China Journal of Oral and Maxillofacial Surgery ›› 2017, Vol. 15 ›› Issue (5): 427-430.doi: 10.19438/j.cjoms.2017.05.010

• Original Articles • Previous Articles     Next Articles

Parathyroid hormone and vitamin D3 changes perioperative period of oral and maxillofacial surgery

WANG Qiu-xu1, WANG Yao2, XIAO Bo-yang1, LIU Wei-xian1.   

  1. 1.Department of Oral and Maxillofacial Surgery, Shengjing Hospital, China Medical University. Shenyang 110004;
    2.Shenyang Agricultural University. Shenyang 110004, Liaoning Province, China
  • Received:2017-01-09 Online:2017-08-30 Published:2017-10-27

Abstract: PURPOSE: To observe the changes of serum parathyroid hormone (PTH), calcium, phosphate, and vitamin D3 (VitD3) and its receptor (VDR) during perioperative period of oral and maxillofacial surgery and the relationship between these changes and gender, age, operation time, and bleeding. METHODS: From July 2013 to February 2014, we recruited 116 hospitalized patients undergoing oral and maxillofacial surgeries in Shengjing Hospital of China Medical University, from whom 2 mL of fasting venous blood were collected on the second day of admission and the first morning after surgery. Patients' serum VitD3 and VDR concentrations were determined by ELISA; concentrations of Ca2+, P3-, and PTH were obtained from clinical data. SAS 9.2 software package was used for independent samples t test and Spearman correlation analysis. RESULTS: PTH value was significantly increased after surgery, and the difference of PTH index between patients with different gender and different diseases were statistically significant. Ca2+, VitD3, and VDR values were significantly decreased postoperatively. The longer the surgery time, the higher the PTH value; the lower the Ca2+ value, the more bleeding, the higher the PTH value, the lower the Ca2+ value and the more significant was the VDR decrease. There was no significant difference in the change of PTH index between different genders. There was no correlation between the change of serum phosphate and surgery time or blood loss. CONCLUSIONS: The changes in PTH, VitD3, and Ca2+ concentrations in patients undergoing oral and maxillofacial surgery were related to gender, disease, length of surgery, and amount of intraoperative blood loss.

Key words: Parathyroid hormone, Ca2+, P3-, Vitamin D3, Oral and maxillofacial surgery

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