Blood biochemical indexes and bone regeneration in 50 children with cleft lip and palate before and after operation

doi:10.19438/j.cjoms.2020.01.011

Abstract

Abstract: PURPOSE: To study the changes of blood biochemical indexes before and after operation in 50 children with cleft lip and palate and the effect of operation on bone regeneration in cleft palate. METHODS: From April 2014 to April 2016, 50 patients with cleft lip and palate were included. All children were treated surgically. The ratio of white blood cells, platelets, plasma albumin and globulin (hereinafter referred to as white blood cell ratio), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were compared, and the difference of the width of the anterior segment, middle segment, posterior segment width, the area of palate, the width of the cleft lip, the width of the alveolar process, the sagittal distance, the horizontal distance, the inclination of the maxillary protrusion and the fissure area were compared with SPSS 19.0 software package. RESULTS: The white blood cells, platelets, plasma albumin and globulin, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly lower than those before operation (P<0.05). The positive rate of regenerated bone bridge after operation was 80.0%. The average length and width of regenerated bone bridge were (12.3±3.6) mm and (12.3±2.3) mm, respectively. The average width of anterior arch, middle arch and posterior arch were (31.6±2.9) mm, (41.2±6.2) mm and (51.6±6.9) mm, respectively, which were significantly smaller than those before surgery (P<0.05). There were significant differences in area of palate, width of cleft palate, sagittal distance of alveolar fissure, horizontal distance, inclination of anterior maxillary process, area of fissure before and after operation (P<0.05). CONCLUSIONS: The changes of blood biochemical indexes are obvious in children with cleft lip and palate after operation. The formation of regenerative bone bridge in upper palate fissure is beneficial to the development of dental arch and maxilla in children with cleft lip and palate.

Key words: Cleft lip and palate, Blood biochemical index, Bone regeneration in palate fissure, Arch width

CLC Number:

R782.2

YAO Zhi-tao, AN Wei, MAIMAITITUXUN·Tuerdi. Blood biochemical indexes and bone regeneration in 50 children with cleft lip and palate before and after operation[J]. China Journal of Oral and Maxillofacial Surgery, 2020, 18(1): 56-59.

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