牙源性角化囊肿诊疗中国专家共识

doi:10.19438/j.cjoms.2022.03.001

中国口腔颌面外科杂志 ›› 2022, Vol. 20 ›› Issue (3): 209-218.doi: 10.19438/j.cjoms.2022.03.001

牙源性角化囊肿诊疗中国专家共识

刘冰^1#, 何悦^2#, 彭歆³, 孙长伏⁴, 韩正学⁵, 吴煜农⁶, 彭利伟⁷, 赵熠⁸, 陶谦⁹, 韩新光¹⁰, 李劲松¹¹, 苏彤¹², 李波¹³, 张雷³, 胡砚平¹⁴, 陈传俊¹⁵, 李一¹⁶, 李铁军^17,*, 赵怡芳^1,*

1.武汉大学口腔医院口腔颌面-头颈肿瘤外科,湖北武汉 430070;
2.上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科,上海 200011;
3.北京大学口腔医学院口腔颌面外科,北京 100081;
4.中国医科大学附属口腔医院口腔颌面-头颈外科,辽宁沈阳 110002;
5.首都医科大学附属北京口腔医院口腔颌面-头颈肿瘤科,北京 100050;
6.南京医科大学附属口腔医院口腔颌面外科,江苏南京 210029;
7.郑州大学河南省人民医院口腔医学中心,河南郑州 450000;
8.武汉大学口腔医院口腔修复科,湖北武汉 430070;
9.中山大学光华口腔医学院附属口腔医院口腔颌面外科,广东广州 510055;
10.郑州大学附属第一医院口腔颌面外科,河南郑州 450052;
11.中山大学孙逸仙纪念医院口腔颌面外科,广东广州510120;
12.中南大学湘雅医院口腔颌面外科,湖南长沙 410008;
13.武汉大学口腔医院放射科,湖北武汉 430070;
14.厦门医学院附属口腔医院口腔颌面外科,福建厦门 361006;
15.中国科学技术大学附属第一医院口腔颌面外科,安徽合肥 230001;
16.四川大学华西口腔医院头颈肿瘤外科,四川成都 610041;
17.北京大学口腔医学院口腔病理科,北京 100081

收稿日期:2022-03-14 修回日期:2022-03-26 出版日期:2022-05-20 发布日期:2022-05-20
通讯作者: 李铁军,E-mail: litiejun22@vip.sina.com;赵怡芳,E-mail: yifang@whu.edu.cn。^*共同通信作者
作者简介:刘冰（1968-）,男,博士,主任医师,E-mail: liubing9909@whu.edu.cn;何悦（1973-）,男,博士,教授、主任医师,E-mail: william5218@126.com。^#并列第一作者

Chinese Expert consensus on the diagnosis, treatment of odontogenic keratocyst

LIU Bing¹, HE Yue², PENG Xin³, SUN Chang-fu⁴, HAN Zheng-xue⁵, WU Yu-nong⁶, PENG Li-wei⁷, ZHAO Yi⁸, TAO Qian⁹, HAN Xin-guang¹⁰, LI Jin-song¹¹, SU Tong¹², LI Bo¹³, ZHANG Lei³, HU Yan-ping¹⁴, CHEN Chuan-jun¹⁵, LI Yi¹⁶, LI Tie-jun¹⁷, ZHAO Yi-fang¹

1. Department of Oromaxillofacial Head and Neck Oncology, Hospital of Stomatology, Wuhan University. Wuhan 430070, Hubei Province;
2. Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;
3. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology. Beijing 100081;
4. Department of Oromaxillofacial Head and Neck Surgery, School and Hospital of Stomatology, China Medical University. Shenyang 110002, Liaoning Province;
5. Department of Oral and Maxillofacial Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University. Beijing 100050;
6. Department of Oral and Maxillofacial Surgery, Stomatological Hospital Affiliated to Nanjing Medical University. Nanjing 210029, Jiangsu Province;
7. Department of Stomatology, Henan Provincial Hospital. Zhengzhou 450000, Henan Province;
8. Department of Prosthodontics, Hospital of Stomatology, Wuhan University. Wuhan 430070, Hubei Province;
9. Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University. Guangzhou 510055, Guangdong Province;
10. Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University. Zhengzhou 450052, Henan Province;
11. Department of Oral and Maxillofacial Surgery, Sun Yai-sen Memorial Hospital, Sun Yat-sen University. Guangzhou 510120, Guangdong Province;
12. Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University. Changsha 410008, Hunan Province;
13. Department of Radiology, School and Hospital of Stomatology, Wuhan University. Wuhan 430070, Hubei Province;
14. Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Xiamen Medical College. Xiamen 361006, Fujian Province;
15. Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of University of Science and Technology of China. Hefei 230001, Anhui Province;
16. Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University. Chengdu 610041, Sichuan Province;
17. Department of Oral Pathology, Peking University School of Stomatology. Beijing 100081, China

Received:2022-03-14 Revised:2022-03-26 Online:2022-05-20 Published:2022-05-20

摘要/Abstract

摘要： 牙源性角化囊肿（odontogenic keratocyst, OKC）是常见的良性颌骨囊性病损, 其局部侵袭性生长行为及显著的术后复发倾向,不同于常见的其他类型的颌骨囊肿,而该疾病的命名、分类、疾病性质以及治疗方法选择仍存在争议。随着 OKC 的相关研究深入、治疗理念和外科技术的发展,使降低术后复发率、同时合理保存和重建患者口腔结构和功能这一治疗目标成为可能。为提高OKC的临床诊疗水平,需要对其诊断、治疗、随访等方面进行必要的统一和规范。本专家共识汇集国内相关领域的多学科专家建议和临床实践经验,借鉴国内外相关研究成果,对 OKC 的病理机制、临床表现、影像学特征、组织病理学特点、治疗方法、治疗策略和随访等进行总结概括,以供临床医师参考。

关键词: 牙源性角化囊肿, 诊断, 治疗, 策略, 专家共识

Abstract: Odontogenic keratocyst (OKC) is a common cystic lesion of the jaw. The nomenclature and nature of OKC remain controversial as a result of its local invasive behavior and high tendency of recurrence, which is evidently different from other types of jaw cysts. With the in-depth study of OKC pathogenesis and the advance of treatment concept and surgical techniques, it becomes possible to reduce the rate of postoperative recurrence and simultaneous functional reconstruction of the jaw. To establish standard diagnosis and treatment algorithms or guidelines of OKC, we organized peer experts in China to reach a consensus on pathogenesis, clinical manifestations, imaging characteristics, histopathological features, surgery and postoperative follow-up strategies of OKC for the references of clinicians.

Key words: Odontogenic keratocyst, Diagnosis, Surgery, Strategy, Expert consensus

中图分类号:

R782.2

刘冰, 何悦, 彭歆, 孙长伏, 韩正学, 吴煜农, 彭利伟, 赵熠, 陶谦, 韩新光, 李劲松, 苏彤, 李波, 张雷, 胡砚平, 陈传俊, 李一, 李铁军, 赵怡芳. 牙源性角化囊肿诊疗中国专家共识[J]. 中国口腔颌面外科杂志, 2022, 20(3): 209-218.

LIU Bing, HE Yue, PENG Xin, SUN Chang-fu, HAN Zheng-xue, WU Yu-nong, PENG Li-wei, ZHAO Yi, TAO Qian, HAN Xin-guang, LI Jin-song, SU Tong, LI Bo, ZHANG Lei, HU Yan-ping, CHEN Chuan-jun, LI Yi, LI Tie-jun, ZHAO Yi-fang. Chinese Expert consensus on the diagnosis, treatment of odontogenic keratocyst[J]. China J Oral Maxillofac Surg, 2022, 20(3): 209-218.

参考文献

[1] Shear M.The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? part 1. Clinical and early experimental evidence of aggressive behavior[J]. Oral Oncol, 2002, 38(3): 219-226.
[2] Speight PM, Takata T.New tumour entities in the 4th edition of the World Health Organization Classification of head and neck tumours: odontogenic and maxillofacial bone tumours[J]. Virchows Arch, 2017, 472(3): 331-339.
[3] Li TJ.The odontogenic keratocyst: a cyst, or a cystic neoplasm?[J]. J Dent Res, 2011, 90(2): 133-142.
[4] Shear M.Odontogenic keratocysts: clinical features[J]. Oral Maxillofacial Surg Clin North Am, 2003,15(3): 335-345.
[5] Slusarenko da Silva Y, Stoelinga PJW, Naclério-Homem MDG. Recurrence of nonsyndromic odontogenic keratocyst after marsupialization and delayed enucleation vs. enucleation alone: a systematic review and meta-analysis[J]. Oral Maxillofac Surg, 2019, 23(1): 1-11.
[6] Mohanty S, Dabas J, Verma A, et al.Surgical management of the odontogenic keratocyst: a 20-year experience[J]. Int J Oral Maxillofac Surg, 2021, 50(9): 1168-1176.
[7] Shear M, Speight P.Cysts of the oral and maxillofacial regions[M]. 4th Ed. Oxford: Wiley-Blackwell, 2007: 6-58.
[8] Menon S.Keratocystic odontogenic tumours: etiology, pathogenesis and treatment revisited[J]. J Maxillofac Oral Surg, 2015, 14(3): 541-547.
[9] Heikinheimo K, Kurppa KJ, Laiho A, et al.Early dental epithelial transcription factors distinguish ameloblastoma from keratocystic odontogenic tumor[J]. J Dent Res, 2015, 94(1): 101-111.
[10] Gonçalves DM, Cavalieri GC, Ferreira S, et al.Oncogenic signalling pathways in benign odontogenic cysts and tumours[J]. Oral Oncol, 2017, 72: 165-173.
[11] Sun LS, Li XF, Li TJ.PTCH1 and SMO gene alterations in keratocystic odontogenic tumors[J]. J Dent Res, 2008, 87(6): 575-579.
[12] Qu J, Yu F, Hong Y, et al.Underestimated PTCH1 mutation rate in sporadic keratocystic odontogenic tumors[J]. Oral Oncol, 2015, 51(1): 40-45.
[13] Ally MS, Tang JY, Joseph T, et al.The use of vismodegib to shrink keratocystic odontogenic tumors in patients with basal cell nevus syndrome[J]. JAMA Dermatol, 2014, 150(5): 542-545.
[14] Agaram NP, Collins BM, Barnes L, et al.Molecular analysis to demonstrate that odontogenic keratocysts are neoplastic[J]. Arch Pathol Lab Med, 2004, 128(3): 313-317.
[15] Malcic A, Jukic S, Anic I, et al.Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst[J]. J Oral Pathol Med, 2008, 37(5): 294-301.
[16] Man QW, Li RF, Li SR, et al.Single-cell RNA sequencing reveals CXCLs enriched fibroblasts within odontogenic keratocysts[J]. J Inflamm Res, 2021, 14: 7359-7369.
[17] 王彦瑾, 谢晓艳, 洪瑛瑛, 等. 844例牙源性角化囊肿的临床病理学分析[J]. 北京大学学报(医学版), 2020, 52(1): 1-18.
Wang YJ, Xie XY, Hong YY, et al.Clinicopathological analysis of 844 cases of odontogenic keratocysts[J]. Journal of Peking University (Medical Science),2020, 52(1): 1-18.
[18] 范永晶, 金武龙, 刘莹. 200例颌骨囊性病变临床回顾分析[J].中国口腔颌面外科杂志, 2019, 17(3): 269-274.
Fan YJ, Jin WL, Liu Y.Clinical retrospective analysis of 200 cases with cystic lesions of the jaw bone[J]. China Journal of Oral and Maxillofacial Surgery, 2019, 17(3): 269-274.
[19] 彭利伟, 赵怡芳, 张文峰, 等. 669例牙源性颌骨囊肿临床分析[J]. 临床口腔医学杂志, 2004, 20(5): 297-299.
Peng WL, Zhao YF, Zhang WF, et al.The odontogenic jaw cysts :analysis of the clinical parameters of 669 cases[J]. Journal of Clinical Stomatology,2004, 20(5): 297-299.
[20] Gonzalez-Alva P, Tanaka A, Oku Y, et al.Keratocystic odontogenic tumor: a retrospective study of 183 cases[J]. J Oral Sci, 2008, 50(2): 205-212.
[21] Antonoglou GN, Sandor GK, Koidou VP, et al.Non-syndromic and syndromic keratocystic odontogenic tumors: systematic review and meta-analysis of recurrences[J]. J Craniomaxillofac Surg, 2014, 42(7): e364-e371.
[22] Borghesi A, Nardi C, Giannitto C, et al.Odontogenic keratocyst: imaging features of a benign lesion with an aggressive behaviour[J]. Insights Imaging, 2018, 9(5): 883-897.
[23] van Rensburg LJ, Paquette M, Morkel JA, et al. Correlative MRI and CT imaging of the odontogenic keratocyst: a review of twenty-one cases[J]. Oral Maxillofac Surg Clin North Am, 2003, 15(3): 363-382.
[24] Tsukamoto G, Sasaki A, Akiyama T, et al.A radiologic analysis of dentigerous cysts and odontogenic keratocysts associated with a mandibular third molar[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2001, 91(6): 743-747.
[25] Myoung H, Hong SP, Hong SD, et al.Odontogenic keratocyst: review of 256 cases for recurrence and clinicopathologic parameters[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2001, 91(3): 328-333.
[26] Apajalahti S, Hagstrom J, Lindqvist C, et al.Computerized tomography findings and recurrence of keratocystic odontogenic tumor of the mandible and maxillofacial region in a series of 46 patients[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2011, 111(3): e29-e37.
[27] Brauer HU, Diaz C, Manegold BG.Radiographic assessment of a keratocystic odontogenic tumour using cone-beam computed tomography[J]. Eur Arch Paediatr Dent, 2013, 14(3): 173-177.
[28] Langlais RP, van Rensburg LJ, Guidry J, et al. Magnetic resonance imaging in dentistry[J]. Dent Clin North Am, 2000, 44(2): 411-426.
[29] 于世凤. 口腔组织病理学 [M]. 北京: 人民卫生出版社, 2012.
Yu SF.Oral histopathology[M]. Beijing: People's Medical Publishing House, 2012.
[30] Jordan RCK.Histology and ultrastructural features of the odontogenic keratocyst[J]. Oral Maxillofac Surg Clin North Am, 2003, 15(3): 325-333.
[31] 赵怡芳. 牙源性角化囊肿的手术治疗:保守性或根治性方法[J]. 口腔颌面外科杂志, 2008, 18(4): 229-233.
Zhao YF.Surgical management of odontogenic keratocysts: conservative or radical approach?[J]. Journal of Oral and Maxillofacial Surgery, 2008, 18(4): 229-233.
[32] Sharif FN, Oliver R, Sweet C, et al. Interventions for the treatment of keratocystic odontogenic tumours [KCOT, odontogenic keratocysts (OKC)][J]. Cochrane Database Syst Rev, 2010, (9): CD008464.
[33] Al-Moraissi EA, Dahan AA, Alwadeai MS, et al.What surgical treatment has the lowest recurrence rate following the management of keratocystic odontogenic tumor? a large systematic review and meta-analysis[J]. J Craniomaxillofac Surg, 2017, 45(1): 131-144.
[34] Schmidt BL.The use of liquid nitrogen cryotherapy in the management of the odontogenic keratocyst[J]. Oral Maxillofac Surg Clin North Am, 2003, 15(3): 393-405.
[35] Salmassy DA, Pogrel MA.Liquid nitrogen cryosurgery and immediate bone grafting in the management of aggressive primary jaw lesions[J]. J Oral Maxillofac Surg, 1995, 53(7): 784-790.
[36] 陶谦, 何悦, 刘冰, 等. 开窗治疗颌骨囊性病变的专家共识[J].口腔疾病防治, 2020, 28(2): 69-72.
Tao Q, He Y, Liu B, et al.Expert consensus on marsupialization of cystic lesions of the jaw[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(2): 69-72.
[37] Stoelinga PJ.The treatment of odontogenic keratocysts by excision of the overlying, attached mucosa, enucleation, and treatment of the bony defect with carnoy solution[J]. J Oral Maxillofac Surg, 2005, 63(11): 1662-1666.
[38] Zhao YF, Wei JX, Wang SP.Treatment of odontogenic keratocysts: a follow-up of 255 Chinese patients[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2002, 94(2): 151-156.
[39] Wang Y, Chang SH, Lin ZY, et al.Endoscopic-assisted enucleation of large mandibular odontogenic cysts[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2020, 129(2): 115-119.
[40] Gosau M, Draenert FG, Müller S, et al.Two modifications in the treatment of keratocystic odontogenic tumors (KCOT) and the use of Carnoy’s solution (CS)--a retrospective study lasting between 2 and 10 years[J]. Clin Oral Investig, 2010, 14(1): 27-34.
[41] 周景兰, 焦顺利, 陈晓华, 等. 复发性牙源性角化囊肿刮除及冷冻治疗的效果评价[J]. 上海口腔医学, 2005, 14(5): 45-47.
Zhou JL, Jiao SL, Chen XH, et al.Treatment of recurrent odontogenic keratocyst with enucleation and cryosurgery: a retrospective study of 10 cases[J]. Shanghai Journal of Stomatology, 2005, 14(5): 45-47.
[42] Berretta LM, Melo G, Mello FW, et al. Effectiveness of marsupialisation and decompression on the reduction of cystic jaw lesions: a systematic review [J]. Br J Oral Maxillofac Surg, 2021, 23: S0266-4356(21)00109-1.
[43] August M, Faquin WC, Troulis MJ, et al.Dedifferentiation of odontogenic keratocyst epithelium after cyst decompression[J]. J Oral Maxillofac Surg, 2003, 61(6): 678-683.
[44] 刘冰, 赵怡芳, 张文峰, 等. 负压吸引术矫治下颌骨囊性病变所致颌面膨胀畸形[J]. 中华整形外科杂志, 2007, 23(4): 310-312.
Liu B, Zhao YF, Zhang WF, et al.Correction of maxillofacial expansive deformities resulted from cystic lesions of the mandible by suction drainage[J]. Chinese Journal of Plastic Surgery, 2007, 23(4): 310-312.
[45] Moreno-Rodríguez P, Guerrero LM, Gómez-Delgado A, et al.Active decompression and distraction osteogenesis for the treatment of calcifying odontogenic cyst[J]. Oral Maxillofac Surg, 2021, 25(1): 89-97.
[46] 胡永杰, 李思毅, 徐立群, 等. 减压术治疗下颌骨大型牙源性角化囊肿的临床研究[J]. 中国口腔颌面外科杂志, 2005, 3(4): 299-302.
Hu YJ, Li SY, Xu LQ, et al.Clinical study of large mandibular odontogenic keratocyst treated by decompression[J]. China Journal of Oral and Maxillofacial Surgery,2005, 3(4): 299-302.
[47] Kolokythas A, Fernandes RP, Pazoki A, et al.Odontogenic keratocyst: to decompress or not to decompress? a comparative study of decompression and enucleation versus resection/peripheral ostectomy[J]. J Oral Maxillofac Surg, 2007, 65(4): 640-644.
[48] 赵熠, 陈刚, 刘冰, 等. 牙源性角化囊肿袋形术后的骨形成与改建[J]. 口腔医学研究, 2013, 29(11): 1062-1064.
Zhao Y, Chen G, Liu B, et al.Characteristics of the bone formation and remodelling following marsupialization of jaw odontogenic keratocysts[J]. J Oral Sci Res, 2013, 29(11): 1062-1064.
[49] Fidele NB, Zheng YY, Zhao YF, et al.Recurrence of odontogenic keratocysts and possible prognostic factors: review of 455 patients[J]. Med Oral Patol Oral Cir Bucal, 2019, 24(4): e491-e501.
[50] 赵怡芳, 刘冰. 颌骨囊性病受累牙处理的现代策略[J]. 口腔颌面外科杂志, 2019, 29(1): 1-10.
Zhao YF, Liu B.Contemporary strategies for managing tooth/teeth associated with cystic lesions of the jaws[J]. Journal of Oral and Maxillofacial Surgery, 2019, 29(1): 1-10.
[51] Zhao Y, Liu B, Zhao YF.Controversies regarding the management of teeth associated with cystic lesions of the jaws[J]. Chin J Dent Res, 2019, 22(2): 81-92.
[52] 马宏涛, 王海宁, 孙坚. 颌骨大型囊性病变相关牙的保存治疗[J]. 中国口腔颌面外科杂志, 2011, 9(3): 234-236.
Ma HT, Wang HN, Sun J.Conservative treatment of the teeth involved by large cystic lesion in jaws[J]. China Journal of Oral and Maxillofacial Surgery, 2011, 9(3): 234-236.
[53] 廖亚洲, 刘冰, 赵怡芳. 牙源性角化囊性瘤患区牙保存的临床评估[J]. 武汉大学学报(医学版), 2013, 34(3): 411-414.
Liao YZ, Liu B, Zhao YF.Clinical assessment of the preservation of teeth involved in keratocystic odontogenic tumor[J]. Journal of Wuhan University (Medical Science), 2013, 34(3): 411-414.
[54] Crescente BB. Scolari N, Meirelles LS, et al.A multimodal protocol treatment to odontogenic keratocyst[J]. Int J Oral Maxillofac Surg, 2019, 48: 225-226.
[55] Fidele NB, Zhao YF, Wu TF, et al.Treatment of multiple odontogenic keratocysts involving Chinese patients[J]. J Oral Maxillofac Surg, 2019, 77(10): 2044-2054.
[56] Finkelstein MW, Hellstein JW, Lake KS, et al.Keratocystic odontogenic tumor: a retrospective analysis of genetic, immunohistochemical and therapeutic features. Proposal of a multicenter clinical survey tool[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2013, 116(1): 75-83.

牙源性角化囊肿诊疗中国专家共识

Chinese Expert consensus on the diagnosis, treatment of odontogenic keratocyst

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