Abstract: PURPOSE： To investigate the pathogenic distribution and drug resistance characteristics of severe oral and maxillofacial infections in ICU, and to provide evidence for clinical rational use of antibiotics. METHODS: Eight-nine patients with severe oral and maxillofacial infections in ICU were chosen from January, 2010 to December, 2016. The strains from each patient were cultured and identified respectively. Each stain was used to test drug susceptibility. RESULTS: One hundred and thirty strains of pathogenic bacteria were isolated from 89 patients , including 66 strains of gram-negative bacteria,accounting for 50.77%; 59 strains of gram-positive bacteria, accounting for 45.38%; 5 strains of fungi,accounting for 3.85%. Drug susceptibility test showed that the Klebsiella pneumoniae and Escherichia coli were susceptible to imipenem, sulbactam and cefoperazone and tazobactam sodium. Prevotella was susceptible to metronidazole imipenem and sulbactam and cefoperazone. Staphylococcus aureus, Viridans Streptococci and Enterococcus were susceptible to linezolid and vancomycin. Most pathogens were resistant to many antibiotics. CONCLUSIONS: Severe oral and maxillofacial infections in ICU were mainly caused by gram-negative bacteria. Most pathogenic bacteria are resistant to many antibiotics, which suggests that more reasonable use of drug should be performed to prevent drug resistance in clinical treatment.

Key words: Oral and maxillofacial region, Space infection, Severe case, Pathogenic microorganism, Drug resistance