China Journal of Oral and Maxillofacial Surgery ›› 2020, Vol. 18 ›› Issue (1): 71-76.doi: 10.19438/j.cjoms.2020.01.015

• Review Articles • Previous Articles     Next Articles

Research advances in the mechanism of malignant progression of oral submucous fibrosis

ZHANG Da-he, ZHOU Shang-hui   

  1. Department of Oromaxillofacial Head and Neck Oncology, College of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology. Shanghai 200011, China
  • Received:2019-04-22 Online:2020-01-20 Published:2020-03-09

Abstract: Oral submucosal fibrosis is one of the precancerous lesions of oral squamous cell carcinoma. The process of its malignant transformation is complex and its malignant mechanism is still unclear. In this paper, the latest research progress on the mechanism of OSF malignant transformation was reviewed, including chewing areca nut and OSF malignant progression, hypoxia and angiogenesis, epithelial mesenchymal transformation and epigenetic regulation.

Key words: Oral submucous fibrosis, Oral mucosal squamous cell carcinoma, Malignant transformation

CLC Number: