Abstract: In the 8th edition of AJCC Cancer Staging Manual published in 2017, TNM staging criteria for oral and oropharyngeal cancer has added indexes of invasion depth (DOI), extranodal extension (ENE), human papillomavirus (HPV), and classified oropharyngeal cancer into HPV positive (p16+) and HPV negative (p16-), establishing different TNM staging criteria. The National Comprehensive Cancer Network (NCCN) has proposed the diagnosis and treatment guidelines for HPV-positive (p16+) oropharyngeal cancer in 2018. NCCN Guidelines Version 1.2019 for head and neck cancers have been issued in March 6, 2019, among which oral and oropharyngeal cancer algorithms were partially revised. To meet the needs of clinical work, the changes of the two versions of oral and oropharyngeal cancer guidelines were partially interpreted in this paper.

Key words: AJCC, TNM classification, NCCN, Treatment guideline, Oral cavity cancer, Oropharyngeal cancer