-an   

  1. Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology. Shanghai 200011, China
  • Received:2020-11-18 Revised:2021-02-01 Online:2021-07-20 Published:2021-08-05

Abstract: Neurofibroma is one of the characteristic lesions of neurofibromatosis type 1. However, the pathogenesis of neurofibromas is still not completely known. The highly active RAS-GTP signal transduction of Schwann cells with biallelic inactivation can produce a large number of cytokines, which provides a cytokine-rich microenvironment for immune cell recruitment. In normal peripheral nerves, the proportion of immune inflammatory cells is not high. In NF1-related neurofibromas, 30% of the cells are monocytes/macrophages. Mast cells, T cells and dendritic cells (DC) also present. Increased evidences indicate that there is a correlation between inflammation and tumorigenesis. This review summarized the research progress of inflammatory cells in the microenvironment of NF1-related neurofibroma.

Key words: Neurofibromatosis type 1, Neurofibroma, Mast cell, Macrophage, Tumor inflammatory microenvironment

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